Haploidentical vs sibling, unrelated, or cord blood hematopoietic cell transplantation for acute lymphoblastic leukemia

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Wieduwilt, Matthew J.Univ Oklahoma, Stephenson Canc Ctr, Oklahoma City, OK 73106 USA. (author)

Haploidentical vs sibling, unrelated, or cord blood hematopoietic cell transplantation for acute lymphoblastic leukemia

Article/chapterEnglish2022

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2022-01-11
American Society of Hematology,2022
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LIBRIS-ID:oai:DiVA.org:uu-469231
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-469231URI
https://doi.org/10.1182/bloodadvances.2021004916DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:148866865URI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

The role of haploidentical hematopoietic cell transplantation (HCT) using posttransplant cyclophosphamide (PTCy) for acute lymphoblastic leukemia (ALL) is being defined. We performed a retrospective, multivariable analysis comparing outcomes of HCT approaches by donor for adults with ALL in remission. The primary objective was to compare overall survival (OS) among haploidentical HCTs using PTCy and HLA-matched sibling donor (MSD), 8/8 HLAmatched unrelated donor (MUD), 7 /8 HLA-MUD, or umbilical cord blood (UCB) HCT. Comparing haploidentical HCT to MSD HCT, we found that OS, leukemia-free survival (LFS), nonrelapse mortality (NRM), relapse, and acute graft-versus-host disease (aGVHD) were not different but chronic GVHD (cGVHD) was higher in MSD HCT. Compared with MUD HCT, OS, LFS, and relapse were not different, but MUD HCT had increased NRM (hazard ratio [HR], 1.42; P = .02), grade 3 to 4 aGVHD (HR, 1.59; P = .005), and cGVHD. Compared with 7/8 UD HCT, LFS and relapse were not different, but 7/8 UD HCT had worse OS (HR, 1.38; P = .01) and increased NRM (HR, 2.13; P <_ .001), grade 3 to 4 aGVHD (HR, 1.86; P = .003), and cGVHD (HR, 1.72; P <_ .001). Compared with UCB HCT, late OS, late LFS, relapse, and cGVHD were not different but UCB HCT had worse early OS (<_18 months; HR, 1.93; P < .001), worse early LFS (HR, 1.40; P = .007) and increased incidences of NRM (HR, 2.08; P < .001) and grade 3 to 4 aGVHD (HR, 1.97; P < .001). Haploidentical HCT using PTCy showed no difference in survival but less GVHD compared with traditional MSD and MUD HCT and is the preferred alternative donor HCT option for adults with ALL in complete remission.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Hematologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Hematology hsv//eng

Added entries (persons, corporate bodies, meetings, titles ...)

Metheny, LelandUniv Hosp Seidman Canc Ctr, Cleveland, OH USA. (author)
Zhang, Mei-JieMed Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Inst Hlth & Equ, Div Biostat, Milwaukee, WI 53226 USA. (author)
Wang, Hai-LinMed Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA. (author)
Estrada-Merly, NoelMed Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA. (author)
Marks, David, IUniv Hosp Bristol Natl Hlth Serv Trust, Adult Bone Marrow Transplant, Bristol, Avon, England. (author)
Al-Homsi, A. SamerNew York Univ Langone Hlth, New York, NY USA. (author)
Muffly, LoriStanford Univ, Div Blood & Marrow Transplantat, Stanford, CA 94305 USA. (author)
Chao, NelsonDuke Univ, Med Ctr, Dept Med, Div Cell Therapy & Hematol, Durham, NC 27710 USA. (author)
Rizzieri, DavidDuke Univ, Div Hematol Malignancies & Cellular Therapy, Durham, NC USA. (author)
Gale, Robert PeterImperial Coll London, Haematol Res Ctr, Dept Immunol & Inflammat, London, England. (author)
Gadalla, Shahinaz M.NCI, Div Canc Epidemiol & Genet, Clin Genet Branch, NIH, Rockville, MD USA. (author)
Cairo, MitchellNew York Med Coll, Dept Pediat, Div Pediat Hematol Oncol & Stem Cell Transplantat, Valhalla, NY 10595 USA. (author)
Mussetti, AlbertoInst Catala Oncol Hosp, Hematol Dept, Barcelona, Spain.;Inst Catala Oncol, Inst Invest Biomed Bellvitge, Lhospitalet De Llobregat, El Prat De Llob, Spain. (author)
Gore, StevenYale New Haven Med Ctr, 20 York St, New Haven, CT 06504 USA. (author)
Bhatt, Vijaya RajUniv Nebraska Med Ctr, Fred & Pamela Buffett Canc Ctr, Omaha, NE USA. (author)
Patel, Sagar S.Univ Utah, Huntsman Canc Inst, Blood & Marrow Transplant Program, Salt Lake City, UT USA. (author)
Michelis, Fotios, VPrincess Margaret Canc Ctr, Allogene Blood & Marrow Transplant Program, Toronto, ON, Canada. (author)
Inamoto, YoshihiroNatl Canc Ctr, Div Hematopoiet Stem Cell Transplantat, Tokyo, Japan. (author)
Badawy, Sherif M.Ann & Robert H Lurie Childrens Hosp Chicago, Div Hematol Oncol & Stem Cell Transplant, Chicago, IL 60611 USA.;Northwestern Univ, Dept Pediat, Feinberg Sch Med, Chicago, IL 60611 USA. (author)
Copelan, EdwardAtrium Hlth, Dept Hematol Oncol & Blood Disorders, Levine Canc Inst, Charlotte, NC USA. (author)
Palmisiano, NeilThomas Jefferson Univ, Sidney Kimmel Canc Ctr, Philadelphia, PA 19107 USA. (author)
Kharfan-Dabaja, Mohamed A.Mayo Clin, Blood & Marrow Transplantat Program, Div Hematol Oncol, Jacksonville, FL 32224 USA. (author)
Lazarus, Hillard M.Case Western Reserve Univ, Univ Hosp Cleveland, Med Ctr, Cleveland, OH 44106 USA. (author)
Ganguly, SiddharthaUniv Kansas Hlth Syst, Div Hematol Malignancies & Cellular Therapeut, Kansas City, KS USA. (author)
Bredeson, ChristopherOttawa Hosp, Transplant & Cellular Therapy Program, Ottawa, ON, Canada. (author)
Diaz Perez, Miguel AngelHosp Infantil Univ Nino Jesus, Dept Hematol Oncol, Madrid, Spain. (author)
Cassaday, RyanUniv Washington, Fred Hutchinson Canc Res Ctr, Seattle, WA 98195 USA. (author)
Savani, Bipin N.Vanderbilt Univ, Med Ctr, Dept Med, Div Hematol Oncol, Nashville, TN USA. (author)
Ballen, KarenUniv Virginia Hlth Syst, Div Hematol Oncol, Charlottesville, VA USA. (author)
Martino, RodrigoHosp Santa Creu & Sant Pau, Div Clin Hematol, Barcelona, Spain. (author)
Wirk, BaldeepPenn State Canc Inst, Bone Marrow Transplant Program, Hershey, PA USA. (author)
Bacher, UlrikeUniv Bern, Bern Univ Hosp, Dept Hematol, Inselspital, Bern, Switzerland. (author)
Aljurf, MahmoudKing Faisal Specialist Hosp Ctr & Res, Dept Oncol, Riyadh, Saudi Arabia. (author)
Bashey, AsadNorthside Hosp, Blood & Marrow Transplant Program, Atlanta, GA USA. (author)
Murthy, Hemant S.Mayo Clin, Blood & Marrow Transplantat Program, Div Hematol Oncol, Jacksonville, FL 32224 USA. (author)
Yared, Jean A.Univ Maryland, Dept Med, Greenebaum Comprehens Canc Ctr, Blood & Marrow Transplantat Program,Div Hematol O, Baltimore, MD 21201 USA. (author)
Aldoss, IbrahimCity Hope Med Ctr, Duarte, CA USA. (author)
Farhadfar, NoshaUniv Florida, Div Hematol Oncol, Coll Med, Gainesville, FL USA. (author)
Liu, HongtaoUniv Chicago Med, Sect Hematol Oncol, Chicago, IL USA. (author)
Abdel-Azim, HishamUniv Southern Calif, Childrens Hosp Los Angeles, Div Hematol Oncol & Blood & Marrow Transplantat, Keck Sch Med, Los Angeles, CA 90007 USA. (author)
Waller, Edmund K.Emory Univ, Winship Canc Inst, Dept Hematol & Med Oncol, Atlanta, GA 30322 USA. (author)
Solh, MelhemNorthside Hosp, Blood & Marrow Transplant Grp Georgia, Atlanta, GA USA. (author)
Seftel, Matthew D.Univ British Columbia, Dept Med, Vancouver, BC, Canada. (author)
van der Poel, MarjoleinMaastricht Univ, Med Ctr, Maastricht, Netherlands. (author)
Grunwald, Michael R.Atrium Hlth, Dept Hematol Oncol & Blood Disorders, Levine Canc Inst, Charlotte, NC USA. (author)
Liesveld, Jane L.Univ Rochester, Med Ctr, Dept Med, Rochester, NY 14642 USA. (author)
Kamble, Rammurti T.Baylor Coll Med, Ctr Cell & Gene Therapy, Div Hematol & Oncol, Houston, TX 77030 USA. (author)
McGuirk, JosephUniv Kansas Hlth Syst, Div Hematol Malignancies & Cellular Therapeut, Kansas City, KS USA. (author)
Munker, ReinholdUniv Kentucky, Markey Canc Ctr, Lexington, KY USA. (author)
Cahn, Jean-YvesUniv Grenoble Alpes, Ctr Hosp Univ Grenoble Alpes, Dept Hematol, Grenoble, France. (author)
Lee, Jong WookCatholic Univ Korea, Div Hematol, Seoul St Marys Hosp, Seoul, South Korea. (author)
Freytes, Cesar O.Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. (author)
Krem, Maxwell M.Univ Kentucky, Markey Canc Ctr, Lexington, KY USA. (author)
Winestone, Lena E.Univ Calif San Francisco, Benioff Childrens Hosp, Div Allergy Immunol & Blood & Marrow Transplant, San Francisco, CA 94143 USA. (author)
Gergis, UsamaThomas Jefferson Univ, Div Hematol Malignancies, Dept Med Oncol, Philadelphia, PA 19107 USA. (author)
Nathan, SunitaRush Univ, Med Ctr, Sect Bone Marrow Transplant & Cell Therapy, Chicago, IL 60612 USA. (author)
Olsson, Richard F.Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Inst, Dept Lab Med, Stockholm, Sweden.(Swepub:uu)riols677 (author)
Verdonck, Leo F.Isala Clin, Dept Hematol Oncol, Zwolle, Netherlands. (author)
Sharma, AkshaySt Jude Childrens Res Hosp, Dept Bone Marrow Transplantat & Cellular Therapy, 332 N Lauderdale St, Memphis, TN 38105 USA. (author)
Ringden, OlleKarolinska Institutet (author)
Friend, Brian D.Baylor Coll Med, Ctr Cell & Gene Therapy, Houston, TX 77030 USA. (author)
Cerny, JanUniv Massachusetts, Med Ctr, Dept Med, Div Hematol Oncol, Worcester, MA USA. (author)
Choe, HannahOhio State Univ, James Comprehens Canc Ctr, Wexner Med Ctr, Columbus, OH 43210 USA. (author)
Chhabra, SaurabhMed Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Dept Med, Div Hematol Oncol, Milwaukee, WI 53226 USA. (author)
Nishihori, TaigaH Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplant & Cellular Immunot, Tampa, FL USA. (author)
Seo, SachikoDokkyo Med Univ, Dept Hematol & Oncol, Mibu, Tochigi, Japan. (author)
George, BijuChristian Med Coll & Hosp, Vellore, Tamil Nadu, India. (author)
Baxter-Lowe, Lee AnnChildrens Hosp Los Angeles, Los Angeles, CA 90027 USA. (author)
Hildebrandt, Gerhard C.Univ Kentucky, Markey Canc Ctr, Lexington, KY USA. (author)
de Lima, MarcosUniv Hosp Case Med Ctr, Seidman Canc Ctr, Dept Med, Cleveland, OH USA. (author)
Litzow, MarkMayo Clin Rochester, Div Hematol, Rochester, MN USA.;Mayo Clin Rochester, Transplant Ctr, Rochester, MN USA. (author)
Kebriaei, PartowUniv Texas MD Anderson Canc Ctr, Dept Stem Cell Transplantat, Div Canc Med, Houston, TX 77030 USA. (author)
Hourigan, Christopher S.NHLBI, Lab Myeloid Malignancies, NIH, Bldg 10, Bethesda, MD 20892 USA. (author)
Abid, Muhammad BilalMed Coll Wisconsin, Dept Med, Div Hematol Oncol, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Dept Med, Div Infect Dis, Milwaukee, WI 53226 USA. (author)
Weisdorf, Daniel J.Univ Minnesota, Dept Med, Div Hematol Oncol & Transplantat, Box 736 UMHC, Minneapolis, MN 55455 USA. (author)
Saber, WaelMed Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA. (author)
Univ Oklahoma, Stephenson Canc Ctr, Oklahoma City, OK 73106 USA.Univ Hosp Seidman Canc Ctr, Cleveland, OH USA. (creator_code:org_t)

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In:Blood Advances: American Society of Hematology6:1, s. 339-3572473-95292473-9537

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By the author/editor: Wieduwilt, Matth ...; Metheny, Leland; Zhang, Mei-Jie; Wang, Hai-Lin; Estrada-Merly, N ...; Marks, David, I; show more...; Al-Homsi, A. Sam ...; Muffly, Lori; Chao, Nelson; Rizzieri, David; Gale, Robert Pet ...; Gadalla, Shahina ...; Cairo, Mitchell; Mussetti, Albert ...; Gore, Steven; Bhatt, Vijaya Ra ...; Patel, Sagar S.; Michelis, Fotios ...; Inamoto, Yoshihi ...; Badawy, Sherif M ...; Copelan, Edward; Palmisiano, Neil; Kharfan-Dabaja, ...; Lazarus, Hillard ...; Ganguly, Siddhar ...; Bredeson, Christ ...; Diaz Perez, Migu ...; Cassaday, Ryan; Savani, Bipin N.; Ballen, Karen; Martino, Rodrigo; Wirk, Baldeep; Bacher, Ulrike; Aljurf, Mahmoud; Bashey, Asad; Murthy, Hemant S ...; Yared, Jean A.; Aldoss, Ibrahim; Farhadfar, Nosha; Liu, Hongtao; Abdel-Azim, Hish ...; Waller, Edmund K ...; Solh, Melhem; Seftel, Matthew ...; van der Poel, Ma ...; Grunwald, Michae ...; Liesveld, Jane L ...; Kamble, Rammurti ...; McGuirk, Joseph; Munker, Reinhold; Cahn, Jean-Yves; Lee, Jong Wook; Freytes, Cesar O ...; Krem, Maxwell M.; Winestone, Lena ...; Gergis, Usama; Nathan, Sunita; Olsson, Richard ...; Verdonck, Leo F.; Sharma, Akshay; Ringden, Olle; Friend, Brian D.; Cerny, Jan; Choe, Hannah; Chhabra, Saurabh; Nishihori, Taiga; Seo, Sachiko; George, Biju; Baxter-Lowe, Lee ...; Hildebrandt, Ger ...; de Lima, Marcos; Litzow, Mark; Kebriaei, Partow; Hourigan, Christ ...; Abid, Muhammad B ...; Weisdorf, Daniel ...; Saber, Wael; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Hematology

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