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Indoor microbiome, ...
Indoor microbiome, air pollutants and asthma, rhinitis and eczema in preschool children - A repeated cross-sectional study
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- Sun, Yu (author)
- Shanxi Univ, Inst Environm Sci, Taiyuan, Peoples R China.;South China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr O, Guangzhou 510642, Guangdong, Peoples R China.;Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Key Lab Zoonosis, Minist Agr & Rural Affairs, Guangzhou 510642, Guangdong, Peoples R China.
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- Meng, Yi (author)
- South China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr O, Guangzhou 510642, Guangdong, Peoples R China.;Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Key Lab Zoonosis, Minist Agr & Rural Affairs, Guangzhou 510642, Guangdong, Peoples R China.
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- Ou, Zheyuan (author)
- South China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr O, Guangzhou 510642, Guangdong, Peoples R China.;Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Key Lab Zoonosis, Minist Agr & Rural Affairs, Guangzhou 510642, Guangdong, Peoples R China.
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- Li, Yanling (author)
- South China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr O, Guangzhou 510642, Guangdong, Peoples R China.;Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Key Lab Zoonosis, Minist Agr & Rural Affairs, Guangzhou 510642, Guangdong, Peoples R China.
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- Zhang, Mei (author)
- South China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr O, Guangzhou 510642, Guangdong, Peoples R China.;Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Key Lab Zoonosis, Minist Agr & Rural Affairs, Guangzhou 510642, Guangdong, Peoples R China.
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- Chen, Yang (author)
- South China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr O, Guangzhou 510642, Guangdong, Peoples R China.;Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Key Lab Zoonosis, Minist Agr & Rural Affairs, Guangzhou 510642, Guangdong, Peoples R China.
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- Zhang, Zefei (author)
- Shanxi Univ, Inst Environm Sci, Taiyuan, Peoples R China.
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- Chen, Xingyi (author)
- Shanxi Univ, Inst Environm Sci, Taiyuan, Peoples R China.
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- Mu, Peiqiang (author)
- South China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr O, Guangzhou 510642, Guangdong, Peoples R China.;Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Key Lab Zoonosis, Minist Agr & Rural Affairs, Guangzhou 510642, Guangdong, Peoples R China.
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- Norbäck, Dan (author)
- Uppsala universitet,Arbets- och miljömedicin
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- Zhao, Zhuohui (author)
- Fudan Univ, Dept Environm Hlth, Sch Publ Hlth,Shanghai Typhoon Inst CMA,Shanghai, Key Lab Publ Hlth Safety,Minist Educ,NHC Key Lab, Shanghai 200030, Peoples R China.
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- Zhang, Xin (author)
- Shanxi Univ, Inst Environm Sci, Taiyuan, Peoples R China.
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- Fu, Xi (author)
- Guangdong Pharmaceut Univ, Sch Publ Hlth, Guangzhou 510006, Peoples R China.;Guangdong Pharmaceut Univ, Guangdong Prov Engn Res Ctr Publ Hlth Detect & As, Guangzhou, Peoples R China.
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Shanxi Univ, Inst Environm Sci, Taiyuan, Peoples R China;South China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr O, Guangzhou 510642, Guangdong, Peoples R China.;Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Key Lab Zoonosis, Minist Agr & Rural Affairs, Guangzhou 510642, Guangdong, Peoples R China. South China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr O, Guangzhou 510642, Guangdong, Peoples R China.;Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Key Lab Zoonosis, Minist Agr & Rural Affairs, Guangzhou 510642, Guangdong, Peoples R China. (creator_code:org_t)
- Elsevier, 2022
- 2022
- English.
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In: Environment International. - : Elsevier. - 0160-4120 .- 1873-6750. ; 161
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Abstract
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- Background: Indoor microbiome exposure is associated with asthma, rhinitis and eczema. However, no studies report the interactions between environmental characteristics, indoor microbiome and health effects in a repeated cross-sectional framework. Methods: 1,279 and 1,121 preschool children in an industrial city (Taiyuan) of China were assessed for asthma, rhinitis and eczema symptoms in 2012 and 2019 by self-administered questionnaires, respectively. Bacteria and fungi in classroom vacuum dust were characterized by culture-independent amplicon sequencing. Multi-level logistic/linear regression was performed in two cross-sectional and two combined models to assess the associations. Results: The number of observed species in bacterial and fungal communities in classrooms increased significantly from 2012 to 2019, and the compositions of the microbial communities were drastically changed (p < 0.001). The temporal microbiome variation was significantly larger than the spatial variation within the city (p < 0.001). Annual average outdoor SO2 concentration decreased by 60.7%, whereas NO2 and PM10 concentra-tions increased by 63.3% and 40.0% from 2012 to 2019, which were both associated with indoor microbiome variation (PERMANOVA p < 0.001). The prevalence of asthma (2.0% to 3.3%, p = 0.06) and rhinitis (28.0% to 25.3%, p = 0.13) were not significantly changed, but the prevalence of eczema was increased (3.6% to 7.0%; p < 0.001). Aspergillus subversicolor, Collinsella and Cutibacterium were positively associated with asthma, rhinitis and eczema, respectively (p < 0.01). Prevotella, Lactobacillus iners and Dolosigranulum were protectively (negatively) associated with rhinitis (p < 0.01), consistent with previous studies in the human respiratory tract. NO2 and PM10 concentrations were negatively associated with rhinitis in a bivariate model, but a multivariate mediation analysis revealed that Prevotella fully mediated the health effects. Conclusions: This is the first study to report the interactions between environmental characteristics, indoor microbiome and health in a repeated cross-sectional framework. The mediating effects of indoor microorganisms suggest incorporating biological with chemical exposure for a comprehensive exposure assessment.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- Amplicon sequencing
- Repeated cross-sectional study
- Microbial diversity and community variation
- Asthma
- Rhinitis
- Eczema
- Preschool children
- Air pollutants
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Sun, Yu
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Meng, Yi
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Ou, Zheyuan
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Li, Yanling
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Zhang, Mei
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Chen, Yang
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Zhang, Zefei
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Chen, Xingyi
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Mu, Peiqiang
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Norbäck, Dan
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Zhao, Zhuohui
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Zhang, Xin
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Fu, Xi
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- MEDICAL AND HEALTH SCIENCES
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and Respiratory Medi ...
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Environment Inte ...
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Uppsala University