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Blood pressure screening in midlife aids in prediction of dementia later in life

Moberg, Lena (author)
Uppsala universitet,Institutionen för medicinska vetenskaper
Leppert, Jerzy (author)
Uppsala universitet,Centrum för klinisk forskning, Västerås,Institutionen för folkhälso- och vårdvetenskap
Liljeström, Simon (author)
Uppsala universitet,Centrum för klinisk forskning, Västerås
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Rehn, Mattias (author)
Uppsala universitet,Centrum för klinisk forskning, Västerås
Kilander, Lena (author)
Uppsala universitet,Geriatrik
Chabok, Abbas, 1964- (author)
Uppsala universitet,Centrum för klinisk forskning, Västerås
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 (creator_code:org_t)
2022-01-03
2022
English.
In: Upsala Journal of Medical Sciences. - : UPSALA MED SOC. - 0300-9734 .- 2000-1967. ; 127:1
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Background: There is substantial evidence that midlife hypertension is a risk factor for late life dementia. Our aim was to investigate if even high blood pressure at a single timepoint in midlife can predict an increased risk for all-cause dementia, Alzheimer's disease (AD), or vascular dementia (VaD) later in life. Methods: The community-based study population comprised 30,102 dementia-free individuals from the Westmannia Cardiovascular Risk Factors Study. The participants were aged 40 or 50 years when the health examination took place in 1990-2000. Diagnose registers from both hospitals and primary healthcare centers were used to identify individuals who after inclusion to the study developed dementia.The association between midlife high blood pressure (defined as systolic blood pressure >140 and/or diastolic blood pressure >90 mmHg) at a single timepoint and dementia was adjusted for age, gender, body mass index (BMI), fasting blood glucose, education, smoking, and physical activity level. Multivariate binary cox regression analyses were used. Results: After a mean follow-up time of 24 years resulting in 662,244 person/years, 761 (2.5%) individuals had been diagnosed with dementia. Midlife high blood pressure at a single timepoint predicted allcause dementia (hazard ratio [HR]: 1.22, 95% confidence interval [CI]: 1.02-1.45) and VaD (HR: 2.10, 95% CI: 1.47-3.00) but not AD (HR: 1.06, 95% CI: 0.81-1.38). Conclusion: This study suggests that even midlife high blood pressure at a single timepoint predicts allcause dementia and more than doubles the risk for VaD later in life independently of established confounders. Even though there was no such association with AD, this strengthens the importance of midlife health examinations in order to identify individuals with hypertension and initiate treatment.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)

Keyword

Midlife hypertension
screening
dementia
prediction
long-term follow-up
prevalence

Publication and Content Type

ref (subject category)
art (subject category)

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