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Sökning: id:"swepub:oai:DiVA.org:uu-473572" > Validation of modif...

  • Kaegi-Braun, NinaKantonsspital Aarau, Div Gen Internal & Emergency Med, Med Univ Dept, Aarau, Switzerland. (författare)

Validation of modified GLIM criteria to predict adverse clinical outcome and response to nutritional treatment : A secondary analysis of a randomized clinical trial

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • Elsevier,2022
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-473572
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-473572URI
  • https://doi.org/10.1016/j.clnu.2022.02.009DOI

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  • Språk:engelska
  • Sammanfattning på:engelska

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  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background & aims: The Global Leadership Initiative on Malnutrition (GLIM) recently suggested specific criteria to standardize the diagnosis of malnutrition. There is need for validation of these criteria regarding response to nutrition treatment. Our aim was to validate modified GLIM (mGLIM) criteria among medical inpatients at risk of disease related malnutrition for prediction of outcome and response to nutritional therapy.Methods: This is a secondary analysis of the Effect of Early Nutritional Support on Frailty, Functional Outcomes, and Recovery of Malnourished Medical Inpatients Trial (EFFORT), a multicenter randomized controlled trial conducted between April 2014 and February 2018. Adult medical inpatients at nutritional risk (Nutrition Risk Score 2002 > 3 points) were randomly assigned to receive nutritional therapy according to an algorithm based on individualized nutritional requirements (intervention group) or standard hospital food (control group). We included all participants with available information regarding mGLIM criteria. The primary outcome was adverse clinical outcome, which was a composite of 30-day all-cause mortality, ICU-admission, rehospitalization rate, major complications and decline in functional status.Results: Of 1917 eligible participants at nutritional risk, 1181 (61.6%) met the diagnosis of malnutrition based on mGLIM criteria. The incidence of adverse clinical outcome was significantly higher in mGLIMpositive participants compared with mGLIM-negative participants [330/1181 (27.9%) versus 140/736 (19.0%); multivariable adjusted odds ratio [OR] 1.53; 95% CI 1.22-1.93; p < 0.001]. Regarding the effect of nutritional therapy, the reduction in adverse clinical outcomes was higher in mGLIM-positive participants [180/581 (31.0%) vs. 150/600 (25.0%), OR 0.69; 95% CI 0.53-0.9, p = 0.007], compared with mGLIMnegative participants [75/379 (19.8%) versus 65/357 (18.2%), OR 0.95; 95% CI 0.65-1.40, p = 0.797], a finding that was, however, not significant in interaction analysis (p for interaction = 0.217).Conclusion: Data from this secondary analysis of a multicenter randomized trial involving medical inpatients at nutritional risk validate the strong prognostic value of mGLIM criteria regarding adverse clinical outcomes and other long-term outcomes. However, further research is needed to improve the ability of GLIM criteria to predict therapeutic response to nutritional interventions.Trial registration: ClinicalTrials.gov Identifier: NCT02517476.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Boesiger, FabienneKantonsspital Aarau, Div Gen Internal & Emergency Med, Med Univ Dept, Aarau, Switzerland. (författare)
  • Tribolet, PascalBern Univ Appl Sci, Dept Hlth Profess, Bern, Switzerland.;Univ Vienna, Fac Life Sci, Vienna, Austria. (författare)
  • Gomes, FilomenaNew York Acad Sci, New York, NY USA.;Univ Nova Lisboa, NOVA Med Sch, Lisbon, Portugal. (författare)
  • Kutz, AlexanderKantonsspital Aarau, Div Gen Internal & Emergency Med, Med Univ Dept, Aarau, Switzerland. (författare)
  • Hoess, ClausKantonsspital Munsterlingen, Internal Med, Munsterlingen, Switzerland. (författare)
  • Pavlicek, VojtechKantonsspital Munsterlingen, Internal Med, Munsterlingen, Switzerland. (författare)
  • Bilz, StefanKantonsspital St Gallen, Internal Med & Endocrinol, St Gallen, Switzerland. (författare)
  • Sigrist, SarahKantonsspital St Gallen, Internal Med & Endocrinol, St Gallen, Switzerland. (författare)
  • Brändle, MichaelKantonsspital St Gallen, Internal Med & Endocrinol, St Gallen, Switzerland. (författare)
  • Henzen, ChristophKantonsspital Luzern, Internal Med, Luzern, Switzerland. (författare)
  • Thomann, RobertBurgerspital, Internal Med, Solothurn, Switzerland. (författare)
  • Rutishauser, JonasKantonsspital Baselland, Internal Med, Standort Bruderholz, Switzerland. (författare)
  • Aujesky, DrahomirUniv Bern, Bern Univ Hosp, Dept Gen Internal Med, Inselspital, Bern, Switzerland. (författare)
  • Rodondi, NicolasUniv Bern, Bern Univ Hosp, Dept Gen Internal Med, Inselspital, Bern, Switzerland.;Univ Bern, Inst Primary Hlth Care BIHAM, Bern, Switzerland. (författare)
  • Donze, JacquesUniv Bern, Bern Univ Hosp, Dept Gen Internal Med, Inselspital, Bern, Switzerland.;Brigham & Womens Hosp, Div Gen Internal Med, 75 Francis St, Boston, MA 02115 USA. (författare)
  • Stanga, ZenoUniv Bern, Bern Univ Hosp, Div Diabet Endocrinol Nutr Med & Metab, Inselspital, Bern, Switzerland. (författare)
  • Lobo, Dileep N.Nottingham Digest Dis Ctr, Nottingham, England.;Nottingham Univ Hosp NHS Trust, Natl Inst Hlth Res, Nottingham Biomed Res Ctr, Nottingham, England.;Univ Nottingham, Queens Med Ctr, Nottingham, England.;Univ Nottingham, MRC Versus Arthrit Ctr Musculoskeletal Ageing Res, Queens Med Ctr, Sch Life Sci, Nottingham, England. (författare)
  • Cederholm, TommyUppsala universitet,Klinisk nutrition och metabolism,Karolinska Univ Hosp, Theme Inflammat & Aging, Stockholm, Sweden.(Swepub:uu)tomce419 (författare)
  • Mueller, BeatKantonsspital Aarau, Div Gen Internal & Emergency Med, Med Univ Dept, Aarau, Switzerland.;Univ Basel, Med Fac, Basel, Switzerland. (författare)
  • Schuetz, PhilippKantonsspital Aarau, Div Gen Internal & Emergency Med, Med Univ Dept, Aarau, Switzerland.;Univ Basel, Med Fac, Basel, Switzerland. (författare)
  • Kantonsspital Aarau, Div Gen Internal & Emergency Med, Med Univ Dept, Aarau, Switzerland.Bern Univ Appl Sci, Dept Hlth Profess, Bern, Switzerland.;Univ Vienna, Fac Life Sci, Vienna, Austria. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Clinical Nutrition: Elsevier41:4, s. 795-8040261-56141532-1983

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