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Postnatal exposure ...
Postnatal exposure to fluoxetine led to cognitive-emotional alterations and decreased parvalbumin positive neurons in the hippocampus of juvenile Wistar rats
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- Rodrigues Meurer, Ywlliane da Silva (author)
- Univ Fed Sao Paulo, Dept Pharmacol, Behav Neurosci Lab, Sao Paulo, Brazil.;Univ Fed Paraiba, Memory & Cognit Studies Lab, Postgrad Program Cognit Neurosci & Behav, Dept Psychol, Joao Pessoa, Paraiba, Brazil.;Univ Fed Rio Grande do Norte, Dept Physiol & Behav, Lab Neurochem Studies, Natal, RN, Brazil.
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- Guedes Linhares, Sara Sophia (author)
- Univ Fed Rio Grande do Norte, Dept Physiol & Behav, Lab Neurochem Studies, Natal, RN, Brazil.
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- Lima, Alvaro da Costa (author)
- Univ Fed Paraiba, Memory & Cognit Studies Lab, Postgrad Program Cognit Neurosci & Behav, Dept Psychol, Joao Pessoa, Paraiba, Brazil.
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- Queiroz Aquino, Antonio Carlos (author)
- Univ Fed Rio Grande do Norte, Dept Physiol & Behav, Lab Neurochem Studies, Natal, RN, Brazil.
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- Brandao, Luiz Eduardo M. (author)
- Uppsala universitet,Hematologi,Transplantation och regenerativ medicin
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- Noga, Diana Aline (author)
- Uppsala universitet,Institutionen för neurovetenskap,Uppsala Univ, Dept Neurosci, Uppsala, Sweden.
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- das Chagas Campelo, Clarissa Loureiro (author)
- Univ Fed Rio Grande do Norte, Dept Physiol & Behav, Lab Neurochem Studies, Natal, RN, Brazil.
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- Lima, Ramon Hypolito (author)
- Santos Dumont Inst, Grad Program Neuroengn, Edmond & Lily Safra Int Inst Neurosci, Macaiba, Brazil.
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- Cavalcante, Jeferson de Souza (author)
- Univ Fed Rio Grande do Norte, Dept Physiol & Behav, Lab Neurochem Studies, Natal, RN, Brazil.
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- Galvao Januario Engelberth, Rovena Clara (author)
- Univ Fed Rio Grande do Norte, Dept Physiol & Behav, Lab Neurochem Studies, Natal, RN, Brazil.
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- Ribeiro, Alessandra Mussi (author)
- Univ Fed Sao Paulo, Lab Neurosci & Bioprospecting Nat Prod, Dept Biosci, Santos, SP, Brazil.
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- Silva, Regina Helena (author)
- Univ Fed Sao Paulo, Dept Pharmacol, Behav Neurosci Lab, Sao Paulo, Brazil.
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Univ Fed Sao Paulo, Dept Pharmacol, Behav Neurosci Lab, Sao Paulo, Brazil;Univ Fed Paraiba, Memory & Cognit Studies Lab, Postgrad Program Cognit Neurosci & Behav, Dept Psychol, Joao Pessoa, Paraiba, Brazil.;Univ Fed Rio Grande do Norte, Dept Physiol & Behav, Lab Neurochem Studies, Natal, RN, Brazil. Univ Fed Rio Grande do Norte, Dept Physiol & Behav, Lab Neurochem Studies, Natal, RN, Brazil. (creator_code:org_t)
- 2021-07-17
- 2021
- English.
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In: International Journal of Developmental Neuroscience. - : John Wiley & Sons. - 0736-5748 .- 1873-474X. ; 81:7, s. 616-632
- Related links:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- The exposure to selective serotonin reuptake inhibitors (SSRIs) during development results in behavioural impairment in adulthood in humans and animal models. Indeed, serotonergic overexpression in early life leads to structural and functional changes in brain circuits that control cognition and emotion. However, the effects of developmental exposure to these substances on the behaviour of adolescent rats are conflicting and remain poorly characterised. We performed a behavioural screening to investigate the effects of postnatal exposure to fluoxetine on memory and behaviours related to anxiety, anhedonia, and depression, as well we evaluate the parvalbumin expression in hippocampus of juvenile (similar to PND45) female and male rats. Fluoxetine (daily 20 mg/kg s.c. injections from PND7-PND21)- or vehicle-treated adolescent rats went through several behavioural tasks (from PND 38 to PND52) and were subject to transcardial perfusion and brain removal for immunohistochemical analysis (PND53). We found that postnatal exposure to fluoxetine increased anxiety- and depression-like behaviours in the open field and sucrose preference and forced swimming tests, respectively. In addition, this treatment induced working memory and short-term (but not long-term) recognition memory impairments, and reduced parvalbumin-positive inter-neurons in the hippocampus. In addition, the results revealed developmental sex-dependent effects of fluoxetine postnatal treatment on adolescent rats' behaviour. These outcomes indicate that affective disorders and mnemonic alterations caused by SSRIs perinatal exposure can be present at adolescence.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- anxiety
- brain development
- depression
- memory
- serotonin
Publication and Content Type
- ref (subject category)
- art (subject category)
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