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Temporal distributi...
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Dahal, PrabinWorld Wide Antimalarial Resistance Network WWARN, Oxford, England.;Infect Dis Data Observ IDDO, Oxford, England.;Univ Oxford, Ctr Trop Med & Global Hlth, Nuffield Dept Med, Oxford, England.
(author)
Temporal distribution of Plasmodium falciparum recrudescence following artemisinin-based combination therapy : an individual participant data meta-analysis
- Article/chapterEnglish2022
Publisher, publication year, extent ...
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2022-03-24
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Springer Nature,2022
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-472404
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-472404URI
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https://doi.org/10.1186/s12936-021-03980-zDOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:149135963URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Background: The duration of trial follow-up affects the ability to detect recrudescent infections following anti-malarial treatment. The aim of this study was to explore the proportions of recrudescent parasitaemia as ascribed by genotyping captured at various follow-up time-points in treatment efficacy trials for uncomplicated Plasmodium falciparum malaria.Methods: Individual patient data from 83 anti-malarial efficacy studies collated in the WorldWide Antimalarial Resistance Network (WWARN) repository with at least 28 days follow-up were available. The temporal and cumulative distributions of recrudescence were characterized using a Cox regression model with shared frailty on study-sites. Fractional polynomials were used to capture non-linear instantaneous hazard. The area under the density curve (AUC) of the constructed distribution was used to estimate the optimal follow-up period for capturing a P. falciparum malaria recrudescence. Simulation studies were conducted based on the constructed distributions to quantify the absolute overestimation in efficacy due to sub-optimal follow-up.Results: Overall, 3703 recurrent infections were detected in 60 studies conducted in Africa (15,512 children aged < 5 years) and 23 studies conducted in Asia and South America (5272 patients of all ages). Using molecular genotyping, 519 (14.0%) recurrences were ascribed as recrudescent infections. A 28 day artemether-lumefantrine (AL) efficacy trial would not have detected 58% [95% confidence interval (CI) 47-74%] of recrudescences in African children and 32% [95% CI 15-45%] in patients of all ages in Asia/South America. The corresponding estimate following a 42 day dihydroartemisinin-piperaquine (DP) efficacy trial in Africa was 47% [95% CI 19-90%] in children under 5 years old treated with > 48 mg/kg total piperaquine (PIP) dose and 9% [95% CI 0-22%] in those treated with <= 48 mg/kg PIP dose. In absolute terms, the simulation study found that trials limited to 28 days follow-up following AL underestimated the risk of recrudescence by a median of 2.8 percentage points compared to day 63 estimates and those limited to 42 days following DP underestimated the risk of recrudescence by a median of 2.0 percentage points compared to day 42 estimates. The analysis was limited by few clinical trials following patients for longer than 42 days (9 out of 83 trials) and the imprecision of PCR genotyping which overcalls recrudescence in areas of higher transmission biasing the later distribution.Conclusions: Restricting follow-up of clinical efficacy trials to day 28 for AL and day 42 for DP will miss a proportion of late recrudescent treatment failures but will have a modest impact in derived efficacy. The results highlight that as genotyping methods improve consideration should be given for trials with longer duration of follow-up to detect early indications of emerging drug resistance.
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Simpson, Julie AnneUniv Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia.
(author)
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Abdulla, SalimIfakara Hlth Inst, Dar Es Salaam, Tanzania.
(author)
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Achan, JaneMalaria Consortium, London, England.
(author)
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Adam, IshagUniv Khartoum, Fac Med, Khartoum, Sudan.
(author)
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Agarwal, AartiNew York City Dept Hlth & Mental Hyg, New York, NY USA.
(author)
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Allan, RichardMentor Initiat, Chicago, IL USA.
(author)
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Anvikar, Anupkumar R.Natl Inst Malaria Res, Sect 8, New Delhi 110077, Uganda.
(author)
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Ashley, Elizabeth A.Myanmar Oxford Clin Res Unit, Yangon, Myanmar.;Univ Oxford, Ctr Trop Med, Nuffield Dept Clin Med, Oxford, England.;Nangarhar Univ, Med Fac, Ghulam Rahim Awab, Afghanistan.;MORU Trop Hlth Network, Bangkok, Thailand.
(author)
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Bassat, QuiqueCtr Invest Manhica CISM, Maputo, Mozambique.;Univ Barcelona, ISGlobal, Hosp Clin, Barcelona, Spain.;ICREA, Pg Lluis Co 23, Barcelona 08010, Spain.;Consorcio Invest Biomed Red Epidemiol & Salud Pub, Madrid, Spain.;Karolinska Inst, Dept Microbiol Tumour & Cell Biol, Stockholm, Sweden.
(author)
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Borrmann, SteffenUniv Tubingen, Inst Trop Med, Tubingen, Germany.;Kenya Med Res Inst Wellcome Trust Res Programme, Kilifi, Kenya.;Heidelberg Univ, Dept Infect Dis, Sch Med, Heidelberg, Germany.
(author)
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Bousema, TeunRadboudumc Nijmegen, Radboud Inst Hlth Sci, Nijmegen, Netherlands.;Radboud Univ Nijmegen, Dept Med Microbiol, Med Ctr, Njimegen, Netherlands.
(author)
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Bukirwa, HasifaAfrican Field Epidemiol Network, Kampala, Uganda.
(author)
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Carrara, Verena, IShoklo Malaria Res Unit, Mae Sot, Thailand.;Mahidol Oxford Univ Res Unit, Bangkok, Thailand.
(author)
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Corsi, MarcoSigma Tau SpA Ind Farmaceut Riunite, Private Consultancy Drug Dev Trop Dis, Rome, Italy.;Univ Paris, MERIT, IRD, F-75006 Paris, France.
(author)
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D'Alessandro, UmbertoLondon Sch Hyg & Trop Med, Med Res Council Unit Gambia, Fajara, Gambia.;London Sch Hyg & Trop Med, London, England.
(author)
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Davis, Timothy M. E.Univ Western Australia, Med Sch, Crawley, WA, Australia.
(author)
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Deloron, PhilippeUniv Paris, MERIT, IRD 216, F-75006 Paris, France.
(author)
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Desai, MeghnaCtr Dis Control & Prevent, Div Parasit Dis & Malaria, Malaria Branch, Atlanta, GA USA.
(author)
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Dimbu, Pedro RafaelNatl Malaria Control Program, Luanda, Angola.
(author)
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Djalle, DjibrineInst Pasteur, BP 923, Bangui, Cent Afr Republ.
(author)
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Djimde, AbdoulayeUniv Sci Tech & Technol Bamako, Fac Pharm, Malaria Res & Training Ctr, Dept Epidemiol Parasit Dis, Bamako, Mali.
(author)
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Dorsey, GrantUniv Calif San Francisco, Dept Med, San Francisco, CA 94143 USA.
(author)
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Drakeley, Chris J.London Sch Hyg & Trop Med, Dept Infect Biol, London, England.
(author)
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Duparc, StephanMed Malaria Venture, Geneva, Switzerland.
(author)
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Edstein, Michael D.Australian Def Force Malaria & Infect Dis Inst, Brisbane, Qld, Australia.
(author)
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Espie, EmmanuelleGSK Vaccines, R&D Ctr, Clin & Epidemiol Dept, Ave Fleming 20, B-1300 Wavre, Belgium.;Epicentre, 8 Rue St Sabin, F-75011 Paris, France.
(author)
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Faiz, Abul
(author)
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Falade, CatherineUniv Ibadan, Coll Med, Dept Pharmacol & Therapeut, Ibadan, Nigeria.
(author)
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Fanello, CaterinaUniv Oxford, Ctr Global Hlth, Nuffield Dept Med, Oxford, England.
(author)
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Faucher, Jean-FrancoisINSERM, U1094, Trop Neuroepidemiol, Limoges, France.;Dept Infect Dis & Trop Med, F-87042 Limoges, France.
(author)
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Faye, BabacarUniv Cheikh Anta Diop, Dept Med Parasitol, Med Fac, Dakar, Senegal.
(author)
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Fortes, Filomeno de JesusUniv Nova Lisboa Portugal, Inst Hyg & Trop Med, Lisbon, Portugal.
(author)
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Gadalla, Nahla B.Sudanese Amer Med Assoc, Fairfax, VA USA.
(author)
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Gaye, OumarUniv Cheikh Anta Diop, Dept Med Parasitol, Med Fac, Dakar, Senegal.
(author)
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Gil, J. PedroKarolinska Institutet
(author)
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Gilayeneh, JuliusMinist Hlth, Natl Malaria Control Program, Monrovia, Liberia.
(author)
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Greenwood, BrianLondon Sch Hyg & Trop Med, Fac Infect & Trop Dis, London, England.
(author)
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Grivoyannis, AnastasiaJohns Hopkins Univ Hosp, Baltimore, MD 21287 USA.
(author)
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Hien, Tran TinhOxford Univ Clin Res Unit OUCRU, Ctr Trop Med, Wellcome Trust Major Overseas Program MOP, Oxford, England.
(author)
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Hwang, JimeeUS Ctr Dis Control & Prevent, US Presidents Malaria Initiat, Malaria Branch, Div Parasit Dis & Malaria, Atlanta, GA USA.;Univ Calif San Francisco, Global Hlth Grp, San Francisco, CA 94143 USA.
(author)
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Janssens, BartMed Sans Frontieres, Brussels, Belgium.
(author)
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Juma, ElizabethKenya Govt Med Res Ctr, Nairobi, Kenya.
(author)
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Kamugisha, ErasmusCatholic Univ Hlth & Allied Sci, Mwanza, Tanzania.
(author)
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Karema, CorineSwiss Trop & Publ Hlth Inst, Basel, Switzerland.;Univ Basel, Basel, Switzerland.
(author)
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Karunajeewa, Harin A.Univ Melbourne, Melbourne Med Sch, Western Hlth, Melbourne, Vic, Australia.;Sunshine Hosp, Western Hlth Chron Dis Alliance, Furlong Rd, St Albans, Vic 3021, Australia.
(author)
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Kiechel, Jean R.Drugs Neglected Dis Initiat, Geneva, Switzerland.
(author)
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Kironde, FredIslamic Univ Uganda, Fac Hlth Sci, Dept Microbiol, Mbale, Uganda.
(author)
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Kofoed, Poul-ErikIndepth Network, Bandim Hlth Project, Apartado 861, Bissau, Guinea Bissau.;Kolding Cty Hosp, Dept Paediat, Kolding, Denmark.;Univ Southern Denmark, IRS, Aarhus, Denmark.
(author)
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Kremsner, Peter G.Univ Tubingen, Inst Trop Med, Tubingen, Germany.;Ctr Rech Med Lambarene, Lambarene, Gabon.
(author)
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Lee, Sue J.Univ Oxford, Ctr Trop Med & Global Hlth, Nuffield Dept Med, Oxford, England.;Mahidol Univ, Fac Trop Med, Bangkok, Thailand.
(author)
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Marsh, KevinUniv Oxford, Ctr Trop Med, Nuffield Dept Clin Med, Oxford, England.;Kenya Med Res Inst Wellcome Trust Res Programme, Kilifi, Kenya.
(author)
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Mårtensson, Andreas,1963-Uppsala universitet,Internationell barnhälsa och nutrition(Swepub:uu)andma331
(author)
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Mayxay, MayfongMahosot Hosp, Lao Oxford Mahosot Hosp Wellcome Trust Res Unit, Microbiol Lab, Viangchan, Laos.;Churchill Hosp, Ctr Trop Med, Nuffield Dept Clin Med, Oxford, England.
(author)
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Menan, HerveUniv Cocody, Fac Pharm, Dept Parasitol, Abidjan, Cote Ivoire.
(author)
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Mens, PetraAmsterdam Univ Med Ctr, Parasitol, Med Microbiol, Amsterdam, Netherlands.
(author)
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Mutabingwa, Theonest K.Hubert Kairuki Mem Univ, Dar Es Salaam, Tanzania.;London Sch Hyg & Trop Med, Dept Infect & Trop Dis, London, England.
(author)
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Ndiaye, Jean-LouisUniv Thies, Dept Parasitol & Mycol, Hlth Sci Res & Training Unit, Thies, Senegal.
(author)
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Ngasala, BillyUppsala universitet,Internationell barnhälsa och nutrition,Muhimbili Univ Hlth & Allied Sci, Dept Parasitol, Dar Es Salaam, Tanzania.(Swepub:uu)bilng827
(author)
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Noedl, HaraldMalaria Res Initiat, Bandarban, Bangladesh.
(author)
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Nosten, FrancoisUniv Oxford, Ctr Trop Med & Global Hlth, Nuffield Dept Med Res Bldg,Old Rd Campus, Oxford, England.;Mahidol Univ, Fac Trop Med, Shoklo Malaria Res Unit, Mahidol Oxford Trop Med Res Unit, Mae Sot, Thailand.
(author)
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Offianan, Andre ToureInst Pasteur Cote Ivoire, Malariol Dept, Abidjan, Cote Ivoire.
(author)
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Ogutu, Bernhards R.Kenya Govt Med Res Ctr, US Army Med Res Unit, Kisumu, Kenya.
(author)
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Olliaro, Piero L.Univ Oxford, Ctr Trop Med & Global Hlth, Nuffield Dept Med, Oxford, England.
(author)
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Ouedraogo, Jean BoscoInst Rech Sci Sante IRSS, Direct Reg Ouest, Bobo Dioulasso, Burkina Faso.;Ctr Muraz Bobo Dioulasso, Non Transmissible Dis Dept, Bobo Dioulasso, Burkina Faso.;Ctr Muraz Bobo Dioulasso, Non Transmissible Dis Dept, Bobo Dioul Asso, Burkina Faso.
(author)
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Piola, PatriceInst Pasteur Cambodge, Phnom Penh, Cambodia.
(author)
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Plowe, Christopher, VDuke Univ, Duke Global Hlth Inst, Durham, NC USA.
(author)
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Plucinski, Mateusz M.US Ctr Dis Control & Prevent, US Presidents Malaria Initiat, Malaria Branch, Div Parasit Dis & Malaria, Atlanta, GA USA.;Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA USA.
(author)
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Pratt, Oliver JamesMinist Hlth & Social Welf, Natl Malaria Control Program, Monrovia, Liberia.
(author)
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Premji, ZulfikaraliMuhimbili Univ, Coll Hlth Sci, Dar Es Salaam, Tanzania.
(author)
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Ramharter, MichaelUniv Med Ctr Hamburg Eppendorf, Dept Trop Med, Bernhard Nocht Inst Trop Med, Hamburg, Germany.;Univ Med Ctr Hamburg Eppendorf, Dept Med 1, Hamburg, Germany.;Univ Tubingen, Inst Tropenmed, Tubingen, Germany.
(author)
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Rogier, ChristopheInst Pasteur, BP 923, Bangui, Cent Afr Republ.;French Armed Forces Biomed Res Inst IRBA, Marseille, France.
(author)
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Vitare, PrimumIfakara Hlth Inst, Dar Es Salaam, Tanzania.
(author)
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Rombo, LarsUppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD)(Swepub:uu)larra728
(author)
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Rosenthal, Philip J.Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA.
(author)
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Sibley, CarolWorld Wide Antimalarial Resistance Network WWARN, Oxford, England.;Univ Washington, Dept Genome Sci, Seattle, WA USA.
(author)
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Sirima, SodiomonGrp Rech Act Sante GRAS, 06 BP 10248, Ouagadougou 06, Burkina Faso.
(author)
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Smithuis, FrankMyanmar Oxford Clin Res Unit, Oxford, England.;Med Act Myanmar, Yangon, Myanmar.
(author)
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Staedke, Sarah G.Infect Dis Res Collaborat, Kampala, Uganda.;London Sch Hyg & Trop Med, Dept Clin Res, London, England.
(author)
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Sutanto, IngeUniv Indonesia, Fac Med, Dept Parasitol, 6 Salemba Raya, Jakarta 10430, Indonesia.
(author)
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Talisuna, Ambrose OtauWorld Hlth Org, Reg Off Africa, Brazzaville, Rep Congo.
(author)
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Tarning, JoelUniv Oxford, Ctr Trop Med & Global Hlth, Nuffield Dept Med, Oxford, England.;WorldWide Antimalarial Resistance Network, Oxford, England.;Mahidol Univ, Fac Trop Med, Mahidol Oxford Trop Med Res Unit, Bangkok, Thailand.
(author)
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Taylor, Walter R. J.Ctr Rech Med Lambarene, Lambarene, Gabon.;Mahidol Univ, Fac Trop Med, Bangkok, Thailand.
(author)
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Temu, EmmanuelUNOPS RBM Partnership End Malaria, Geneva, Switzerland.
(author)
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Thriemer, KamalaCharles Darwin Univ, Menzies Sch Hlth Res, Global & Trop Hlth Div, Darwin, NT, Australia.
(author)
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Thuy-Nhien, NguyenOxford Univ Clin Res Unit OUCRU, Ctr Trop Med, Wellcome Trust Major Overseas Program MOP, Oxford, England.
(author)
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Udhayakumar, VenkatachalamCtr Dis Control & Prevent, Malaria Branch, Div Parasit Dis & Malaria, Ctr Global Hlth, Atlanta, GA USA.;Ctr Dis Control & Prevent, Presidents Malaria Initiat, Div Parasit Dis & Malaria, Ctr Global Hlth, Atlanta, GA USA.
(author)
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Ursing, Johan D.Indepth Network, Bandim Hlth Project, Apartado 861, Bissau, Guinea Bissau.;Danderyd Hosp, Karolinska Inst, Epartment Clin Sci, Stockholm, Sweden.;Danderyd Hosp, Dept Infect Dis, Stockholm, Sweden.
(author)
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van Herp, MichelOperat Ctr Brussels, Med Sans Frontieres, Brussels, Belgium.
(author)
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van Lenthe, MaritMed Sans Frontieres Operat Ctr Amsterdam, Amsterdam, Netherlands.
(author)
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van Vugt, MicheleUniv Amsterdam, Acad Med Ctr, Ctr Trop Med & Travel Med, Div Infect Dis, Amsterdam, Netherlands.
(author)
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William, YavoUniv Cocody, Fac Pharm, Dept Parasitol, Abidjan, Cote Ivoire.
(author)
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Winnips, CornelisNovartis Int AG, Basel, Switzerland.
(author)
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Zaloumis, Sophie
(author)
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Zongo, IssakaInst Rech Sci Sante IRSS, Direct Reg Ouest, Bobo Dioulasso, Burkina Faso.
(author)
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White, Nick J.Univ Oxford, Ctr Trop Med & Global Hlth, Nuffield Dept Med, Oxford, England.;Mahidol Oxford Res Unit, Bangkok, Thailand.
(author)
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Guerin, Philippe J.World Wide Antimalarial Resistance Network WWARN, Oxford, England.;Infect Dis Data Observ IDDO, Oxford, England.;Univ Oxford, Ctr Trop Med & Global Hlth, Nuffield Dept Med, Oxford, England.
(author)
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Stepniewska, KasiaWorld Wide Antimalarial Resistance Network WWARN, Oxford, England.;Infect Dis Data Observ IDDO, Oxford, England.;Univ Oxford, Ctr Trop Med & Global Hlth, Nuffield Dept Med, Oxford, England.
(author)
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Price, Ric N.World Wide Antimalarial Resistance Network WWARN, Oxford, England.;Univ Oxford, Ctr Trop Med & Global Hlth, Nuffield Dept Med, Oxford, England.;Menzies Sch Hlth Res, Darwin, NT, Australia.;Charles Darwin Univ, Darwin, NT, Australia.
(author)
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Arinaitwe, EmmanuelInfect Dis Res Collaborat, Kampala, Uganda.
(author)
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World Wide Antimalarial Resistance Network WWARN, Oxford, England.;Infect Dis Data Observ IDDO, Oxford, England.;Univ Oxford, Ctr Trop Med & Global Hlth, Nuffield Dept Med, Oxford, England.Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia.
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