SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Cong J)
 

Search: WFRF:(Cong J) > (2020-2024) > Cerebrolysin restor...

  • Sharma, Hari ShankerUppsala universitet,Anestesiologi och intensivvård (author)

Cerebrolysin restores balance between excitatory and inhibitory amino acids in brain following concussive head injury : Superior neuroprotective effects of TiO2 nanowired drug delivery

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • Elsevier BV,2021
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-468961
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-468961URI
  • https://doi.org/10.1016/bs.pbr.2021.06.016DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:kap swepub-publicationtype

Notes

  • Concussive head injury (CHI) often associated with military personnel, soccer players and related sports personnel leads to serious clinical situation causing lifetime disabilities. About 3-4 k head injury per 100 k populations are recorded in the United States since 2000-2014. The annual incidence of concussion has now reached to 1.2% of population in recent years. Thus, CHI inflicts a huge financial burden on the society for rehabilitation. Thus, new efforts are needed to explore novel therapeutic strategies to treat CHI cases to enhance quality of life of the victims. CHI is well known to alter endogenous balance of excitatory and inhibitory amino acid neurotransmitters in the central nervous system (CNS) leading to brain pathology. Thus, a possibility exists that restoring the balance of amino acids in the CNS following CHI using therapeutic measures may benefit the victims in improving their quality of life. In this investigation, we used a multimodal drug Cerebrolysin (Ever NeuroPharma, Austria) that is a well-balanced composition of several neurotrophic factors and active peptide fragments in exploring its effects on CHI induced alterations in key excitatory (Glutamate, Aspartate) and inhibitory (GABA, Glycine) amino acids in the CNS in relation brain pathology in dose and time-dependent manner. CHI was produced in anesthetized rats by dropping a weight of 114.6 g over the right exposed parietal skull from a distance of 20 cm height (0.224 N impact) and blood-brain barrier (BBB), brain edema, neuronal injuries and behavioral dysfunctions were measured 8, 24, 48 and 72 h after injury. Cerebrolysin (CBL) was administered (2.5, 5 or 10 mL/kg, i.v.) after 4-72 h following injury. Our observations show that repeated CBL induced a dose-dependent neuroprotection in CHI (5-10 mL/kg) and also improved behavioral functions. Interestingly when CBL is delivered through TiO2 nanowires superior neuroprotective effects were observed in CHI even at a lower doses (2.5-5 mL/kg). These observations are the first to demonstrate that CBL is effectively capable to attenuate CHI induced brain pathology and behavioral disturbances in a dose dependent manner, not reported earlier.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Muresanu, Dafin F.Univ Med & Pharm, Dept Clin Neurosci, Cluj Napoca, Romania.;RoNeuro Inst Neurol Res & Diagnost, Cluj Napoca, Romania. (author)
  • Sahib, SeaabUniv Arkansas, Dept Chem & Biochem, Fayetteville, AR 72701 USA. (author)
  • Tian, Z. RyanUniv Arkansas, Dept Chem & Biochem, Fayetteville, AR 72701 USA. (author)
  • Vicente Lafuente, JoseUniv Basque Country, UPV EHU, Dept Neurosci, LaNCE, Leioa, Bizkaia, Spain. (author)
  • Buzoianu, Anca D.Iuliu Hatieganu Univ Med & Pharm, Dept Clin Pharmacol & Toxicol, Cluj Napoca, Romania. (author)
  • Castellani, Rudy J.Univ Maryland, Dept Pathol, Baltimore, MD 21201 USA. (author)
  • Nozari, AlaMassachusetts Gen Hosp, Anesthesiol & Intens Care, Boston, MA 02114 USA. (author)
  • Li, CongChinese Med Hosp Guangdong Prov, Dept Neurosurg, Guangzhou, Peoples R China.;Guangzhou Univ Chinese Med, Affiliated Hosp 2, Guangzhou, Peoples R China. (author)
  • Zhang, ZhiquiangChinese Med Hosp Guangdong Prov, Dept Neurosurg, Guangzhou, Peoples R China.;Guangzhou Univ Chinese Med, Affiliated Hosp 2, Guangzhou, Peoples R China. (author)
  • Wiklund, LarsUppsala universitet,Anestesiologi och intensivvård(Swepub:uu)larswikl (author)
  • Sharma, ArunaUppsala universitet,Anestesiologi och intensivvård(Swepub:uu)arush975 (author)
  • Uppsala universitetAnestesiologi och intensivvård (creator_code:org_t)

Related titles

  • In:Brain protection strategies and nanomedicine: Elsevier BV, s. 211-2679780323989275

Internet link

Find in a library

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view