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Impact of depth of ...
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Percival, Mary-ElizabethUniv Washington, Div Hematol, Seattle, WA 98195 USA.;Univ Washington, Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98195 USA.
(author)
Impact of depth of clinical response on outcomes of acute myeloid leukemia patients in first complete remission who undergo allogeneic hematopoietic cell transplantation
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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2021-04-16
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Springer Nature,2021
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-470114
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-470114URI
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https://doi.org/10.1038/s41409-021-01261-6DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:146401614URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Acute myeloid leukemia (AML) patients often undergo allogeneic hematopoietic cell transplantation (alloHCT) in first complete remission (CR). We examined the effect of depth of clinical response, including incomplete count recovery (CRi) and/or measurable residual disease (MRD), in patients from the Center for International Blood and Marrow Transplantation Research (CIBMTR) registry. We identified 2492 adult patients (1799 CR and 693 CRi) who underwent alloHCT between January 1, 2007 and December 31, 2015. The primary outcome was overall survival (OS). Multivariable analysis was performed to adjust for patient-, disease-, and transplant-related factors. Baseline characteristics were similar. Patients in CRi compared to those in CR had an increased likelihood of death (HR: 1.27; 95% confidence interval: 1.13-1.43). Compared to CR, CRi was significantly associated with increased non-relapse mortality (NRM), shorter disease-free survival (DFS), and a trend toward increased relapse. Detectable MRD was associated with shorter OS, shorter DFS, higher NRM, and increased relapse compared to absence of MRD. The deleterious effects of CRi and MRD were independent. In this large CIBMTR cohort, survival outcomes differ among AML patients based on depth of CR and presence of MRD at the time of alloHCT. Further studies should focus on optimizing post-alloHCT outcomes for patients with responses less than CR.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Wang, Hai-LinMed Coll Wisconsin, Dept Med, CIBMTR Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.
(author)
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Zhang, Mei-JieMed Coll Wisconsin, Dept Med, CIBMTR Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Div Biostat, Inst Hlth & Equ, Milwaukee, WI 53226 USA.
(author)
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Saber, WaelMed Coll Wisconsin, Dept Med, CIBMTR Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.
(author)
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de Lima, MarcosUniv Hosp Case Med Ctr, Seidman Canc Ctr, Dept Med, Cleveland, OH USA.
(author)
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Litzow, MarkMayo Clin Rochester, Div Hematol, Rochester, MN USA.;Mayo Clin Rochester, Transplant Ctr, Rochester, MN USA.
(author)
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Kebriaei, PartowUniv Texas MD Anderson Canc Ctr, Dept Stem Cell Transplantat, Div Canc Med, Houston, TX 77030 USA.
(author)
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Abdel-Azim, HishamUniv Southern Calif, Div Hematol Oncol & Blood & Marrow Transplantat, Childrens Hosp Los Angeles, Keck Sch Med, Los Angeles, CA 90007 USA.
(author)
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Adekola, KehindeNorthwestern Univ, Dept Med, Div Hematol & Oncol, Chicago, IL 60611 USA.;Northwestern Univ, Feinberg Sch Med, Robert H Lurie Comprehens Canc, Chicago, IL 60611 USA.
(author)
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Aljurf, MahmoudKing Faisal Specialist Hosp Ctr & Res, Dept Oncol, Riyadh, Saudi Arabia.
(author)
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Bacher, UlrikeUniv Bern, Bern Univ Hosp, Inselspital, Dept Hematol, Bern, Switzerland.
(author)
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Badawy, Sherif M.Ann & Robert H Lurie Childrens Hosp Chicago, Div Hematol Oncol & Stem Cell Transplant, Chicago, IL 60611 USA.;Northwestern Univ, Dept Pediat, Feinberg Sch Med, Chicago, IL 60611 USA.
(author)
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Beitinjaneh, AmerUniv Miami, Miami, FL USA.
(author)
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Bejanyan, NelliH Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplant & Cellular Immunot, Tampa, FL USA.
(author)
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Bhatt, VijayaUniv Nebraska Med Ctr, Fred & Pamela Buffett Canc Ctr, Omaha, NE USA.
(author)
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Byrne, MichaelVanderbilt Univ, Med Ctr, Nashville, TN USA.
(author)
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Cahn, Jean-YvesCHU Grenoble Alpes, Dept Hematol, Grenoble, France.
(author)
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Castillo, PaulUF Hlth Shands Childrens Hosp, Gainesville, FL USA.
(author)
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Chao, NelsonDuke Univ, Dept Med, Div Cell Therapy & Hematol, Med Ctr, Durham, NC USA.
(author)
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Chhabra, SaurabhMed Coll Wisconsin, Dept Med, CIBMTR Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Dept Med, Div Hematol & Oncol, Milwaukee, WI 53226 USA.
(author)
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Copelan, EdwardAtrium Hlth, Levine Canc Inst, Dept Hematol Oncol & Blood Disorders, Charlotte, NC USA.
(author)
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Cutler, CoreyDana Farber Canc Inst, Ctr Hematol Oncol, Boston, MA 02115 USA.
(author)
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DeFilipp, ZachariahMassachusetts Gen Hosp, Blood & Marrow Transplant Program, Boston, MA USA.
(author)
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Dias, AjoyBeth Israel Deaconess Med Ctr, Westwood, KS USA.
(author)
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Diaz, Miguel AngelHosp Infantil Univ Nino Jesus, Dept Hematol Oncol, Madrid, Spain.
(author)
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Estey, ElihuUniv Washington, Div Hematol, Seattle, WA 98195 USA.;Univ Washington, Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98195 USA.
(author)
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Farhadfar, NoshaUniv Florida, Coll Med, Div Hematol & Oncol, Gainesville, FL USA.
(author)
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Frangoul, Haydar A.Childrens Hosp, TriStar Centennial & Sarah Cannon Res Inst, Nashville, TN USA.
(author)
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Freytes, Cesar O.Texas Transplant Inst, San Antonio, TX USA.
(author)
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Gale, Robert PeterImperial Coll London, Dept Immunol & Inflammat, Haematol Res Ctr, London, England.;Mayo Clin, Div Hematol Oncol, Blood & Marrow Transplantat Program, Jacksonville, FL 32224 USA.
(author)
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Ganguly, SiddharthaUniv Kansas Hlth Syst, Div Hematol Malignancy & Cellular Therapeut, Kansas City, KS USA.
(author)
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Gowda, LohithYale New Haven Med Ctr, New Haven, CT USA.
(author)
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Grunwald, MichaelAtrium Hlth, Levine Canc Inst, Dept Hematol Oncol & Blood Disorders, Charlotte, NC USA.
(author)
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Hossain, NasheedLoyola Univ, Stritch Sch Med, Dept Med, Stem Cell Transplant Program,Div Hematol & Oncol, Maywood, IL 60153 USA.
(author)
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Kamble, Rammurti T.Baylor Coll Med, Ctr Cell & Gene Therapy, Div Hematol & Oncol, Houston, TX 77030 USA.
(author)
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Kanakry, Christopher G.NCI, Expt Transplantat & Immunol Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
(author)
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Kansagra, AnkitUT SouthWestern Med Ctr, BMT Program, Dallas, TX USA.
(author)
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Kharfan-Dabaja, Mohamed A.Mayo Clin, Div Hematol Oncol, Blood & Marrow Transplantat Program, Jacksonville, FL 32224 USA.
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Krem, MaxwellUniv Louisville Hosp, James Brown Canc Ctr, Louisville, KY USA.
(author)
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Lazarus, Hillard M.Case Western Reserve Univ, Univ Hosp Cleveland, Med Ctr, Cleveland, OH 44106 USA.
(author)
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Lee, Jong WookCatholic Univ Korea, Seoul St Marys Hosp, Div Hematol, Seoul, South Korea.
(author)
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Liesveld, Jane L.Univ Rochester, Med Ctr, Dept Med, Rochester, NY 14642 USA.
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Lin, RichardMem Sloan Kettering Canc Ctr Adults, New York, NY USA.
(author)
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Liu, HongtaoUniv Chicago Med, Chicago, IL USA.
(author)
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McGuirk, JosephUniv Kansas, Westwood, KS USA.
(author)
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Munker, ReinholdUniv Kentucky, Markey Canc Ctr, Lexington, KY USA.
(author)
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Murthy, Hemant S.Mayo Clin, Div Hematol Oncol, Blood & Marrow Transplantat Program, Jacksonville, FL 32224 USA.,Dokkyo Med Univ, Dept Hematol & Oncol, Mibu, Tochigi, Japan.
(author)
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Nathan, SunitaRush Univ, Med Ctr, Chicago, IL 60612 USA.
(author)
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Nishihori, TaigaH Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplant & Cellular Immunot, Tampa, FL USA.
(author)
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Olsson, RichardUppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Inst, Dept Lab Med, Stockholm, Sweden.(Swepub:uu)riols677
(author)
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Palmisiano, NeilThomas Jefferson Univ, Sidney Kimmel Canc Ctr, Philadelphia, PA 19107 USA.
(author)
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Passweg, Jakob R.Univ Hosp Basel, Basel, Switzerland.
(author)
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Prestidge, TimStarship Childrens Hosp, Blood & Canc Ctr, Auckland, New Zealand.
(author)
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Ringden, OlovKarolinska Institutet,Karolinska Inst, CLINTEC Clin Sci Intervent & Technol, Translat Cell Therapy Grp, Stockholm, Sweden.
(author)
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Rizzieri, David A.Duke Univ, Div Hematol Malignancies & Cellular Therapy, Durham, NC USA.
(author)
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Rybka, Witold B.Penn State Hershey Med Ctr, Hershey, PA USA.
(author)
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Savoie, Mary LynnTom Baker Canc Clin, Calgary, AB, Canada.
(author)
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Schultz, Kirk R.Univ British Columbia, British Columbias Childrens Hosp, Dept Pediat Hematol Oncol & Bone Marrow Transplan, Vancouver, BC, Canada.
(author)
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Seo, SachikoDokkyo Med Univ, Dept Hematol & Oncol, Mibu, Tochigi, Japan.
(author)
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Sharma, AkshaySt Jude Childrens Res Hosp, Dept Bone Marrow Transplantat & Cellular Therapy, 332 N Lauderdale St, Memphis, TN 38105 USA.
(author)
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Solh, MelhemNorthside Hosp, Blood & Marrow Transplant Grp Georgia, Atlanta, GA USA.
(author)
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Strair, RogerRutgers State Univ, Rutgers Canc Inst New Jersey, New Brunswick, NJ USA.
(author)
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van der Poel, MarjoleinMaastricht Univ, Med Ctr, Maastricht, Netherlands.
(author)
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Verdonck, Leo F.Isala Clin, Dept Hematol Oncol, Zwolle, Netherlands.
(author)
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Yared, Jean A.Univ Maryland, Dept Med, Greenebaum Comprehens Canc Ctr, Div Hematol & Oncol,Blood & Marrow Transplantat P, Baltimore, MD 21201 USA.
(author)
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Weisdorf, DanielUniv Minnesota, Dept Med, Div Hematol Oncol & Transplantat, Box 736 UMHC, Minneapolis, MN 55455 USA.;Natl Marrow Donor Program Be Match, CIBMTR Ctr Int Blood & Marrow Transplant Res, Minneapolis, MN USA.
(author)
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Sandmaier, Brenda M.Univ Washington, Div Med Oncol, Seattle, WA 98195 USA.;Fred Hutchinson Canc Res Ctr, Div Clin Res, 1124 Columbia St, Seattle, WA 98104 USA.
(author)
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Univ Washington, Div Hematol, Seattle, WA 98195 USA.;Univ Washington, Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98195 USA.Med Coll Wisconsin, Dept Med, CIBMTR Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.
(creator_code:org_t)
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In:Bone Marrow Transplantation: Springer Nature56:9, s. 2108-21170268-33691476-5365
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Percival, Mary-E ...
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Wang, Hai-Lin
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Zhang, Mei-Jie
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Saber, Wael
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de Lima, Marcos
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Litzow, Mark
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Kebriaei, Partow
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Abdel-Azim, Hish ...
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Adekola, Kehinde
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Aljurf, Mahmoud
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Bacher, Ulrike
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Badawy, Sherif M ...
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Beitinjaneh, Ame ...
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Bejanyan, Nelli
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Bhatt, Vijaya
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Byrne, Michael
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Cahn, Jean-Yves
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Castillo, Paul
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Chao, Nelson
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Chhabra, Saurabh
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Copelan, Edward
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Cutler, Corey
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DeFilipp, Zachar ...
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Dias, Ajoy
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Diaz, Miguel Ang ...
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Estey, Elihu
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Farhadfar, Nosha
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Frangoul, Haydar ...
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Freytes, Cesar O ...
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Gale, Robert Pet ...
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Ganguly, Siddhar ...
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Gowda, Lohith
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Grunwald, Michae ...
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Hossain, Nasheed
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Kamble, Rammurti ...
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Kanakry, Christo ...
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Kansagra, Ankit
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Kharfan-Dabaja, ...
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Krem, Maxwell
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Lazarus, Hillard ...
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Lee, Jong Wook
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Liesveld, Jane L ...
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Lin, Richard
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Liu, Hongtao
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McGuirk, Joseph
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Munker, Reinhold
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Murthy, Hemant S ...
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Nathan, Sunita
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Nishihori, Taiga
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Olsson, Richard
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Palmisiano, Neil
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Passweg, Jakob R ...
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Prestidge, Tim
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Ringden, Olov
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Rizzieri, David ...
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Rybka, Witold B.
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Savoie, Mary Lyn ...
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Schultz, Kirk R.
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Seo, Sachiko
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Sharma, Akshay
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Solh, Melhem
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Strair, Roger
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van der Poel, Ma ...
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Verdonck, Leo F.
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Yared, Jean A.
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Weisdorf, Daniel
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Sandmaier, Brend ...
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Karolinska Institutet