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Obstructive sleep a...
Obstructive sleep apnea is an independent risk factor for severe COVID-19 : a population-based study
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- Rögnvaldsson, Kristjan Godsk (författare)
- Univ Iceland, Fac Med, Sturlugata 8, IS-101 Reykjavik, Iceland.
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- Eythorsson, Elias Saebjörn (författare)
- Natl Univ Hosp Iceland, Internal Med & Emergency Serv, Landspitali, Reykjavik, Iceland.
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- Emilsson, Össur Ingi (författare)
- Uppsala universitet,Lung- allergi- och sömnforskning,Univ Iceland, Fac Med, Sturlugata 8, IS-101 Reykjavik, Iceland.
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- Eysteinsdottir, Björg (författare)
- Natl Univ Hosp Iceland, Div Resp Med & Sleep, Landspitali, Reykjavik, Iceland.
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- Palsson, Runolfur (författare)
- Univ Iceland, Fac Med, Sturlugata 8, IS-101 Reykjavik, Iceland.;Natl Univ Hosp Iceland, Internal Med & Emergency Serv, Landspitali, Reykjavik, Iceland.
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- Gottfredsson, Magnus (författare)
- Univ Iceland, Fac Med, Sturlugata 8, IS-101 Reykjavik, Iceland.;Natl Univ Hosp Iceland, Div Infect Dis, Landspitali, Reykjavik, Iceland.
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- Gudmundsson, Gunnar (författare)
- Univ Iceland, Fac Med, Sturlugata 8, IS-101 Reykjavik, Iceland.;Natl Univ Hosp Iceland, Div Resp Med & Sleep, Landspitali, Reykjavik, Iceland.
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- Steingrimsson, Vilhjalmur (författare)
- Univ Iceland, Fac Med, Sturlugata 8, IS-101 Reykjavik, Iceland.;Natl Univ Hosp Iceland, Internal Med & Emergency Serv, Landspitali, Reykjavik, Iceland.
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Univ Iceland, Fac Med, Sturlugata 8, IS-101 Reykjavik, Iceland Natl Univ Hosp Iceland, Internal Med & Emergency Serv, Landspitali, Reykjavik, Iceland. (creator_code:org_t)
- 2021-11-17
- 2022
- Engelska.
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Ingår i: Sleep. - : Oxford University Press (OUP). - 0161-8105 .- 1550-9109. ; 45:3
- Relaterad länk:
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Study Objectives Obstructive sleep apnea (OSA) has been proposed as a risk factor for severe COVID-19. Confounding is an important consideration as OSA is associated with several known risk factors for severe COVID-19. Our aim was to assess the association of OSA with hospitalization due to COVID-19 using a population-based cohort with detailed information on OSA and comorbidities. Methods Included were all community-dwelling Icelandic citizens 18 years of age and older diagnosed with SARS-CoV-2 infection in 2020. Data on demographics, comorbidities, and outcomes of COVID-19 was obtained from centralized national registries. Diagnosis of OSA was retrieved from the centralized Sleep Department Registry at Landspitali - The National University Hospital. Severe COVID-19 was defined as the composite outcome of hospitalization and death. The associations between OSA and the outcome were expressed as odds ratios (OR) with 95% confidence intervals (95% CI), calculated using logistic regression models and inverse probability weighting. Results A total of 4,756 individuals diagnosed with SARS-CoV-2 infection in Iceland were included in the study (1.3% of the Icelandic population), of whom 185 had a diagnosis of OSA. In total, 238 were hospitalized or died, 38 of whom had OSA. Adjusted for age, sex, and BMI, OSA was associated with poor outcome (OR 2.2, 95% CI 1.4-3.5). This association was slightly attenuated (OR 2.0, 95% CI 2.0, 1.2-3.2) when adjusted for demographic characteristics and various comorbidities. Conclusions OSA was associated with twofold increase in risk of severe COVID-19, and the association was not explained by obesity or other comorbidities.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Nyckelord
- COVID-19
- comorbidities
- hospitalization
- obstructive sleep apnea
- positive airway pressure treatment
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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