Low-Modulus PMMA Has the Potential to Reduce Stresses on Endplates after Cement Discoplasty

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Lewin, SusanneUppsala universitet,Institutionen för materialvetenskap (författare)

Low-Modulus PMMA Has the Potential to Reduce Stresses on Endplates after Cement Discoplasty

Artikel/kapitelEngelska2022

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2022-02-04
MDPI,2022
electronicrdacarrier

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LIBRIS-ID:oai:DiVA.org:uu-472742
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-472742URI
https://doi.org/10.3390/jfb13010018DOI

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Språk:engelska
Sammanfattning på:engelska

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Cement discoplasty has been developed to treat patients with advanced intervertebral disc degeneration. In discoplasty, poly(methylmethacrylate) (PMMA) bone cement is injected into the disc, leading to reduced pain and certain spinal alignment correction. Standard PMMA-cements have much higher elastic modulus than the surrounding vertebral bone, which may lead to a propensity for adjacent fractures. A PMMA-cement with lower modulus might be biomechanically beneficial. In this study, PMMA-cements with lower modulus were obtained using previously established methods. A commercial PMMA-cement (V-steady(R), G21 srl) was used as control, and as base cement. The low-modulus PMMA-cements were modified by 12 vol% (LA12), 16 vol% (LA16) and 20 vol% (LA20) linoleic acid (LA). After storage in 37 degrees C PBS from 24 h up to 8 weeks, specimens were tested in compression to obtain the material properties. A lower E-modulus was obtained with increasing amount of LA. However, with storage time, the E-modulus increased. Standard and low-modulus PMMA discoplasty were compared in a previously developed and validated computational lumbar spine model. All discoplasty models showed the same trend, namely a substantial reduction in range of motion (ROM), compared to the healthy model. The V-steady model had the largest ROM-reduction (77%), and the LA20 model had the smallest (45%). The average stress at the endplate was higher for all discoplasty models than for the healthy model, but the stresses were reduced for cements with higher amounts of LA. The study indicates that low-modulus PMMA is promising for discoplasty from a mechanical viewpoint. However, validation experiments are needed, and the clinical setting needs to be further considered.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Ortopedi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Orthopaedics hsv//eng
bone cement
discoplasty
PMMA
low-modulus
lumbar spine

Biuppslag (personer, institutioner, konferenser, titlar ...)

Försth, Peter,1966-Uppsala universitet,Ortopedi(Swepub:uu)petfo877 (författare)
Persson, CeciliaUppsala universitet,Tillämpad materialvetenskap(Swepub:uu)cecpe877 (författare)
Uppsala universitetInstitutionen för materialvetenskap (creator_code:org_t)

Sammanhörande titlar

Ingår i:Journal of Functional Biomaterials: MDPI13:12079-4983

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Av författaren/redakt...: Lewin, Susanne; Försth, Peter, 1 ...; Persson, Cecilia

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Ortopedi

Artiklar i publikationen: Journal of Funct ...

Av lärosätet: Uppsala universitet

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