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Effectiveness of Wr...
Effectiveness of Written Dietary Advice for Improving Blood Lipids in Primary Care Adults-A Pragmatic Randomized Controlled Trial (MYDICLIN)
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- Rydell, Andreas (author)
- Karolinska Institutet,Uppsala universitet,Centrum för klinisk forskning Dalarna,Norslund Svardsjo Acad Primary Hlth Care Ctr, Svardsjo Vardcentral Bjorkvagen 2, S-79023 Svardsjo, Sweden.;Karolinska Inst, Div Family Med & Primary Care, Dept Neurobiol Care Sci & Soc, Alfred Nobels 23, S-14183 Huddinge, Sweden.
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- Hellsten, Mikael (author)
- Norslund Svardsjo Acad Primary Hlth Care Ctr, Svardsjo Vardcentral Bjorkvagen 2, S-79023 Svardsjo, Sweden.
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- Lindow, Martin (author)
- Örebro Univ, Sch Med Sci, Campus USO, S-70182 Örebro, Sweden.
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- Iggman, David (author)
- Uppsala universitet,Klinisk nutrition och metabolism,Centrum för klinisk forskning Dalarna,Norslund Svardsjo Acad Primary Hlth Care Ctr, Svardsjo Vardcentral Bjorkvagen 2, S-79023 Svardsjo, Sweden.
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(creator_code:org_t)
- 2022-02-28
- 2022
- English.
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In: Nutrients. - : MDPI AG. - 2072-6643. ; 14:5
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Abstract
Subject headings
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- Lifestyle management is the first line of treatment for moderately elevated blood lipids in healthy individuals. We investigated the effectiveness of providing food-based written advice for lowering low-density lipoprotein (LDL) cholesterol (intervention) or triglycerides (control) in a pragmatic randomized controlled trial with two parallel arms from 2018-2019 at a rural primary health care center. We sent feedback letters after 3 weeks and 6 months. Out of the 113 adult primary care patients randomized, 112 completed the study. There were no differences between the intervention and control groups for changes in LDL cholesterol after 3 weeks (mean +/- standard deviation -0.21 +/- 0.38 vs. -0.11 +/- 0.34 mmol/L, p = 0.45) or 6 months (-0.05 +/- 0.47 vs. 0.02 +/- 0.41 mmol/L, p = 0.70) (primary outcome). Following the advice to consume plant sterols and turmeric was associated with a reduction in LDL cholesterol after 3 weeks. Following the advice to consume less carbohydrates was associated with reduced triglycerides. In the intervention arm, 14 individuals (25%) reduced their LDL cholesterol by >= 10% after three weeks. Their reduction was attenuated but maintained after six months (-7.1 +/- 9.2% or -0.31 +/- 0.38 mmol/L, p = 0.01 compared with baseline). They differed only in higher adherence to the advice regarding turmeric. In conclusion, this undemanding intervention had little effect on blood lipids for most individuals.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- LDL cholesterol
- triglycerides
- lipids
- primary care
- foods
- dietary advice
Publication and Content Type
- ref (subject category)
- art (subject category)
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