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Decreased renal per...
Decreased renal perfusion during acute kidney injury in critical COVID-19 assessed by magnetic resonance imaging : a prospective case control study
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- Luther, Tomas (författare)
- Uppsala universitet,Anestesiologi och intensivvård
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- Eckerbom, Per, 1974- (författare)
- Uppsala universitet,Radiologi
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- Cox, Eleanor (författare)
- Sir Peter Mansfield Imaging Centre, School of Physics & Astronomy, University of Nottingham, Nottingham, UK
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- Lipcsey, Miklós (författare)
- Uppsala universitet,Hedenstiernalaboratoriet
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- Bülow, Sara (författare)
- Uppsala universitet,Anestesiologi och intensivvård
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- Hultström, Michael, 1978- (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Anestesiologi och intensivvård
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- Martinez Torrente, Francisco (författare)
- Uppsala universitet,Anestesiologi och intensivvård
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- Weis, Jan, 1956- (författare)
- Uppsala universitet,Radiologi
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- Palm, Fredrik, 1973- (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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- Francis, Susan (författare)
- Sir Peter Mansfield Imaging Centre, School of Physics & Astronomy, University of Nottingham, Nottingham, UK
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- Frithiof, Robert (författare)
- Uppsala universitet,Anestesiologi och intensivvård
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- Liss, Per, 1960- (författare)
- Uppsala universitet,Radiologi
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(creator_code:org_t)
- 2022-09-01
- 2022
- Engelska.
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Ingår i: Critical Care. - : Springer Nature. - 1364-8535 .- 1466-609X. ; 26
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Renal hypoperfusion has been suggested to contribute to the development of acute kidney injury (AKI) in critical COVID-19. However, limited data support this. In this prospective case-control study we aimed to investigate differences in renal perfusion, oxygenation and water diffusion using multiparametric magnetic resonance imaging (mpMRI) in critically ill COVID-19 patients with and without AKI. Nineteen patients without prior kidney disease treated in intensive care for respiratory failure were examined. Ten patients had AKI and nine patients did not have AKI using Kidney Disease: Improving Global Outcomes Creatinine criteria. Age and baseline Plasma-Creatinine were similar in both groups. Total renal blood flow was lower in patients with AKI compared with patients without (median 645 quartile range [423-753] vs. 859 [746-920] ml/min, P = 0.037). Regional perfusion was reduced in both cortex (76 [51-112] vs. 146 [123-169] mL/100g/min, P = 0.015) and medulla (28 [18-47] vs. 47 [38-73] mL/100g/min, P = 0.03). Renal venous saturation was similar in both groups (72% [64-75] vs. 72% [63-84], ns.), as was regional oxygenation (R2*) in cortex (17 [16-19] vs. 17 [16-18] 1/s, ns.) and medulla (29 [24-39] vs. 27 [23-29] 1/s, ns.). We conclude that in critically ill COVID-19 patients with AKI, the total, cortical and medullary renal blood flow are reduced compared with similar patients without AKI, whereas no differences in renal oxygenation were demonstrable in this setting.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Luther, Tomas
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Eckerbom, Per, 1 ...
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Cox, Eleanor
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Lipcsey, Miklós
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Bülow, Sara
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Hultström, Micha ...
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visa fler...
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Martinez Torrent ...
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Weis, Jan, 1956-
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Palm, Fredrik, 1 ...
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Francis, Susan
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Frithiof, Robert
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Liss, Per, 1960-
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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Critical Care
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Uppsala universitet