Sökning: WFRF:(Sapisochin Gonzalo) >
Dynamic risk profil...
Dynamic risk profiling of HCC recurrence after curative intent liver resection
-
- Ivanics, Tommy (författare)
- Uppsala universitet,Gastrointestinalkirurgi,Multi‐Organ Transplant Program University Health Network Toronto Toronto Ontario Canada;Department of Surgery Henry Ford Hospital Detroit Michigan USA.
-
- Murillo Perez, Carla Fiorella (författare)
- Multi‐Organ Transplant Program University Health Network Toronto Toronto Ontario Canada;Toronto Centre for Liver Disease Toronto Western & General Hospital University Health Network Toronto Ontario Canada
-
- Claasen, Marco P. A. W. (författare)
- Multi‐Organ Transplant Program University Health Network Toronto Toronto Ontario Canada;Department of Surgery Erasmus MC University Medical Centre Rotterdam Rotterdam the Netherlands
-
visa fler...
-
- Patel, Madhukar S. (författare)
- Multi‐Organ Transplant Program University Health Network Toronto Toronto Ontario Canada;Division of Surgical Transplantation, Department of Surgery University of Texas Southwestern Medical Center Dallas Texas USA
-
- Morgenshtern, Gabriela (författare)
- Department of Computer Science University of Toronto Toronto Ontario Canada
-
- Erdman, Lauren (författare)
- Department of Computer Science University of Toronto Toronto Ontario Canada
-
- Shwaartz, Chaya (författare)
- Multi‐Organ Transplant Program University Health Network Toronto Toronto Ontario Canada;Division of General Surgery University of Toronto Toronto Ontario Canada
-
- Rajendran, Luckshi (författare)
- Division of General Surgery University of Toronto Toronto Ontario Canada
-
- O’Kane, Grainne M. (författare)
- Department of Medical Oncology and Hematology Princess Margaret Cancer Centre University Health Network Toronto Ontario Canada
-
- Hansen, Bettina E. (författare)
- Toronto Centre for Liver Disease Toronto Western & General Hospital University Health Network Toronto Ontario Canada;Institute of Health Policy, Management and Evaluation University of Toronto Toronto Ontario Canada
-
- Cleary, Sean P (författare)
- Division of Hepatobiliary and Pancreatic Surgery Mayo Clinic Rochester Minnesota USA
-
- Sapisochin, Gonzalo (författare)
- Multi‐Organ Transplant Program University Health Network Toronto Toronto Ontario Canada;Division of General Surgery University of Toronto Toronto Ontario Canada
-
visa färre...
-
(creator_code:org_t)
- 2022-03-02
- 2022
- Engelska.
-
Ingår i: Hepatology. - : Ovid Technologies (Wolters Kluwer Health). - 0270-9139 .- 1527-3350. ; 76:5, s. 1291-1301
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background and Aim: Following liver resection (LR) for HCC, the likelihood of survival is dynamic, in that multiple recurrences and/or metastases are possible, each having variable impacts on outcomes. We sought to evaluate the natural progression, pattern, and timing of various disease states after LR for HCC using multistate modeling and to create a practical calculator to provide prognostic information for patients and clinicians.Approach and Results: Adult patients undergoing LR for HCC between January 2000 and December 2018 were retrospectively identified at a single center. Multistate analysis modeled post-LR tumor progression by describing transitions between distinct disease states. In this model, the states included surgery, intrahepatic recurrence (first, second, third, fourth, fifth), distant metastasis with or without intrahepatic recurrence, and death. Of the 486 patients included, 169 (34.8%) remained recurrence-free, 205 (42.2%) developed intrahepatic recurrence, 80 (16.5%) developed distant metastasis, and 32 (7%) died. For an average patient having undergone LR, there was a 33.1% chance of remaining disease-free, a 31.0% chance of at least one intrahepatic recurrence, a 16.3% chance of distant metastasis, and a 19.8% chance of death within the first 60 months post-LR. The transition probability from surgery to first intrahepatic recurrence, without a subsequent state transition, increased from 3% (3 months) to 17.4% (30 months) and 17.2% (60 months). Factors that could modify these probabilities included tumor size, satellite lesions, and microvascular invasion. The online multistate model calculator can be found on https://multistatehcc.shinyapps.io/home/.Conclusions: In contrast to standard single time-to-event estimates, multistate modeling provides more realistic prognostication of outcomes after LR for HCC by taking into account many postoperative disease states and transitions between them. Our multistate modeling calculator can provide meaningful data to guide the management of patients undergoing postoperative surveillance and therapy.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Ivanics, Tommy
-
Murillo Perez, C ...
-
Claasen, Marco P ...
-
Patel, Madhukar ...
-
Morgenshtern, Ga ...
-
Erdman, Lauren
-
visa fler...
-
Shwaartz, Chaya
-
Rajendran, Lucks ...
-
O’Kane, Grainne ...
-
Hansen, Bettina ...
-
Cleary, Sean P
-
Sapisochin, Gonz ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Kirurgi
- Artiklar i publikationen
-
Hepatology
- Av lärosätet
-
Uppsala universitet