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Progress Identifyin...
Progress Identifying and Analyzing the Human Proteome : 2021 Metrics from the HUPO Human Proteome Project
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- Omenn, Gilbert S. (författare)
- Inst Syst Biol, Seattle, WA 98109 USA.
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- Lane, Lydie (författare)
- SIB Swiss Inst Bioinformat, CALIPHO Grp, CH-1015 Lausanne, Switzerland.
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- Overall, Christopher M. (författare)
- Univ British Columbia, Vancouver, BC V6T 1Z4, Canada.
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- Paik, Young-Ki (författare)
- Yonsei Proteome Res Ctr, Seoul 03722, South Korea.;Yonsei Univ, Seoul 03722, South Korea.
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- Cristea, Ileana M. (författare)
- Princeton Univ, Princeton, NJ 08544 USA.
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- Corrales, Fernando J. (författare)
- Ctr Nacl Biotecnol, Madrid 28049, Spain.
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- Lindskog, Cecilia (författare)
- Uppsala universitet,Klinisk och experimentell patologi
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- Weintraub, Susan (författare)
- Univ Texas Hlth San Antonio, San Antonio, TX 78229 USA.
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- Roehrl, Michael H. A. (författare)
- Mem Sloan Kettering Canc Ctr, New York, NY 10065 USA.
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- Liu, Siqi (författare)
- BGI Grp, Shenzhen 518083, Peoples R China.
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- Bandeira, Nuno (författare)
- Univ Calif San Diego, La Jolla, CA 92093 USA.
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- Srivastava, Sudhir (författare)
- NCI, Rockville, MD 20850 USA.
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- Chen, Yu-Ju (författare)
- Natl Taiwan Univ, Acad Sinica, Taipei 11529, Taiwan.
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- Aebersold, Ruedi (författare)
- Swiss Fed Inst Technol, CH-8092 Zurich, Switzerland.;Univ Zurich, CH-8092 Zurich, Switzerland.
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- Moritz, Robert L. (författare)
- Inst Syst Biol, Seattle, WA 98109 USA.
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- Deutsch, Eric W. (författare)
- Inst Syst Biol, Seattle, WA 98109 USA.
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Inst Syst Biol, Seattle, WA 98109 USA SIB Swiss Inst Bioinformat, CALIPHO Grp, CH-1015 Lausanne, Switzerland. (creator_code:org_t)
- 2021-10-20
- 2021
- Engelska.
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Ingår i: Journal of Proteome Research. - : American Chemical Society (ACS). - 1535-3893 .- 1535-3907. ; 20:12, s. 5227-5240
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The 2021 Metrics of the HUPO Human Proteome Project (HPP) show that protein expression has now been credibly detected (neXtProt PE1 level) for 18 357 (92.8%) of the 19 778 predicted proteins coded in the human genome, a gain of 483 since 2020 from reports throughout the world reanalyzed by the HPP. Conversely, the number of neXtProt PE2, PE3, and PE4 missing proteins has been reduced by 478 to 1421. This represents remarkable progress on the proteome parts list. The utilization of proteomics in a broad array of biological and clinical studies likewise continues to expand with many important findings and effective integration with other omics platforms. We present highlights from the Immunopeptidomics, Glycoproteomics, Infectious Disease, Cardiovascular, MusculoSkeletal, Liver, and Cancers B/D-HPP teams and from the Knowledge-base, Mass Spectrometry, Antibody Profiling, and Pathology resource pillars, as well as ethical considerations important to the clinical utilization of proteomics and protein biomarkers.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Nyckelord
- Human Proteome Project (HPP)
- neXtProt protein existence (PE) metrics
- missing proteins (MP)
- non-MS PE1 proteins
- uncharacterized protein existence 1 (uPE1)
- Chromosome-centric HPP (C-HPP)
- Biology and Disease-HPP (B/D-HPP)
- PeptideAtlas
- Mass Spectrometry Interactive Virtual Environment (MassIVE)
- Human Protein Atlas
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Omenn, Gilbert S ...
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Lane, Lydie
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Overall, Christo ...
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Paik, Young-Ki
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Cristea, Ileana ...
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Corrales, Fernan ...
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Lindskog, Cecili ...
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Weintraub, Susan
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Roehrl, Michael ...
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Liu, Siqi
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Bandeira, Nuno
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Srivastava, Sudh ...
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Chen, Yu-Ju
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Aebersold, Ruedi
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Moritz, Robert L ...
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Deutsch, Eric W.
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