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  • Zhang, HaojieShanghai Jiao Tong Univ, Inst & Dept Endocrinol & Metab, Shanghai Ninth Peoples Hosp, Sch Med, Shanghai, Peoples R China. (author)

Sleep Patterns, Genetic Susceptibility, and Incident Chronic Kidney Disease : A Prospective Study of 370 671 Participants

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2022-01-31
  • Frontiers Media S.A.2022
  • electronicrdacarrier

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  • LIBRIS-ID:oai:DiVA.org:uu-469213
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-469213URI
  • https://doi.org/10.3389/fnins.2022.725478DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:148770640URI

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  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

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  • ObjectivesUnhealthy sleep behaviors may be potential risk factors for chronic kidney disease (CKD). We aimed to examine the associations of combined sleep patterns and genetic susceptibility with incident CKD. MethodsThis large-scale prospective cohort study included 370,671 participants without CKD at baseline (2006-2010) in UK Biobank data. Five sleep behaviors were made up of sleep duration, insomnia, snoring, chronotype, and daytime sleepiness according to questionnaire. Overall sleep patterns by summing the five scores were created. Weighted genetic risk score of kidney function was calculated. Incident CKD was recorded from death register, primary care, and hospital inpatient records. A subset of 41,130 individuals who participated both the initial assessment visit and follow-up visit (2012+) was also used. ResultsDuring a median follow-up of 10.6 years (about 3.9 million person-years), we documented 6,365 patients with incident CKD. In five sleep behaviors, sleep 7-8 h/day, free of insomnia and no frequent daytime sleepiness were independently associated with incident CKD, with a 12% (95%CI 7-16), 9% (3-14), 13% (9-18) lower risk, respectively. Compared to those with a sleep score of 0-1, participants with a score of 5 had a 21% (10-31%) lower risk of CKD. 17.1% of CKD in this cohort could be attributed to total poor sleep pattern. Participants with high genetic risk and intermediate or poor sleep pattern showed the highest risk of CKD (OR = 2.58, 95%CI 2.24-2.96; OR = 2.59, 95%CI 2.02-3.32, respectively), although there was no significant interaction between sleep patterns and genetic risk categories. Among individuals who participated both the initial assessment visit and follow-up visit, we found that the association between amelioration of sleep pattern and risk of CKD was significant after fully adjustment (OR = 0.60, 95%CI 0.36-0.99), compared with group of stable sleep pattern. ConclusionIn this large prospective study, participants with a healthy sleep pattern was associated with a significant reduction of incident CKD risk no matter they had a high, intermediate, or low genetic risk.

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  • Wang, BinShanghai Jiao Tong Univ, Inst & Dept Endocrinol & Metab, Shanghai Ninth Peoples Hosp, Sch Med, Shanghai, Peoples R China. (author)
  • Chen, ChiShanghai Jiao Tong Univ, Inst & Dept Endocrinol & Metab, Shanghai Ninth Peoples Hosp, Sch Med, Shanghai, Peoples R China. (author)
  • Sun, YingShanghai Jiao Tong Univ, Inst & Dept Endocrinol & Metab, Shanghai Ninth Peoples Hosp, Sch Med, Shanghai, Peoples R China. (author)
  • Chen, JieChinese Univ Hong Kong, Sleep Assessment Unit, Dept Psychiat, Fac Med,Shatin, Hong Kong, Peoples R China. (author)
  • Tan, XiaoKarolinska Institutet,Uppsala universitet,Schiöth: Funktionell farmakologi,Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.(Swepub:uu)xzata683 (author)
  • Xia, FangzhenShanghai Jiao Tong Univ, Inst & Dept Endocrinol & Metab, Shanghai Ninth Peoples Hosp, Sch Med, Shanghai, Peoples R China. (author)
  • Zhang, JihuiGuangdong Acad Med Sci, Guangdong Mental Hlth Ctr, Guangdong Prov Peoples Hosp, Guangzhou, Peoples R China. (author)
  • Lu, YingliShanghai Jiao Tong Univ, Inst & Dept Endocrinol & Metab, Shanghai Ninth Peoples Hosp, Sch Med, Shanghai, Peoples R China. (author)
  • Wang, NingjianShanghai Jiao Tong Univ, Inst & Dept Endocrinol & Metab, Shanghai Ninth Peoples Hosp, Sch Med, Shanghai, Peoples R China. (author)
  • Shanghai Jiao Tong Univ, Inst & Dept Endocrinol & Metab, Shanghai Ninth Peoples Hosp, Sch Med, Shanghai, Peoples R China.Chinese Univ Hong Kong, Sleep Assessment Unit, Dept Psychiat, Fac Med,Shatin, Hong Kong, Peoples R China. (creator_code:org_t)

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  • In:Frontiers in Neuroscience: Frontiers Media S.A.161662-45481662-453X

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By the author/editor
Zhang, Haojie
Wang, Bin
Chen, Chi
Sun, Ying
Chen, Jie
Tan, Xiao
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Xia, Fangzhen
Zhang, Jihui
Lu, Yingli
Wang, Ningjian
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and Neurosciences
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Karolinska Institutet

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