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Sökning: WFRF:(Schulze Matthias B) > (2020-2024) > Blood copper and ri...

Blood copper and risk of cardiometabolic diseases : a Mendelian randomization study

Jäger, Susanne (författare)
German Inst Human Nutr Potsdam Rehbrucke, Dept Mol Epidemiol, Arthur Scheunert Allee 114-116, D-14558 Nuthetal, Germany.;German Ctr Diabet Res DZD, D-85764 Neuherberg, Germany.;TraceAge DFG Res Unit Interact Essential Trace El, Potsdam, Germany.
Cabral, Maria (författare)
German Inst Human Nutr Potsdam Rehbrucke, Dept Mol Epidemiol, Arthur Scheunert Allee 114-116, D-14558 Nuthetal, Germany.;German Ctr Diabet Res DZD, D-85764 Neuherberg, Germany.;TraceAge DFG Res Unit Interact Essential Trace El, Potsdam, Germany.
Kopp, Johannes F. (författare)
TraceAge DFG Res Unit Interact Essential Trace El, Potsdam, Germany.;Univ Potsdam, Inst Nutr Sci, Dept Food Chem, D-14558 Nuthetal, Germany.
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Hoffmann, Per (författare)
Univ Basel, Dept Biomed, Human Genom Res Grp, CH-4031 Basel, Switzerland.;Univ Hosp Bonn, Life & Brain Res Ctr, Inst Human Genet, Div Genom, D-53105 Bonn, Germany.
Ng, Esther (författare)
Univ Oxford, Wellcome Ctr Human Genet, Oxford OX3 7BN, England.
Whitfield, John B. (författare)
QIMR Berghofer Med Res Inst, Brisbane, Qld 4029, Australia.
Morris, Andrew P. (författare)
Univ Manchester, Ctr Genet & Genom Versus Arthrit, Ctr Musculoskeletal Res, Manchester M13 9PL, Lancs, England.
Lind, Lars (författare)
Uppsala universitet,Klinisk epidemiologi
Schwerdtle, Tanja (författare)
TraceAge DFG Res Unit Interact Essential Trace El, Potsdam, Germany.;Univ Potsdam, Inst Nutr Sci, Dept Food Chem, D-14558 Nuthetal, Germany.;German Fed Inst Risk Assessment BfR, Dept Food Safety, D-10589 Berlin, Germany.
Schulze, Matthias B. (författare)
German Inst Human Nutr Potsdam Rehbrucke, Dept Mol Epidemiol, Arthur Scheunert Allee 114-116, D-14558 Nuthetal, Germany.;German Ctr Diabet Res DZD, D-85764 Neuherberg, Germany.;TraceAge DFG Res Unit Interact Essential Trace El, Potsdam, Germany.;Univ Potsdam, Inst Nutr Sci, D-14558 Nuthetal, Germany.
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German Inst Human Nutr Potsdam Rehbrucke, Dept Mol Epidemiol, Arthur Scheunert Allee 114-116, D-14558 Nuthetal, Germany;German Ctr Diabet Res DZD, D-85764 Neuherberg, Germany.;TraceAge DFG Res Unit Interact Essential Trace El, Potsdam, Germany. TraceAge DFG Res Unit Interact Essential Trace El, Potsdam, Germany.;Univ Potsdam, Inst Nutr Sci, Dept Food Chem, D-14558 Nuthetal, Germany. (creator_code:org_t)
2021-09-15
2022
Engelska.
Ingår i: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 31:5, s. 783-791
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https://doi.org/10.1...
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https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Observational evidence links higher blood levels of copper with higher risk of cardiovascular diseases. However, whether those associations reflect causal links or can be attributed to confounding is still not fully clear. We investigated causal effects of copper on the risk of cardiometabolic endpoints (stroke, coronary artery disease [CAD] and type 2 diabetes) and cardiometabolic risk factors in two-sample Mendelian randomization (MR) studies. The selection of genetic instruments for blood copper levels relied on meta-analysis of genome-wide association studies in three independent studies (European Prospective Investigation into Cancer and Nutrition-Potsdam study, Prospective investigation of the Vasculature in Uppsala Seniors study, Queensland Institute of Medical Research studies). For the selected instruments, outcome associations were drawn from large public genetic consortia on the respective disease endpoints (MEGASTROKE, Cardiogram, DIAGRAM) and cardiometabolic risk factors. MR results indicate an inverse association for genetically higher copper levels with risk of CAD (odds ratio [95% confidence interval] = 0.92 [0.86-0.99], P = 0.022) and systolic blood pressure (beta [standard error (SE)] = -0.238 [0.121]; P = 0.049). Multivariable MR incorporating copper and systolic blood pressure into one model suggested systolic blood pressure as mediating factor between copper and CAD risk. In contrast to previous observational evidence establishing higher blood copper levels as risk-increasing factor for cardiometabolic diseases, this study suggests that higher levels of genetically predicted copper might play a protective role for the development of CAD and systolic blood pressure.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

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