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Network pharmacolog...
Network pharmacological mechanism of Cinobufotalin against glioma
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- Li, Cong (författare)
- Guangzhou Univ Chinese Med, Affiliated Hosp 2, Guangdong Prov Hosp Chinese Med, Guangzhou, Peoples R China.
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- Guo, Hanyu (författare)
- Guangzhou Univ Chinese Med, Affiliated Hosp 2, Guangdong Prov Hosp Chinese Med, Guangzhou, Peoples R China.
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- Wang, Chao (författare)
- Guangzhou Univ Chinese Med, Affiliated Hosp 2, Guangdong Prov Hosp Chinese Med, Guangzhou, Peoples R China.
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- Zhan, Wengang (författare)
- Guangzhou Univ Chinese Med, Affiliated Hosp 2, Guangdong Prov Hosp Chinese Med, Guangzhou, Peoples R China.
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- Tan, Qijia (författare)
- Guangzhou Univ Chinese Med, Affiliated Hosp 2, Guangdong Prov Hosp Chinese Med, Guangzhou, Peoples R China.
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- Xie, Caijun (författare)
- Guangzhou Univ Chinese Med, Affiliated Hosp 2, Guangdong Prov Hosp Chinese Med, Guangzhou, Peoples R China.
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- Sharma, Aruna (författare)
- Uppsala universitet,Anestesiologi och intensivvård
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- Sharma, Hari Shanker (författare)
- Uppsala universitet,Anestesiologi och intensivvård,Institutionen för medicinsk cellbiologi
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- Chen, Lin (författare)
- Beijing Univ Tradit Chinese Med, Dongzhimen Hosp, Dept Neurosurg, Beijing, Peoples R China.
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- Zhang, Zhiqiang (författare)
- Guangzhou Univ Chinese Med, Affiliated Hosp 2, Guangdong Prov Hosp Chinese Med, Guangzhou, Peoples R China.
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Guangzhou Univ Chinese Med, Affiliated Hosp 2, Guangdong Prov Hosp Chinese Med, Guangzhou, Peoples R China Anestesiologi och intensivvård (creator_code:org_t)
- ELSEVIER ACADEMIC PRESS INC, 2021
- 2021
- Engelska.
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Ingår i: NANOMEDICINE AND NEUROPROTECTION IN BRAIN DISEASES. - : ELSEVIER ACADEMIC PRESS INC. - 9780323901628 ; , s. 119-137
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objective: Cinobufotalin was extracted from the skin of Chinese giant salamander or black sable with good clinical effect against tumor. This study aims to explore the mechanism of Cinobufotalin components and predict the target of action of Cinobufotalin on glioma. Methods: The active components of Cinobufotalin were screened by the Chinese medicine pharmacology database and analysis platform (TCMSP), PubChem database, etc. The potential molecular components and targets were identified and enrichment analysis was conducted through the construction of related networks and analysis of their characteristics. Relevant targets of glioma were searched through TTD, DRUGBANK, and other databases, and the intersection was found and the key targets were found too. Results: A total of 21 active components and 184 target genes of Cinobufotalin were found. According to the enrichment analysis results, the pharmacological mechanism of Cinobufotalin mainly includes inhibition of the cell cycle, promotion of cell apoptosis, and regulation of immunity. On this basis, RAC1, FOS, and NOS3 can be preliminarily predicted as potential targets of Cinobufotalin in the treatment of glioma. Conclusions: The screening of active ingredients and target prediction based on network pharmacology can provide a new research idea for the multi-target treatment of glioma with Cinobufotalin.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Network pharmacology
- Cinobufotalin
- Glioma
- Target prediction
Publikations- och innehållstyp
- ref (ämneskategori)
- kap (ämneskategori)
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Li, Cong
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Guo, Hanyu
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Wang, Chao
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Zhan, Wengang
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Tan, Qijia
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Xie, Caijun
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visa fler...
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Sharma, Aruna
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Sharma, Hari Sha ...
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Chen, Lin
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Zhang, Zhiqiang
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Uppsala universitet