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Biological aging markers in blood and brain tissue indicate age acceleration in alcohol use disorder

Zillich, Lea (författare)
Heidelberg Univ, Cent Inst Mental Hlth, Med Fac Mannheim, Dept Genet epidemiol Psychiat, Mannheim, Germany.;NIAAA, Sect Clin Genom & Expt Therapeut, NIH, Bethesda, MD USA.;Cent Inst Mental Hlth, Dept Genet Epidemiol Psychiat, J5, D-68159 Mannheim, Germany.
Cetin, Metin (författare)
Heidelberg Univ, Cent Inst Mental Hlth, Med Fac Mannheim, Dept Genet epidemiol Psychiat, Mannheim, Germany.
Hummel, Elisabeth M. (författare)
Ruhr Univ Bochum, Fac Psychol, Dept Genet Psychol, Bochum, Germany.
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Poisel, Eric (författare)
Heidelberg Univ, Cent Inst Mental Hlth, Med Fac Mannheim, Dept Genet epidemiol Psychiat, Mannheim, Germany.
Fries, Gabriel R. (författare)
Univ Texas Hlth Sci Ctr Houston, McGovern Med Sch, Louis A Faillace Dept Psychiat & Behav Sci, Houston, TX USA.
Frank, Josef (författare)
Heidelberg Univ, Cent Inst Mental Hlth, Med Fac Mannheim, Dept Genet epidemiol Psychiat, Mannheim, Germany.
Streit, Fabian (författare)
Heidelberg Univ, Cent Inst Mental Hlth, Med Fac Mannheim, Dept Genet epidemiol Psychiat, Mannheim, Germany.
Foo, Jerome C. (författare)
Heidelberg Univ, Cent Inst Mental Hlth, Med Fac Mannheim, Dept Genet epidemiol Psychiat, Mannheim, Germany.
Sirignano, Lea (författare)
Heidelberg Univ, Cent Inst Mental Hlth, Med Fac Mannheim, Dept Genet epidemiol Psychiat, Mannheim, Germany.
Friske, Marion M. (författare)
Heidelberg Univ, Inst Psychopharmacol, Cent Inst Mental Hlth, Med Fac Mannheim, Mannheim, Germany.
Lenz, Bernd (författare)
Heidelberg Univ, Cent Inst Mental Hlth, Med Fac Mannheim, Dept Addict Behav & Addict Med, Mannheim, Germany.
Hoffmann, Sabine (författare)
Heidelberg Univ, Cent Inst Mental Hlth, Med Fac Mannheim, Dept Addict Behav & Addict Med, Mannheim, Germany.
Adorjan, Kristina (författare)
Ludwig Maximilian Univ Munich, Univ Hosp, Dept Psychiat & Psychotherapy, Munich, Germany.;Ludwig Maximilian Univ Munich, Univ Hosp, Inst Psychiat Phen & Genom, Munich, Germany.
Kiefer, Falk (författare)
Heidelberg Univ, Cent Inst Mental Hlth, Med Fac Mannheim, Dept Addict Behav & Addict Med, Mannheim, Germany.
Bakalkin, Georgy (författare)
Uppsala universitet,Institutionen för farmaceutisk biovetenskap
Hansson, Anita C. (författare)
Heidelberg Univ, Inst Psychopharmacol, Cent Inst Mental Hlth, Med Fac Mannheim, Mannheim, Germany.
Lohoff, Falk W. (författare)
NIAAA, Sect Clin Genom & Expt Therapeut, NIH, Bethesda, MD USA.
Kaerkkaeinen, Olli (författare)
Univ Eastern Finland, Sch Pharm, Kuopio, Finland.
Kok, Eloise (författare)
Univ Helsinki, Dept Pathol, Helsinki, Finland.;Helsinki Univ Hosp, HUS Diagnost Ctr, Helsinki, Finland.;Tampere Univ, Fac Med & Hlth Technol, Tampere, Finland.
Karhunen, Pekka J. (författare)
Tampere Univ, Fac Med & Hlth Technol, Tampere, Finland.;Pirkanmaa Hosp Dist, Finnish Cardiovasc Res Ctr Tampere, Tampere, Finland.;Finnish Cardiovasc Res Ctr Tampere, Tampere, Finland.
Sutherland, Greg T. (författare)
Univ Sydney, Fac Med & Hlth, Charles Perkins Ctr, Sydney, NSW, Australia.;Univ Sydney, Sch Med Sci, Sydney, NSW, Australia.
Walss-Bass, Consuelo (författare)
Univ Texas Hlth Sci Ctr Houston, McGovern Med Sch, Louis A Faillace Dept Psychiat & Behav Sci, Houston, TX USA.
Spanagel, Rainer (författare)
Heidelberg Univ, Inst Psychopharmacol, Cent Inst Mental Hlth, Med Fac Mannheim, Mannheim, Germany.
Rietschel, Marcella (författare)
Heidelberg Univ, Cent Inst Mental Hlth, Med Fac Mannheim, Dept Genet epidemiol Psychiat, Mannheim, Germany.
Moser, Dirk A. (författare)
Ruhr Univ Bochum, Fac Psychol, Dept Genet Psychol, Bochum, Germany.
Witt, Stephanie H. (författare)
Heidelberg Univ, Cent Inst Mental Hlth, Med Fac Mannheim, Dept Genet epidemiol Psychiat, Mannheim, Germany.;Heidelberg Univ, Cent Inst Mental Hlth, Med Fac Mannheim, Ctr Innovat Psychiat & Psychotherapeut Res,Biobank, Mannheim, Germany.
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Heidelberg Univ, Cent Inst Mental Hlth, Med Fac Mannheim, Dept Genet epidemiol Psychiat, Mannheim, Germany;NIAAA, Sect Clin Genom & Expt Therapeut, NIH, Bethesda, MD USA.;Cent Inst Mental Hlth, Dept Genet Epidemiol Psychiat, J5, D-68159 Mannheim, Germany. Heidelberg Univ, Cent Inst Mental Hlth, Med Fac Mannheim, Dept Genet epidemiol Psychiat, Mannheim, Germany. (creator_code:org_t)
John Wiley & Sons, 2024
2024
Engelska.
Ingår i: ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH. - : John Wiley & Sons. - 2993-7175. ; 48:2, s. 250-259
Relaterad länk:
https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • BackgroundAlcohol use disorder (AUD) is associated with increased mortality and morbidity risk. A reason for this could be accelerated biological aging, which is strongly influenced by disease processes such as inflammation. As recent studies of AUD show changes in DNA methylation and gene expression in neuroinflammation-related pathways in the brain, biological aging represents a potentially important construct for understanding the adverse effects of substance use disorders. Epigenetic clocks have shown accelerated aging in blood samples from individuals with AUD. However, no systematic evaluation of biological age measures in AUD across different tissues and brain regions has been undertaken.MethodsAs markers of biological aging (BioAge markers), we assessed Levine's and Horvath's epigenetic clocks, DNA methylation telomere length (DNAmTL), telomere length (TL), and mitochondrial DNA copy number (mtDNAcn) in postmortem brain samples from Brodmann Area 9 (BA9), caudate nucleus, and ventral striatum (N = 63-94), and in whole blood samples (N = 179) of individuals with and without AUD. To evaluate the association between AUD status and BioAge markers, we performed linear regression analyses while adjusting for covariates.ResultsThe majority of BioAge markers were significantly associated with chronological age in all samples. Levine's epigenetic clock and DNAmTL were indicative of accelerated biological aging in AUD in BA9 and whole blood samples, while Horvath's showed the opposite effect in BA9. No significant association of AUD with TL and mtDNAcn was detected. Measured TL and DNAmTL showed only small correlations in blood and none in brain.ConclusionsThe present study is the first to simultaneously investigate epigenetic clocks, telomere length, and mtDNAcn in postmortem brain and whole blood samples in individuals with AUD. We found evidence for accelerated biological aging in AUD in blood and brain, as measured by Levine's epigenetic clock, and DNAmTL. Additional studies of different tissues from the same individuals are needed to draw valid conclusions about the congruence of biological aging in blood and brain.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)

Nyckelord

alcohol use disorder
biological aging
copy numbers of mitochondrial DNA
epigenetic clocks
telomere length

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