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Composite attenuati...
Composite attenuation correction method using a 68Ge-transmission multi-atlas for quantitative brain PET/MR.
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- Sousa, Joao M., 1989- (author)
- Uppsala universitet,Radiologi
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- Appel, Lieuwe (author)
- Uppsala universitet,Radiologi
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Engström, Mathias (author)
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Papadimitriou, Stergios (author)
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- Nyholm, Dag (author)
- Uppsala universitet,Landtblom: Neurovetenskap
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- Ahlström, Håkan, 1953- (author)
- Uppsala universitet,Radiologi
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- Lubberink, Mark (author)
- Uppsala universitet,Radiologi
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(creator_code:org_t)
- Elsevier, 2022
- 2022
- English.
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In: Physica medica (Testo stampato). - : Elsevier. - 1120-1797 .- 1724-191X. ; 97, s. 36-43
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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Abstract
Subject headings
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- In positron emission tomography (PET), 68Ge-transmission scanning is considered the gold standard in attenuation correction (AC) though not available in current dual imaging systems. In this experimental study we evaluated a novel AC method for PET/magnetic resonance (MR) imaging which is essentially based on a composite database of multiple 68Ge-transmission maps and T1-weighted (T1w) MR image-pairs (composite transmission, CTR-AC). This proof-of-concept study used retrospectively a database with 125 pairs of co-registered 68Ge-AC maps and T1w MR images from anatomical normal subjects and a validation dataset comprising dynamic [11C]PE2I PET data from nine patients with Parkinsonism. CTR-AC maps were generated by non-rigid image registration of all database T1w MRI to each subject's T1w, applying the same transformation to every 68Ge-AC map, and averaging the resulting 68Ge-AC maps. [11C]PE2I PET images were reconstructed using CTR-AC and a patient-specific 68Ge-AC map as the reference standard. Standardized uptake values (SUV) and quantitative parameters of kinetic analysis were compared, i.e., relative delivery (R1) and non-displaceable binding potential (BPND). CTR-AC showed high accuracy for whole-brain SUV (mean %bias ± SD: 0.5 ± 3.5%), whole-brain R1 (-0.1 ± 3.2%), and putamen BPND (3.7 ± 8.1%). SUV and R1 precision (SD of %bias) were modest and lowest in the anterior cortex, with an R1 %bias of -1.1 ± 6.4%). The prototype CTR-AC is capable of providing accurate MRAC-maps with continuous linear attenuation coefficients though still experimental. The method's accuracy is comparable to the best MRAC methods published so far, both in SUV and as found for ZTE-AC in quantitative parameters of kinetic modelling.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- (68)Ge-transmission scan
- Attenuation correction
- Hybrid imaging
- Kinetic modelling
- PET/MRI
- [(11)C]PE2I
Publication and Content Type
- ref (subject category)
- art (subject category)
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