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Propensity Score an...
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Gutierrez-Gutierrez, BelenSpanish Network Res Infect Dis REIPI, Madrid, Spain.;Univ Seville, Virgen Macarena Univ Hosp, Inst Biomed Seville, Clin Unit Infect Dis & Microbiol, Seville, Spain.
(author)
Propensity Score and Desirability of Outcome Ranking Analysis of Ertapenem for Treatment of Nonsevere Bacteremic Urinary Tract Infections Due to Extended-Spectrum-Beta-Lactamase-Producing Enterobacterales in Kidney Transplant Recipients
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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American Society for Microbiology,2021
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-470107
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-470107URI
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https://doi.org/10.1128/AAC.01102-21DOI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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There are scarce data on the efficacy of ertapenem in the treatment of bacteremia due to extended-spectrum-beta-lactamase (ESBL)-producing Enterobacterales (ESBL-E) in kidney transplant (KT) recipients. We evaluated the association between treatment with ertapenem or meropenem and clinical cure in KT recipients with nonsevere bacteremic urinary tract infections (B-UTI) caused by ESBL-E. We performed a registered, retrospective, international (29 centers in 14 countries) cohort study (INCREMENT-SOT, NCT02852902). The association between targeted therapy with ertapenem versus meropenem and clinical cure at day 14 (the principal outcome) was studied by logistic regression. Propensity score matching and desirability of outcome ranking (DOOR) analyses were also performed. A total of 201 patients were included; only 1 patient (treated with meropenem) in the cohort died. Clinical cure at day 14 was reached in 45/100 (45%) and 51/101 (50.5%) of patients treated with ertapenem and meropenem, respectively (adjusted OR 1.29; 95% CI 0.51 to 3.22; P = 0.76); the propensity score-matched cohort included 55 pairs (adjusted OR for clinical cure at day 14, 1.18; 95% CI 0.43 to 3.29; P = 0.74). In this cohort, the proportion of cases treated with ertapenem with better DOOR than with meropenem was 49.7% (95% CI, 40.4 to 59.1%) when hospital stay was considered. It ranged from 59 to 67% in different scenarios of a modified (weights-based) DOOR sensitivity analysis when potential ecological advantage or cost was considered in addition to outcome. In conclusion, targeted therapy with ertapenem appears as effective as meropenem to treat nonsevere B-UTI due to ESBL-E in KT recipients and may have some advantages.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Perez-Nadales, ElenaSpanish Network Res Infect Dis REIPI, Madrid, Spain.;Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Biomed Res Inst Cordoba IMIBIC, Cordoba, Spain.
(author)
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Perez-Galera, SalvadorVirgen Macarena Univ Hosp, Clin Unit Internal Med, Seville, Spain.
(author)
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Fernandez-Ruiz, MarioSpanish Network Res Infect Dis REIPI, Madrid, Spain.;Univ Complutense, Inst Invest Sanitaria Hosp 12 Octubre Imas12, Unit Infect Dis, 12 Octubre Univ Hosp, Madrid, Spain.
(author)
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Carratala, JordiUniv Barcelona, Bellvitge Univ Hosp, Bellvitge Biomed Res Inst IDIBELL, Dept Infect Dis, Barcelona, Spain.
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Oriol, IsabelUniv Barcelona, Bellvitge Univ Hosp, Bellvitge Biomed Res Inst IDIBELL, Dept Infect Dis, Barcelona, Spain.
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Cordero, ElisaVirgen del Rocio Univ Hosp, Clin Unit Infect Dis Microbiol & Prevent Med, Seville, Spain.
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Antonio Lepe, JoseVirgen del Rocio Univ Hosp, Clin Unit Infect Dis Microbiol & Prevent Med, Seville, Spain.
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Tan, Ban HockSingapore Gen Hosp, Dept Infect Dis, Singapore, Singapore.
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Corbella, LauraUniv Complutense, Inst Invest Sanitaria Hosp 12 Octubre Imas12, Unit Infect Dis, 12 Octubre Univ Hosp, Madrid, Spain.
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Paul, MicalRambam Hlth Care Campus, Infect Dis Inst, Haifa, Israel.
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Natera, Alejandra M.Spanish Network Res Infect Dis REIPI, Madrid, Spain.;Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Biomed Res Inst Cordoba IMIBIC, Cordoba, Spain.
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David, Miruna D.Univ Hosp Birmingham NHS Fdn Trust, Birmingham, W Midlands, England.
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Montejo, MiguelCruces Univ Hosp, Infect Dis Unit, Bilbao, Spain.
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Iyer, Ranganathan N.Global Hosp, Clin Microbiol Identificat & Infect Control, Hyderabad, India.
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Pierrotti, Ligia CameraUniv Sao Paulo, Hosp Clin, Infect Dis Div, Med Sch, Sao Paulo, Brazil.
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Merino, EsperanzaGen Univ Hosp Alicante, Unit Infect Dis, ISABIAL, Alicante, Spain.
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Steinke, Seema MehtaJohns Hopkins Univ, Sch Med, Baltimore, MD USA.
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Rana, Meenakshi M.Icahn Sch Med Mt Sinai, New York, NY 10029 USA.
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Munoz, PatriciaUniv Complutense Madrid, Serv Microbiol Clin & Enfermedades Infecciosas, Hosp Gen Univ Gregorio Maranon,CIBER Enfermedades, Inst Invest Sanitaria Gregorio Maranon,Fac Med, Madrid, Spain.
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Mularoni, AlessandraIRCCS ISMETT, Palermo, Italy.
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van Delden, ChristianUniv Hosp Geneva, Unit Transplant Infect Dis, Geneva, Switzerland.;Swiss Transplant Cohort Study STCS, Geneva, Switzerland.
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Grossi, Paolo AntonioUniv Insubria, Varese Natl Ctr Transplantat, Dept Med & Surg, Infect Dis Sect, Rome, Italy.
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Seminari, Elena MariaFdn IRCCS Policlin San Matteo Pavia, Div Infect Dis, Pavia, Italy.
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Gunseren, FilizAkdeniz Univ, Dept Infect Dis & Clin Microbiol, Fac Med, Antalya, Turkey.
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Lease, Erika D.Univ Washington, Div Pulm Crit Care & Sleep Med, Seattle, WA 98195 USA.
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Roilides, EmmanuelAristotle Univ Thessaloniki, Sch Hlth Sci, Hippokrat Gen Hosp, Fac Med,Infect Dis Unit, Thessaloniki, Greece.;Aristotle Univ Thessaloniki, Sch Hlth Sci, Hippokrat Gen Hosp, Fac Med,Dept Pediat 3, Thessaloniki, Greece.
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Fortun, JesusRamon y Cajal Univ Hosp, Madrid, Spain.
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Arslan, HandeBakent Univ, Sch Med, Ankara, Turkey.
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Coussement, JulienUniv Libre Bruxelles, Div Infect Dis, CUB Hop Erasme, Brussels, Belgium.
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Tufan, Zeliha KocakAnkara Yildirim Beyazit Univ, Infect Dis & Clin Microbiol Dept, Med Sch, Ankara, Turkey.
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Pilmis, BenoitParis Descartes Univ, Necker Enfants Malad Univ Hosp, AP HP,Inst Imagine, Dept Infect Dis & Trop Med,Ctr Infectiol Necker P, Paris, France.
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Rizzi, MarcoASST Papa Giovanni XXIII, Infect Dis Unit, Bergamo, Italy.
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Loeches, BelenHosp La Paz, Infect Dis Unit, Madrid, Spain.
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Eriksson, Britt-Marie,Docent,1952-Uppsala universitet,Infektionssjukdomar(Swepub:uu)breri424
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Abdala, EdsonUniv Sao Paulo, Fac Med, Sao Paulo, Brazil.
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Soldani, FabioAzienda Osped Univ Integrata Verona, Dept Med, Infect Dis Unit, Verona, Italy.
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Lowman, WarrenUniv Witwatersrand, Fac Hlth Sci, Wits Donald Gordon Med Ctr, Pathcare Vermaak, Johannesburg, South Africa.
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Clemente, Wanessa TrindadeUniv Fed Minas Gerais HC UFMG, Hosp Clin, Fac Med, Inst Alfa Gastroenterol,Grp Transplante Figado, Belo Horizonte, MG, Brazil.
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Bodro, MartaUniv Barcelona, Hosp Clin IDIBAPS, Infect Dis Dept, Barcelona, Spain.
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Carmen Farinas, MariaUniv Cantabria, Hosp Univ Marques de Valdecilla, Infect Dis Unit, Santander, Spain.
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Kazak, EsraUludag Univ, Bursa, Turkey.
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Martinez-Martinez, LuisSpanish Network Res Infect Dis REIPI, Madrid, Spain.;Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Biomed Res Inst Cordoba IMIBIC, Dept Microbiol,Clin Unit Microbiol, Cordoba, Spain.
(author)
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Maria Aguado, JoseSpanish Network Res Infect Dis REIPI, Madrid, Spain.;Univ Complutense, Inst Invest Sanitaria Hosp 12 Octubre Imas12, Unit Infect Dis, 12 Octubre Univ Hosp, Madrid, Spain.
(author)
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Torre-Cisneros, JulianSpanish Network Res Infect Dis REIPI, Madrid, Spain.;Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Biomed Res Inst Cordoba IMIBIC, Clin Unit Infect Dis, Cordoba, Spain.
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Pascual, AlvaroSpanish Network Res Infect Dis REIPI, Madrid, Spain.;Univ Seville, Virgen Macarena Univ Hosp, Inst Biomed Seville, Clin Unit Infect Dis & Microbiol, Seville, Spain.
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Rodriguez-Bano, JesusSpanish Network Res Infect Dis REIPI, Madrid, Spain.;Univ Seville, Virgen Macarena Univ Hosp, Inst Biomed Seville, Clin Unit Infect Dis & Microbiol, Seville, Spain.
(author)
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Spanish Network Res Infect Dis REIPI, Madrid, Spain.;Univ Seville, Virgen Macarena Univ Hosp, Inst Biomed Seville, Clin Unit Infect Dis & Microbiol, Seville, Spain.Spanish Network Res Infect Dis REIPI, Madrid, Spain.;Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Biomed Res Inst Cordoba IMIBIC, Cordoba, Spain.
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In:Antimicrobial Agents and Chemotherapy: American Society for Microbiology65:110066-48041098-6596
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Perez-Nadales, E ...
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Carratala, Jordi
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Oriol, Isabel
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Cordero, Elisa
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