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- Delgado-Vega, Angelica MariaUppsala universitet,Institutionen för immunologi, genetik och patologi,Department of Immunology, Genetics, and Pathology, Uppsala, Sweden (author)
Family History and Warning Symptoms Precede Sudden Cardiac Death in Arrhythmogenic Right Ventricular Cardiomyopathy (From A Nationwide Study in Sweden)
- Article/chapterEnglish2022
Publisher, publication year, extent ...
- Elsevier,2022
- electronicrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:uu-473209
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-473209URI
- https://doi.org/10.1016/j.amjcard.2022.05.015DOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-198303URI
Supplementary language notes
- Language:English
- Summary in:English
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Notes
- Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited cardiacdisease explaining about 4% of sudden cardiac death (SCD) cases among the youngin Sweden. The aim of this study was to describe the circumstances preceding SCDdue to ARVC in all victims <35 years of age who received an autopsy-confirmeddiagnosis of ARVC from January 1st, 2000 to December 31st, 2010 in Sweden (n=22).Data on demographics, medical and family history, circumstances of death, andanatomopathological findings were collected from several compulsory national healthregistries, clinical records, family interviews, and autopsy reports. Registry-based datawas compared with age-, sex- and geographically-matched population controls. Duringthe 6 months preceding SCD, 15 cases (68%) had experienced symptoms of cardiacorigin, mainly syncope or presyncope (54%), and chest discomfort (27%). Eight cases(36%) had sought medical care due to cardiac symptoms. The occurrence of hospitalvisits was significantly increased in cases compared with controls (OR 4.62 [1.35-15.8]). Ten cases (45%) had a family history of SCD. The most common activity at thetime of death was exercise (41%). Complete cardiac investigation was seldomperformed, only one case was diagnosed with ARVC before death. In conclusion, inthis nationwide study we observed a high prevalence of symptoms of cardiac origin,health-care utilization, and family history of SCD preceding SCD due to ARVC amongthe young. Increased awareness of these warning signals in the young is critical toimprove risk stratification and early disease detection.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
- Arrhythmogenic Right Ventricular Cardiomyopathy
- symptoms
- family history
- sudden cardiac death
- Kardiologi
- Cardiology
Added entries (persons, corporate bodies, meetings, titles ...)
- Kommata, VarvaraUppsala universitet,Institutionen för medicinska vetenskaper,Department of Medical Sciences, Cardiology, Uppsala, Sweden(Swepub:uu)varko390 (author)
- Svennblad, BodilUppsala universitet,Medicinsk epidemiologi,Department of Surgical Sciences, Uppsala University, Uppsala, Sweden(Swepub:uu)bosve677 (author)
- Wisten, AaseUmeå universitet,Institutionen för samhällsmedicin och rehabilitering,Umeå Universitet(Swepub:umu)aawi0001 (author)
- Hagström, EmilUppsala universitet,Institutionen för medicinska vetenskaper,Department of Medical Sciences, Cardiology, Uppsala, Sweden(Swepub:uu)emhag677 (author)
- Stattin, EvalenaUppsala universitet,Institutionen för immunologi, genetik och patologi(Swepub:uu)evast375 (author)
- Stattin, Eva-LenaDepartment of Immunology, Genetics, and Pathology, Uppsala, Sweden (author)
- Uppsala universitetInstitutionen för immunologi, genetik och patologi (creator_code:org_t)
Related titles
- In:American Journal of Cardiology: Elsevier178, s. 124-1300002-91491879-1913
Internet link
- https://doi.org/10.1016/j.amjcard.2022.05.015Fulltext
- https://uu.diva-portal.org/smash/get/diva2:1653686/FULLTEXT01.pdffulltext:print
- https://umu.diva-portal.org/smash/get/diva2:1684926/FULLTEXT02.pdffulltext:print
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-473209
- https://doi.org/10.1016/j.amjcard.2022.05.015
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-198303
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