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Propensity Score an...
Propensity Score and Desirability of Outcome Ranking Analysis of Ertapenem for Treatment of Nonsevere Bacteremic Urinary Tract Infections Due to Extended-Spectrum-Beta-Lactamase-Producing Enterobacterales in Kidney Transplant Recipients
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- Gutierrez-Gutierrez, Belen (author)
- Spanish Network Res Infect Dis REIPI, Madrid, Spain.;Univ Seville, Virgen Macarena Univ Hosp, Inst Biomed Seville, Clin Unit Infect Dis & Microbiol, Seville, Spain.
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- Perez-Nadales, Elena (author)
- Spanish Network Res Infect Dis REIPI, Madrid, Spain.;Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Biomed Res Inst Cordoba IMIBIC, Cordoba, Spain.
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- Perez-Galera, Salvador (author)
- Virgen Macarena Univ Hosp, Clin Unit Internal Med, Seville, Spain.
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- Fernandez-Ruiz, Mario (author)
- Spanish Network Res Infect Dis REIPI, Madrid, Spain.;Univ Complutense, Inst Invest Sanitaria Hosp 12 Octubre Imas12, Unit Infect Dis, 12 Octubre Univ Hosp, Madrid, Spain.
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- Carratala, Jordi (author)
- Univ Barcelona, Bellvitge Univ Hosp, Bellvitge Biomed Res Inst IDIBELL, Dept Infect Dis, Barcelona, Spain.
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- Oriol, Isabel (author)
- Univ Barcelona, Bellvitge Univ Hosp, Bellvitge Biomed Res Inst IDIBELL, Dept Infect Dis, Barcelona, Spain.
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- Cordero, Elisa (author)
- Virgen del Rocio Univ Hosp, Clin Unit Infect Dis Microbiol & Prevent Med, Seville, Spain.
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- Antonio Lepe, Jose (author)
- Virgen del Rocio Univ Hosp, Clin Unit Infect Dis Microbiol & Prevent Med, Seville, Spain.
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- Tan, Ban Hock (author)
- Singapore Gen Hosp, Dept Infect Dis, Singapore, Singapore.
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- Corbella, Laura (author)
- Univ Complutense, Inst Invest Sanitaria Hosp 12 Octubre Imas12, Unit Infect Dis, 12 Octubre Univ Hosp, Madrid, Spain.
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- Paul, Mical (author)
- Rambam Hlth Care Campus, Infect Dis Inst, Haifa, Israel.
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- Natera, Alejandra M. (author)
- Spanish Network Res Infect Dis REIPI, Madrid, Spain.;Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Biomed Res Inst Cordoba IMIBIC, Cordoba, Spain.
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- David, Miruna D. (author)
- Univ Hosp Birmingham NHS Fdn Trust, Birmingham, W Midlands, England.
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- Montejo, Miguel (author)
- Cruces Univ Hosp, Infect Dis Unit, Bilbao, Spain.
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- Iyer, Ranganathan N. (author)
- Global Hosp, Clin Microbiol Identificat & Infect Control, Hyderabad, India.
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- Pierrotti, Ligia Camera (author)
- Univ Sao Paulo, Hosp Clin, Infect Dis Div, Med Sch, Sao Paulo, Brazil.
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- Merino, Esperanza (author)
- Gen Univ Hosp Alicante, Unit Infect Dis, ISABIAL, Alicante, Spain.
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- Steinke, Seema Mehta (author)
- Johns Hopkins Univ, Sch Med, Baltimore, MD USA.
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- Rana, Meenakshi M. (author)
- Icahn Sch Med Mt Sinai, New York, NY 10029 USA.
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- Munoz, Patricia (author)
- Univ Complutense Madrid, Serv Microbiol Clin & Enfermedades Infecciosas, Hosp Gen Univ Gregorio Maranon,CIBER Enfermedades, Inst Invest Sanitaria Gregorio Maranon,Fac Med, Madrid, Spain.
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- Mularoni, Alessandra (author)
- IRCCS ISMETT, Palermo, Italy.
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- van Delden, Christian (author)
- Univ Hosp Geneva, Unit Transplant Infect Dis, Geneva, Switzerland.;Swiss Transplant Cohort Study STCS, Geneva, Switzerland.
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- Grossi, Paolo Antonio (author)
- Univ Insubria, Varese Natl Ctr Transplantat, Dept Med & Surg, Infect Dis Sect, Rome, Italy.
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- Seminari, Elena Maria (author)
- Fdn IRCCS Policlin San Matteo Pavia, Div Infect Dis, Pavia, Italy.
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- Gunseren, Filiz (author)
- Akdeniz Univ, Dept Infect Dis & Clin Microbiol, Fac Med, Antalya, Turkey.
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- Lease, Erika D. (author)
- Univ Washington, Div Pulm Crit Care & Sleep Med, Seattle, WA 98195 USA.
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- Roilides, Emmanuel (author)
- Aristotle Univ Thessaloniki, Sch Hlth Sci, Hippokrat Gen Hosp, Fac Med,Infect Dis Unit, Thessaloniki, Greece.;Aristotle Univ Thessaloniki, Sch Hlth Sci, Hippokrat Gen Hosp, Fac Med,Dept Pediat 3, Thessaloniki, Greece.
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- Fortun, Jesus (author)
- Ramon y Cajal Univ Hosp, Madrid, Spain.
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- Arslan, Hande (author)
- Bakent Univ, Sch Med, Ankara, Turkey.
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- Coussement, Julien (author)
- Univ Libre Bruxelles, Div Infect Dis, CUB Hop Erasme, Brussels, Belgium.
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- Tufan, Zeliha Kocak (author)
- Ankara Yildirim Beyazit Univ, Infect Dis & Clin Microbiol Dept, Med Sch, Ankara, Turkey.
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- Pilmis, Benoit (author)
- Paris Descartes Univ, Necker Enfants Malad Univ Hosp, AP HP,Inst Imagine, Dept Infect Dis & Trop Med,Ctr Infectiol Necker P, Paris, France.
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- Rizzi, Marco (author)
- ASST Papa Giovanni XXIII, Infect Dis Unit, Bergamo, Italy.
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- Loeches, Belen (author)
- Hosp La Paz, Infect Dis Unit, Madrid, Spain.
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- Eriksson, Britt-Marie, Docent, 1952- (author)
- Uppsala universitet,Infektionssjukdomar
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- Abdala, Edson (author)
- Univ Sao Paulo, Fac Med, Sao Paulo, Brazil.
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- Soldani, Fabio (author)
- Azienda Osped Univ Integrata Verona, Dept Med, Infect Dis Unit, Verona, Italy.
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- Lowman, Warren (author)
- Univ Witwatersrand, Fac Hlth Sci, Wits Donald Gordon Med Ctr, Pathcare Vermaak, Johannesburg, South Africa.
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- Clemente, Wanessa Trindade (author)
- Univ Fed Minas Gerais HC UFMG, Hosp Clin, Fac Med, Inst Alfa Gastroenterol,Grp Transplante Figado, Belo Horizonte, MG, Brazil.
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- Bodro, Marta (author)
- Univ Barcelona, Hosp Clin IDIBAPS, Infect Dis Dept, Barcelona, Spain.
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- Carmen Farinas, Maria (author)
- Univ Cantabria, Hosp Univ Marques de Valdecilla, Infect Dis Unit, Santander, Spain.
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- Kazak, Esra (author)
- Uludag Univ, Bursa, Turkey.
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- Martinez-Martinez, Luis (author)
- Spanish Network Res Infect Dis REIPI, Madrid, Spain.;Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Biomed Res Inst Cordoba IMIBIC, Dept Microbiol,Clin Unit Microbiol, Cordoba, Spain.
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- Maria Aguado, Jose (author)
- Spanish Network Res Infect Dis REIPI, Madrid, Spain.;Univ Complutense, Inst Invest Sanitaria Hosp 12 Octubre Imas12, Unit Infect Dis, 12 Octubre Univ Hosp, Madrid, Spain.
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- Torre-Cisneros, Julian (author)
- Spanish Network Res Infect Dis REIPI, Madrid, Spain.;Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Biomed Res Inst Cordoba IMIBIC, Clin Unit Infect Dis, Cordoba, Spain.
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- Pascual, Alvaro (author)
- Spanish Network Res Infect Dis REIPI, Madrid, Spain.;Univ Seville, Virgen Macarena Univ Hosp, Inst Biomed Seville, Clin Unit Infect Dis & Microbiol, Seville, Spain.
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- Rodriguez-Bano, Jesus (author)
- Spanish Network Res Infect Dis REIPI, Madrid, Spain.;Univ Seville, Virgen Macarena Univ Hosp, Inst Biomed Seville, Clin Unit Infect Dis & Microbiol, Seville, Spain.
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Spanish Network Res Infect Dis REIPI, Madrid, Spain;Univ Seville, Virgen Macarena Univ Hosp, Inst Biomed Seville, Clin Unit Infect Dis & Microbiol, Seville, Spain. Spanish Network Res Infect Dis REIPI, Madrid, Spain.;Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Biomed Res Inst Cordoba IMIBIC, Cordoba, Spain. (creator_code:org_t)
- American Society for Microbiology, 2021
- 2021
- English.
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In: Antimicrobial Agents and Chemotherapy. - : American Society for Microbiology. - 0066-4804 .- 1098-6596. ; 65:11
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- There are scarce data on the efficacy of ertapenem in the treatment of bacteremia due to extended-spectrum-beta-lactamase (ESBL)-producing Enterobacterales (ESBL-E) in kidney transplant (KT) recipients. We evaluated the association between treatment with ertapenem or meropenem and clinical cure in KT recipients with nonsevere bacteremic urinary tract infections (B-UTI) caused by ESBL-E. We performed a registered, retrospective, international (29 centers in 14 countries) cohort study (INCREMENT-SOT, NCT02852902). The association between targeted therapy with ertapenem versus meropenem and clinical cure at day 14 (the principal outcome) was studied by logistic regression. Propensity score matching and desirability of outcome ranking (DOOR) analyses were also performed. A total of 201 patients were included; only 1 patient (treated with meropenem) in the cohort died. Clinical cure at day 14 was reached in 45/100 (45%) and 51/101 (50.5%) of patients treated with ertapenem and meropenem, respectively (adjusted OR 1.29; 95% CI 0.51 to 3.22; P = 0.76); the propensity score-matched cohort included 55 pairs (adjusted OR for clinical cure at day 14, 1.18; 95% CI 0.43 to 3.29; P = 0.74). In this cohort, the proportion of cases treated with ertapenem with better DOOR than with meropenem was 49.7% (95% CI, 40.4 to 59.1%) when hospital stay was considered. It ranged from 59 to 67% in different scenarios of a modified (weights-based) DOOR sensitivity analysis when potential ecological advantage or cost was considered in addition to outcome. In conclusion, targeted therapy with ertapenem appears as effective as meropenem to treat nonsevere B-UTI due to ESBL-E in KT recipients and may have some advantages.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Keyword
- ertapenem
- extended-spectrum-beta-lactamase-producing Enterobacterales
- ESBL-E
- urinary tract infection
- UTI
- bloodstream infection
- BSI
- kidney transplant
Publication and Content Type
- ref (subject category)
- art (subject category)
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Gutierrez-Gutier ...
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Perez-Nadales, E ...
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Perez-Galera, Sa ...
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Fernandez-Ruiz, ...
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Carratala, Jordi
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Oriol, Isabel
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Cordero, Elisa
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Antonio Lepe, Jo ...
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Tan, Ban Hock
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Corbella, Laura
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Paul, Mical
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Natera, Alejandr ...
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David, Miruna D.
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Montejo, Miguel
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Iyer, Ranganatha ...
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Pierrotti, Ligia ...
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Merino, Esperanz ...
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Steinke, Seema M ...
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Rana, Meenakshi ...
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Munoz, Patricia
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Mularoni, Alessa ...
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van Delden, Chri ...
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Grossi, Paolo An ...
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Seminari, Elena ...
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Gunseren, Filiz
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Lease, Erika D.
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Roilides, Emmanu ...
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Fortun, Jesus
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Arslan, Hande
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Coussement, Juli ...
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Tufan, Zeliha Ko ...
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Pilmis, Benoit
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Rizzi, Marco
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Loeches, Belen
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Eriksson, Britt- ...
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Abdala, Edson
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Soldani, Fabio
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Lowman, Warren
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Clemente, Waness ...
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Bodro, Marta
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Carmen Farinas, ...
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Kazak, Esra
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Martinez-Martine ...
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Maria Aguado, Jo ...
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Torre-Cisneros, ...
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Pascual, Alvaro
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Rodriguez-Bano, ...
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Uppsala University