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Mutation bias refle...
Mutation bias reflects natural selection in Arabidopsis thaliana
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- Monroe, J. Grey (author)
- Max Planck Inst Biol Tubingen, Dept Mol Biol, Tubingen, Germany.;Univ Calif Davis, Dept Plant Sci, Davis, CA 95616 USA.
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- Srikant, Thanvi (author)
- Max Planck Inst Biol Tubingen, Dept Mol Biol, Tubingen, Germany.
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- Carbonell-Bejerano, Pablo (author)
- Max Planck Inst Biol Tubingen, Dept Mol Biol, Tubingen, Germany.
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- Becker, Claude (author)
- Max Planck Inst Biol Tubingen, Dept Mol Biol, Tubingen, Germany.;Ludwig Maximilians Univ Munchen, Fac Biol, Martinsried, Germany.
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- Lensink, Mariele (author)
- Univ Calif Davis, Dept Plant Sci, Davis, CA 95616 USA.
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- Exposito-Alonso, Moises (author)
- Carnegie Inst Sci, Dept Plant Biol, 290 Panama St, Stanford, CA 94305 USA.;Stanford Univ, Dept Biol, Stanford, CA 94305 USA.
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- Klein, Marie (author)
- Max Planck Inst Biol Tubingen, Dept Mol Biol, Tubingen, Germany.;Univ Calif Davis, Dept Plant Sci, Davis, CA 95616 USA.
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- Hildebrandt, Julia (author)
- Max Planck Inst Biol Tubingen, Dept Mol Biol, Tubingen, Germany.
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- Neumann, Manuela (author)
- Max Planck Inst Biol Tubingen, Dept Mol Biol, Tubingen, Germany.
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- Kliebenstein, Daniel (author)
- Univ Calif Davis, Dept Plant Sci, Davis, CA 95616 USA.
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- Weng, Mao-Lun (author)
- Westfield State Univ, Dept Biol, Westfield, MA USA.
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- Imbert, Eric (author)
- Univ Montpellier, ISEM, Montpellier, France.
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- Ågren, Jon (author)
- Uppsala universitet,Växtekologi och evolution
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- Rutter, Matthew T. (author)
- Coll Charleston, Dept Biol, Charleston, SC 29401 USA.
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- Fenster, Charles B. (author)
- South Dakota State Univ, Oak Lake Field Stn, Brookings, SD 57007 USA.
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- Weigel, Detlef (author)
- Max Planck Inst Biol Tubingen, Dept Mol Biol, Tubingen, Germany.
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Max Planck Inst Biol Tubingen, Dept Mol Biol, Tubingen, Germany;Univ Calif Davis, Dept Plant Sci, Davis, CA 95616 USA. Max Planck Inst Biol Tubingen, Dept Mol Biol, Tubingen, Germany. (creator_code:org_t)
- 2022-01-12
- 2022
- English.
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In: Nature. - : Springer Nature. - 0028-0836 .- 1476-4687. ; 602:7895, s. 101-105
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Abstract
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- Since the first half of the twentieth century, evolutionary theory has been dominated by the idea that mutations occur randomly with respect to their consequences(1). Here we test this assumption with large surveys of de novo mutations in the plant Arabidopsis thaliana. In contrast to expectations, we find that mutations occur less often in functionally constrained regions of the genome-mutation frequency is reduced by half inside gene bodies and by two-thirds in essential genes. With independent genomic mutation datasets, including from the largest Arabidopsis mutation accumulation experiment conducted to date, we demonstrate that epigenomic and physical features explain over 90% of variance in the genome-wide pattern of mutation bias surrounding genes. Observed mutation frequencies around genes in turn accurately predict patterns of genetic polymorphisms in natural Arabidopsis accessions (r = 0.96). That mutation bias is the primary force behind patterns of sequence evolution around genes in natural accessions is supported by analyses of allele frequencies. Finally, we find that genes subject to stronger purifying selection have a lower mutation rate. We conclude that epigenome-associated mutation bias2 reduces the occurrence of deleterious mutations in Arabidopsis, challenging the prevailing paradigm that mutation is a directionless force in evolution.
Subject headings
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
- NATURVETENSKAP -- Biologi -- Evolutionsbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Evolutionary Biology (hsv//eng)
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- art (subject category)
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Monroe, J. Grey
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Srikant, Thanvi
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Carbonell-Bejera ...
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Becker, Claude
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Lensink, Mariele
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Exposito-Alonso, ...
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Klein, Marie
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Hildebrandt, Jul ...
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Neumann, Manuela
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Kliebenstein, Da ...
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Weng, Mao-Lun
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Imbert, Eric
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Ågren, Jon
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Rutter, Matthew ...
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Fenster, Charles ...
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Weigel, Detlef
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Genetics
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Evolutionary Bio ...
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Uppsala University