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  • Furthner, DieterSalzkammergutklinikum Voecklabruck, Dept Pediat, Voecklabruck, Austria.;Paracelsus Med Univ, Univ Hosp Salzburg, Obes Res Unit, Salzburg, Austria. (author)

Single Point Insulin Sensitivity Estimator in Pediatric Non-Alcoholic Fatty Liver Disease

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2022-02-02
  • Frontiers Media S.A.2022
  • electronicrdacarrier

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  • LIBRIS-ID:oai:DiVA.org:uu-469573
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-469573URI
  • https://doi.org/10.3389/fendo.2022.830012DOI

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  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

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  • BackgroundAttenuated insulin-sensitivity (IS) is a central feature of pediatric non-alcoholic fatty liver disease (NAFLD). We recently developed a new index, single point insulin sensitivity estimator (SPISE), based on triglycerides, high-density-lipoprotein and body-mass-index (BMI), and validated by euglycemic-hyperinsulinemic clamp-test (EHCT) in adolescents. This study aims to assess the performance of SPISE as an estimation of hepatic insulin (in-)sensitivity. Our results introduce SPISE as a novel and inexpensive index of hepatic insulin resistance, superior to established indices in children and adolescents with obesity. Materials and MethodsNinety-nine pubertal subjects with obesity (13.5 +/- 2.0 years, 59.6% males, overall mean BMI-SDS + 2.8 +/- 0.6) were stratified by MRI (magnetic resonance imaging) into a NAFLD (>5% liver-fat-content; male n=41, female n=16) and non-NAFLD (<= 5%; male n=18, female n=24) group. Obesity was defined according to WHO criteria (> 2 BMI-SDS). EHCT were used to determine IS in a subgroup (n=17). Receiver-operating-characteristic (ROC)-curve was performed for diagnostic ability of SPISE, HOMA-IR (homeostatic model assessment for insulin resistance), and HIRI (hepatic insulin resistance index), assuming null hypothesis of no difference in area-under-the-curve (AUC) at 0.5. ResultsSPISE was lower in NAFLD (male: 4.8 +/- 1.2, female: 4.5 +/- 1.1) than in non-NAFLD group (male 6.0 +/- 1.6, female 5.6 +/- 1.5; P< 0.05 {95% confidence interval [CI]: male NAFLD 4.5, 5.2; male non-NAFLD 5.2, 6.8; female NAFLD 4.0, 5.1, female non-NAFLD 5.0, 6.2}). In males, ROC-AUC was 0.71 for SPISE (P=0.006, 95% CI: 0.54, 0.87), 0.68 for HOMA-IR (P=0.038, 95% CI: 0.48, 0.88), and 0.50 for HIRI (P=0.543, 95% CI: 0.27, 0.74). In females, ROC-AUC was 0.74 for SPISE (P=0.006), 0.59 for HOMA-IR (P=0.214), and 0.68 for HIRI (P=0.072). The optimal cutoff-level for SPISE between NAFLD and non-NAFLD patients was 5.18 overall (Youden-index: 0.35; sensitivity 0.68%, specificity 0.67%). ConclusionSPISE is significantly lower in juvenile patients with obesity-associated NAFLD. Our results suggest that SPISE indicates hepatic IR in pediatric NAFLD patients with sensitivity and specificity superior to established indices of hepatic IR.

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  • Anderwald, Christian-HeinzParacelsus Med Univ, Univ Hosp Salzburg, Obes Res Unit, Salzburg, Austria.;Med Univ Vienna, Div Endocrinol & Metab, Dept Internal Med 3, Vienna, Austria.;Arnoldstein Healthcare Ctr, Arnoldstein, Austria. (author)
  • Bergsten, PeterUppsala universitet,Institutionen för medicinsk cellbiologi(Swepub:uu)peteberg (author)
  • Forslund, Anders,1961-Uppsala universitet,Institutionen för kvinnors och barns hälsa(Swepub:uu)andeforsl (author)
  • Kullberg, Joel,1979-Uppsala universitet,Geriatrik,Radiologi(Swepub:uu)jokul377 (author)
  • Ahlström, Håkan,1953-Uppsala universitet,Radiologi(Swepub:uu)hakanahl (author)
  • Manell, HannesUppsala universitet,Institutionen för medicinsk cellbiologi(Swepub:uu)hanoh982 (author)
  • Ciba, IrisUppsala universitet,Institutionen för kvinnors och barns hälsa(Swepub:uu)irici655 (author)
  • Mangge, HaraldMed Univ Graz, Clin Inst Med & Chem Lab Diag, Graz, Austria. (author)
  • Maruszczak, KatharinaParacelsus Med Univ, Univ Hosp Salzburg, Obes Res Unit, Salzburg, Austria.;Paracelsus Med Univ, Univ Hosp Salzburg, Dept Pediat, Salzburg, Austria. (author)
  • Koren, PiaParacelsus Med Univ, Univ Hosp Salzburg, Obes Res Unit, Salzburg, Austria.;Paracelsus Med Univ, Univ Hosp Salzburg, Dept Pediat, Salzburg, Austria. (author)
  • Schuetz, SebastianParacelsus Med Univ, Univ Hosp Salzburg, Obes Res Unit, Salzburg, Austria.;Paracelsus Med Univ, Univ Hosp Salzburg, Dept Pediat, Salzburg, Austria. (author)
  • Brunner, Susanne MariaParacelsus Med Univ, Dept Pediat, Res Program Receptor Biochem & Tumor Metab, Univ Hosp, Salzburg, Austria. (author)
  • Schneider, Anna MariaParacelsus Med Univ, Univ Hosp Salzburg, Obes Res Unit, Salzburg, Austria.;Paracelsus Med Univ, Univ Hosp Salzburg, Dept Pediat, Salzburg, Austria. (author)
  • Weghuber, DanielParacelsus Med Univ, Univ Hosp Salzburg, Obes Res Unit, Salzburg, Austria.;Paracelsus Med Univ, Univ Hosp Salzburg, Dept Pediat, Salzburg, Austria. (author)
  • Moerwald, KatharinaParacelsus Med Univ, Univ Hosp Salzburg, Obes Res Unit, Salzburg, Austria.;Paracelsus Med Univ, Univ Hosp Salzburg, Dept Pediat, Salzburg, Austria. (author)
  • Salzkammergutklinikum Voecklabruck, Dept Pediat, Voecklabruck, Austria.;Paracelsus Med Univ, Univ Hosp Salzburg, Obes Res Unit, Salzburg, Austria.Paracelsus Med Univ, Univ Hosp Salzburg, Obes Res Unit, Salzburg, Austria.;Med Univ Vienna, Div Endocrinol & Metab, Dept Internal Med 3, Vienna, Austria.;Arnoldstein Healthcare Ctr, Arnoldstein, Austria. (creator_code:org_t)

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  • In:Frontiers in Endocrinology: Frontiers Media S.A.131664-2392

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