SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Carbonell J.)
 

Search: WFRF:(Carbonell J.) > Mutation bias refle...

  • Monroe, J. GreyMax Planck Inst Biol Tubingen, Dept Mol Biol, Tubingen, Germany.;Univ Calif Davis, Dept Plant Sci, Davis, CA 95616 USA. (author)

Mutation bias reflects natural selection in Arabidopsis thaliana

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2022-01-12
  • Springer Nature,2022
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-473202
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-473202URI
  • https://doi.org/10.1038/s41586-021-04269-6DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Since the first half of the twentieth century, evolutionary theory has been dominated by the idea that mutations occur randomly with respect to their consequences(1). Here we test this assumption with large surveys of de novo mutations in the plant Arabidopsis thaliana. In contrast to expectations, we find that mutations occur less often in functionally constrained regions of the genome-mutation frequency is reduced by half inside gene bodies and by two-thirds in essential genes. With independent genomic mutation datasets, including from the largest Arabidopsis mutation accumulation experiment conducted to date, we demonstrate that epigenomic and physical features explain over 90% of variance in the genome-wide pattern of mutation bias surrounding genes. Observed mutation frequencies around genes in turn accurately predict patterns of genetic polymorphisms in natural Arabidopsis accessions (r = 0.96). That mutation bias is the primary force behind patterns of sequence evolution around genes in natural accessions is supported by analyses of allele frequencies. Finally, we find that genes subject to stronger purifying selection have a lower mutation rate. We conclude that epigenome-associated mutation bias2 reduces the occurrence of deleterious mutations in Arabidopsis, challenging the prevailing paradigm that mutation is a directionless force in evolution.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Srikant, ThanviMax Planck Inst Biol Tubingen, Dept Mol Biol, Tubingen, Germany. (author)
  • Carbonell-Bejerano, PabloMax Planck Inst Biol Tubingen, Dept Mol Biol, Tubingen, Germany. (author)
  • Becker, ClaudeMax Planck Inst Biol Tubingen, Dept Mol Biol, Tubingen, Germany.;Ludwig Maximilians Univ Munchen, Fac Biol, Martinsried, Germany. (author)
  • Lensink, MarieleUniv Calif Davis, Dept Plant Sci, Davis, CA 95616 USA. (author)
  • Exposito-Alonso, MoisesCarnegie Inst Sci, Dept Plant Biol, 290 Panama St, Stanford, CA 94305 USA.;Stanford Univ, Dept Biol, Stanford, CA 94305 USA. (author)
  • Klein, MarieMax Planck Inst Biol Tubingen, Dept Mol Biol, Tubingen, Germany.;Univ Calif Davis, Dept Plant Sci, Davis, CA 95616 USA. (author)
  • Hildebrandt, JuliaMax Planck Inst Biol Tubingen, Dept Mol Biol, Tubingen, Germany. (author)
  • Neumann, ManuelaMax Planck Inst Biol Tubingen, Dept Mol Biol, Tubingen, Germany. (author)
  • Kliebenstein, DanielUniv Calif Davis, Dept Plant Sci, Davis, CA 95616 USA. (author)
  • Weng, Mao-LunWestfield State Univ, Dept Biol, Westfield, MA USA. (author)
  • Imbert, EricUniv Montpellier, ISEM, Montpellier, France. (author)
  • Ågren, JonUppsala universitet,Växtekologi och evolution(Swepub:uu)jonagren (author)
  • Rutter, Matthew T.Coll Charleston, Dept Biol, Charleston, SC 29401 USA. (author)
  • Fenster, Charles B.South Dakota State Univ, Oak Lake Field Stn, Brookings, SD 57007 USA. (author)
  • Weigel, DetlefMax Planck Inst Biol Tubingen, Dept Mol Biol, Tubingen, Germany. (author)
  • Max Planck Inst Biol Tubingen, Dept Mol Biol, Tubingen, Germany.;Univ Calif Davis, Dept Plant Sci, Davis, CA 95616 USA.Max Planck Inst Biol Tubingen, Dept Mol Biol, Tubingen, Germany. (creator_code:org_t)

Related titles

  • In:Nature: Springer Nature602:7895, s. 101-1050028-08361476-4687

Internet link

Find in a library

  • Nature (Search for host publication in LIBRIS)

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view