Search: WFRF:(Borres Magnus)
> (2020-2023) >
Prevalence and earl...
Prevalence and early-life risk factors for tree nut sensitization and allergy in young adults
-
- Bager, Jessica (author)
- Karolinska Inst, Dept Womens & Childrens Hlth, SE-17177 Stockholm, Sweden.
-
- Tedner, Sandra G. (author)
- Karolinska Institutet,Karolinska Inst, Dept Womens & Childrens Hlth, SE-17177 Stockholm, Sweden.;Karolinska Univ Hosp, Astrid Lindgren Childrens Hosp, Pediat Allergy & Pulmonol Unit, Stockholm, Sweden.
-
- Andersson, Niklas (author)
- Karolinska Institutet,Karolinska Inst, Inst Environm Med, Stockholm, Sweden.
-
show more...
-
- Ballardini, Natalia (author)
- Karolinska Institutet,Sachs Children & Youth Hosp, Stockholm, Sweden.;Karolinska Inst, Dept Clin Sci & Educ Sodersjukhuset, Stockholm, Sweden.;Dept Dermatol & Sexual Hlth, Stockholm, Sweden.
-
- Borres, Magnus P, 1956- (author)
- Uppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa,Uppsala Univ, Dept Womens & Childrens Hlth, Uppsala, Sweden.;Thermo Fisher Sci, Uppsala, Sweden.
-
- Konradsen, Jon R. (author)
- Karolinska Institutet,Karolinska Inst, Dept Womens & Childrens Hlth, SE-17177 Stockholm, Sweden.;Karolinska Univ Hosp, Astrid Lindgren Childrens Hosp, Pediat Allergy & Pulmonol Unit, Stockholm, Sweden.
-
- Nilsson, Caroline (author)
- Karolinska Institutet,Sachs Children & Youth Hosp, Stockholm, Sweden.;Karolinska Inst, Dept Clin Sci & Educ Sodersjukhuset, Stockholm, Sweden.
-
- Westman, Marit (author)
- Karolinska Inst, Div Immunol & Allergy, Dept Med Solna, Stockholm, Sweden.;Karolinska Univ Hosp, Stockholm, Sweden.;Asthma & Allergy Clin St Goran, Stockholm, Sweden.
-
- Kull, Inger (author)
- Karolinska Institutet,Sachs Children & Youth Hosp, Stockholm, Sweden.;Karolinska Inst, Dept Clin Sci & Educ Sodersjukhuset, Stockholm, Sweden.
-
- Bergstrom, Anna (author)
- Karolinska Institutet,Karolinska Inst, Inst Environm Med, Stockholm, Sweden.;Ctr Occupat & Environm Med, Stockholm, Sweden.
-
- van Hage, Marianne (author)
- Karolinska Inst, Div Immunol & Allergy, Dept Med Solna, Stockholm, Sweden.;Karolinska Univ Hosp, Stockholm, Sweden.
-
- Melen, Erik (author)
- Karolinska Institutet,Karolinska Inst, Inst Environm Med, Stockholm, Sweden.;Sachs Children & Youth Hosp, Stockholm, Sweden.;Karolinska Inst, Dept Clin Sci & Educ Sodersjukhuset, Stockholm, Sweden.
-
- Asarnoj, Anna (author)
- Karolinska Institutet,Karolinska Inst, Dept Womens & Childrens Hlth, SE-17177 Stockholm, Sweden.;Karolinska Univ Hosp, Astrid Lindgren Childrens Hosp, Pediat Allergy & Pulmonol Unit, Stockholm, Sweden.
-
show less...
-
Karolinska Institutet Karolinska Inst, Dept Womens & Childrens Hlth, SE-17177 Stockholm, Sweden (creator_code:org_t)
- 2021-08-06
- 2021
- English.
-
In: Clinical and Experimental Allergy. - : John Wiley & Sons. - 0954-7894 .- 1365-2222. ; 51:11, s. 1429-1437
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://onlinelibrar...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- Background Tree nut allergy may cause anaphylaxis. There are limited population-based studies on prevalence and early-life risk factors. Methods We evaluated the prevalence of reported symptoms and allergic sensitization to tree nuts at age 24 years in the BAMSE population-based cohort study and assessed early-life factors associated with the development of tree nut allergy. We estimated tree nut allergy prevalence, by analysing questionnaire data on tree nut ingestion and symptoms at age 12, 16 and 24 years, and IgE sensitization at age 24 years to hazelnut, walnut, pecan, cashew, pistachio, Brazil nut, almond extracts and allergen molecules Cor a 1, 9, 14 (hazelnut), Jug r 1 (walnut) and Ana o 3 (cashew). We evaluated eczema, asthma, food allergies, inherited risk of allergy and gender as potential early-life risk factors. Results Data were available for 2215/4089 (54%) BAMSE study participants, for estimation of the prevalence of tree nut sensitization (21.2%), tree nut allergy symptoms (9.8%) and combined sensitization and symptoms (7.9%, 2.1% for storage protein sensitization and symptoms, 4.3% for any sensitization and non-mild symptoms). Sixty-three per cent of sensitized individuals (295/470) were asymptomatic, but only 76/470 (16%) storage protein sensitized individuals. Egg allergy (ORadj 8.50 95% CI 2.15-33.6), eczema (ORadj 2.53 95% CI 1.21-5.32) and asthma (ORadj 5.59 95% CI 2.35-13.3)) at pre-school age were associated with future development of tree nut symptoms and storage protein sensitization. At age 24 years, tree nut allergy was associated with current eczema and with markers of current asthma severity. Sensitization to storage proteins was more strongly associated with symptoms than sensitization to whole extract for all tree nuts evaluated. Conclusions In this Swedish cohort, we found tree nut whole extract sensitization is common but usually asymptomatic. Storage protein sensitization is a more reliable indicator of tree nut symptoms. Tree nut allergy is associated with early onset, persistent and severe atopic disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Keyword
- Ana o 3
- BAMSE
- birth cohort
- Cor a 1
- Cor a 14
- Cor a 9
- Jug r 1
- molecular allergology
- sensitization
- tree nut allergy
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Bager, Jessica
-
Tedner, Sandra G ...
-
Andersson, Nikla ...
-
Ballardini, Nata ...
-
Borres, Magnus P ...
-
Konradsen, Jon R ...
-
show more...
-
Nilsson, Carolin ...
-
Westman, Marit
-
Kull, Inger
-
Bergstrom, Anna
-
van Hage, Marian ...
-
Melen, Erik
-
Asarnoj, Anna
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Respiratory Medi ...
- Articles in the publication
-
Clinical and Exp ...
- By the university
-
Uppsala University
-
Karolinska Institutet