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Long-term tolerabil...
Long-term tolerability and efficacy after initial PegIFN-α addition to dasatinib in CML-CP : Five-year follow-up of the NordCML007 study
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- Flygt, Hjalmar (author)
- Uppsala universitet,Hematologi
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- Söderlund, Stina (author)
- Uppsala universitet,Hematologi
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- Stentoft, Jesper (author)
- Aarhus Univ Hosp, Dept Hematol, Aarhus, Denmark.
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- Richter, Johan (author)
- Skane Univ Hosp, Dept Hematol Oncol & Radiat Phys, Lund, Sweden.
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- Koskenvesa, Perttu (author)
- Univ Helsinki, Helsinki Univ Hosp, Comprehens Canc Ctr, Hematol Res Unit Helsinki, Helsinki, Finland.;Univ Helsinki, Helsinki Univ Hosp, Comprehens Canc Ctr, Dept Hematol, Helsinki, Finland.
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- Mustjoki, Satu (author)
- Univ Helsinki, Helsinki Univ Hosp, Comprehens Canc Ctr, Hematol Res Unit Helsinki, Helsinki, Finland.;Univ Helsinki, Helsinki Univ Hosp, Comprehens Canc Ctr, Dept Hematol, Helsinki, Finland.;Univ Helsinki, Translat Immunol Res Program, Helsinki, Finland.;Univ Helsinki, Dept Clin Chem & Hematol, Helsinki, Finland.
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- Majeed, Waleed (author)
- Stavanger Univ Hosp, Dept Hematooncol, Stavanger, Norway.
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- Lübking, Anna (author)
- Skane Univ Hosp, Dept Hematol Oncol & Radiat Phys, Lund, Sweden.
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- Dreimane, Arta (author)
- Linköping Univ Hosp, Dept Hematol, Linköping, Sweden.
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- Markevärn, Berit (author)
- Umeå Univ Hosp, Dept Hematol, Umeå, Sweden.
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- Stenke, Leif (author)
- Karolinska Institutet
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- Myhr Eriksson, Kristina (author)
- Sunderby Hosp, Dept Internal Med & Hematol, Luleå, Sweden.
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- Gjertsen, Bjørn Tore (author)
- Haukeland Hosp, Hematol Sect, Dept Internal Med, Bergen, Norway.
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- Gedde-Dahl, Tobias (author)
- Natl Hosp Norway, Oslo Univ Hosp, Dept Hematol, Oslo, Norway.
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- Dimitrijevic, Andreja (author)
- Odense Univ Hosp, Dept Hematol, Odense, Denmark.
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- Udby, Lene (author)
- Zealand Univ Hosp, Dept Hematol, Roskilde, Denmark.
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- Olsson-Strömberg, Ulla (author)
- Uppsala universitet,Hematologi
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- Hjorth-Hansen, Henrik (author)
- St Olavs Hosp Trondheim, Dept Hematol, Trondheim, Norway.;Norwegian Univ Sci & Technol, Dept Clin & Mol Med, Trondheim, Norway.
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(creator_code:org_t)
- 2021-08-31
- 2021
- English.
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In: European Journal of Haematology. - : John Wiley & Sons. - 0902-4441 .- 1600-0609. ; 107:6, s. 617-623
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Abstract
Subject headings
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- ObjectivesTreatment-free remission (TFR) has emerged as a treatment goal in chronic myeloid leukemia in the chronic phase (CML-CP). Attempts to increase proportion of patients achieving TFR include combination of tyrosine kinase inhibitors (TKI) and other drugs. Interferon-α in addition to TKI has shown promising efficacy but with dose-dependent toxicity and discontinuations. NordCML007 was initiated to study the efficacy and safety of low dose pegylated IFN-α (PegIFN-α) in combination with dasatinib (DAS) in CML-CP.MethodsForty patients with newly diagnosed CML-CP were given DAS upfront. After month 3 (M3) 15 μg/wk of PegIFN-α was added and increased to 25 μg/wk from M7 until M15. DAS treatment was continued and adverse events and BCR-ABL1 qRT-PCR values were reported yearly after M24. Results from M1 to M18 have previously been published, and here we present long-term data.ResultsAfter 5 years of follow-up, there were no suspected unexpected serious adverse reactions, no increase in serosal effusions, no disease progressions and no CML-related deaths. Rates of MR3.0 (MMR), MR4.0 and MR4.5 were 84.6%, 64.1% and 51.3% respectively at M60, and 95% of patients reached MMR at some point during the study.ConclusionInitial addition of PegIFN-α to DAS shows good long-term efficacy without increased toxicity.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- BCR-ABL Positive
- chronic myelogenous leukemia
- clinical trial
- dasatinib
- interferon-alpha
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Flygt, Hjalmar
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Söderlund, Stina
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Stentoft, Jesper
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Richter, Johan
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Koskenvesa, Pert ...
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Mustjoki, Satu
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Majeed, Waleed
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Lübking, Anna
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Dreimane, Arta
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Markevärn, Berit
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Stenke, Leif
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Myhr Eriksson, K ...
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Gjertsen, Bjørn ...
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Gedde-Dahl, Tobi ...
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Dimitrijevic, An ...
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Udby, Lene
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Olsson-Strömberg ...
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Hjorth-Hansen, H ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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European Journal ...
- By the university
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Uppsala University
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Karolinska Institutet