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Prospective epidemiological, molecular, and genetic characterization of a novel coronavirus disease in the Val Venosta/Vinschgau : the CHRIS COVID-19 study protocol

Pattaro, Cristian (author)
Institute for Biomedicine (affiliated with the University of Lübeck), Eurac Research, Bolzano, Italy
Barbieri, Giulia (author)
Institute for Biomedicine (affiliated with the University of Lübeck), Eurac Research, Bolzano, Italy
Foco, Luisa (author)
Institute for Biomedicine (affiliated with the University of Lübeck), Eurac Research, Bolzano, Italy
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Weichenberger, Christian X. (author)
Institute for Biomedicine (affiliated with the University of Lübeck), Eurac Research, Bolzano, Italy
Biasiotto, Roberta (author)
Institute for Biomedicine (affiliated with the University of Lübeck), Eurac Research, Bolzano, Italy
De Grandi, Alessandro (author)
Institute for Biomedicine (affiliated with the University of Lübeck), Eurac Research, Bolzano, Italy
Fuchsberger, Christian (author)
Institute for Biomedicine (affiliated with the University of Lübeck), Eurac Research, Bolzano, Italy
Egger, Clemens (author)
Institute for Biomedicine (affiliated with the University of Lübeck), Eurac Research, Bolzano, Italy
Amon, Vera S. C. (author)
Institute for Biomedicine (affiliated with the University of Lübeck), Eurac Research, Bolzano, Italy
Hicks, Andrew A. (author)
Institute for Biomedicine (affiliated with the University of Lübeck), Eurac Research, Bolzano, Italy
Mian, Michael (author)
Department of Haematology, Hospital of Bolzano SABES-ASDAA, Bolzano, Italy;College of Health-Care Professions, Claudiana, Bolzano, Italy
Mahlknecht, Angelika (author)
Institute of General Medicine, Provincial School of Health (Claudiana), Bolzano, Italy;Institute of General Practice, Family Medicine and Preventive Medicine, Paracelsus Medical University, Salzburg, Austria
Lombardo, Stefano (author)
Provincial Institute of Statistics (ASTAT), Administration of the Autonomous Province of Bolzano, Italy
Meier, Horand (author)
Clinical Governance Unit, Administration of the Autonomous Province of Bolzano, Italy
Weiss, Helmuth (author)
Hospital of Silandro, Healthcare System of the Autonomous Province of Bolzano, Italy
Rainer, Robert (author)
Hospital of Silandro, Healthcare System of the Autonomous Province of Bolzano, Italy
Dejaco, Christian (author)
Department of Rheumatology, Medical University Graz, Austria;Department of Rheumatology, Hospital of Bruneck (SABES-ASDAA), Italy
Weiss, Günter (author)
Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria
Lavezzo, Enrico (author)
Department of Molecular Medicine, University of Padova, Italy
Crisanti, Andrea (author)
Department of Molecular Medicine, University of Padova, Italy
Pizzato, Massimo (author)
Laboratory of Virus-Cell Interaction, Centre for Integrative Biology, University of Trento, Italy
Domingues, Francisco S. (author)
Institute for Biomedicine (affiliated with the University of Lübeck), Eurac Research, Bolzano, Italy
Mascalzoni, Deborah, 1973- (author)
Uppsala universitet,Centrum för forsknings- och bioetik,Institute for Biomedicine (affiliated with the University of Lübeck), Eurac Research, Bolzano, Italy
Gögele, Martin (author)
Institute for Biomedicine (affiliated with the University of Lübeck), Eurac Research, Bolzano, Italy
Melotti, Roberto (author)
Institute for Biomedicine (affiliated with the University of Lübeck), Eurac Research, Bolzano, Italy
Pramstaller, Peter P. (author)
Institute for Biomedicine (affiliated with the University of Lübeck), Eurac Research, Bolzano, Italy
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 (creator_code:org_t)
2021-10-12
2022
English.
In: Pathogens and Global Health. - : Taylor & Francis. - 2047-7724 .- 2047-7732. ; 116:2, s. 128-136
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • The COVID-19 pandemic has been threatening the healthcare and socioeconomic systems of entire nations. While population-based surveys to assess the distribution of SARS-CoV-2 infection have become a priority, pre-existing longitudinal studies are ideally suited to assess the determinants of COVID-19 onset and severity.The Cooperative Health Research In South Tyrol (CHRIS) study completed the baseline recruitment of 13,393 adults from the Venosta/Vinschgau rural district in 2018, collecting extensive phenotypic and biomarker data, metabolomic data, densely imputed genotype and whole-exome sequencing data.Based on CHRIS, we designed a prospective study, called CHRIS COVID-19, aimed at: 1) estimating the incidence of SARS-CoV-2 infections; 2) screening for and investigating the determinants of incident infection among CHRIS participants and their household members; 3) monitoring the immune response of infected participants prospectively.An online screening questionnaire was sent to all CHRIS participants and their household members. A random sample of 1450 participants representative of the district population was invited to assess active (nasopharyngeal swab) or past (serum antibody test) infections. We prospectively invited for complete SARS-CoV-2 testing all questionnaire completers gauged as possible cases of past infection and their household members. In positive tested individuals, antibody response is monitored quarterly for one year. Untested and negative participants receive the screening questionnaire every four weeks until gauged as possible incident cases or till the study end.Originated from a collaboration between researchers and community stakeholders, the CHRIS COVID-19 study aims at generating knowledge about the epidemiological, molecular, and genetic characterization of COVID-19 and its long-term sequelae.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Infectious Medicine (hsv//eng)

Keyword

COVID-19
SARS-CoV-2
Cooperative Health Research In South Tyrol (CHRIS) study
general population
novel coronavirus

Publication and Content Type

ref (subject category)
art (subject category)

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