International eDelphi Study to Reach Consensus on the Methotrexate Dosing Regimen in Patients With Psoriasis

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International eDelphi Study to Reach Consensus on the Methotrexate Dosing Regimen in Patients With Psoriasis

van Huizen, Astrid M. (författare): Department of Dermatology, Amsterdam UMC, University of Amsterdam, Amsterdam Public Health, Infection and Immunity, Amsterdam, the Netherlands

Menting, Stef P. (författare): Department of Dermatology, OLVG, Amsterdam, the Netherlands

Gyulai, Rolland (författare): Department of Dermatology, University of Pécs, Medical School, Venerology and Oncodermatology, Pécs, Hungary

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Iversen, Lars (författare): Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark

van der Kraaij, Gayle E. (författare): Department of Dermatology, Amsterdam UMC, University of Amsterdam, Amsterdam Public Health, Infection and Immunity, Amsterdam, the Netherlands

Middelkamp-Hup, Maritza A. (författare): Department of Dermatology, Amsterdam UMC, University of Amsterdam, Amsterdam Public Health, Infection and Immunity, Amsterdam, the Netherlands

Warren, Richard B. (författare): The Dermatology Centre, Salford Royal NHS Foundation Trust, The Manchester NIHR Biomedical Research Centre, United Kingdom

Spuls, Phyllis I. (författare): Department of Dermatology, Amsterdam UMC, University of Amsterdam, Amsterdam Public Health, Infection and Immunity, Amsterdam, the Netherlands

Schejtman, Adrián A. (författare): Centro Dermatológico Schejtman, Provincia de Buenos Aires, Argentina

Egeberg, Alexander (författare): Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark

Firooz, Alireza (författare): Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran

Kumar, Alur S. (författare): Apollo Hospital, Secunderabad, Telangana, India

Oakley, Amanda (författare): Waikato District Health Board, University of Auckland, Auckland, New Zealand

Foulkes, Amy (författare): The Dermatology Centre, Salford Royal NHS Foundation Trust, The Manchester NIHR Biomedical Research Centre, United Kingdom

Ramos, Andrea Machado Coelho (författare): Hospital das Clínicas da Universidade Federal de Minas Gerais, Belo Horizonte, Brazil

Fougerousse, Anne-Claire (författare): Military Teaching Hospital Begin, Saint Mandé, France

Čarija, Antoanela (författare): School of Medicine, University of Split, University Hospital Centre Split, Croatia

Akman-Karakaş, Ayse (författare): Department of Dermatology and Venerology, Akdeniz University School of Medicine, Antalya, Turkey

Horváth, Barbara (författare): Department of Dermatology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands

Fábos, Béata (författare): Department of Dermatology, Teaching Hospital Kaposvar, Kaposvar, Hungary

Matlock, Benjamin Hidalgo (författare): University of Costa Rica/Hospital Nacional de Niños, San Pedro Montes de Oca, San Jose Province, Costa Rica

Claréus, Birgitta Wilson (författare): Psoriasis Treatment Wards, Stockholm, Sweden

Castro, Carla (författare): Dermatologist Hospital Universitario Austral, Buenos Aires, Argentina

Ferrándiz, Carlos (författare): Department of Dermatology, Hospital universitario Germans Trias i Pujol, Universidad Autónoma de Barcelona, Barcelona, Spain

Correa, Carolina Cortés (författare): Dermatology Service of La Samaritana University Hospital, Bogotá, Colombia;Pontificia Universidad Javeriana/National University of Colombia, Bogotá, Colombia

Marchesi, Carolina (författare): Proderma, Clínica de la piel, San Juan, Argentina

Goujon, Catherine (författare): Department of Immunology and Clinical Allergology, Lyon sud Hospital, Saint-Genis-Laval, France

Gonzalez, Cesar (författare): Private practice, Bogotá, Colombia

Maldonado-García, César (författare): Centro Dermatologico “Dr. Ladislao de la Pascua,” Mexico City, Mexico

Hong, Chih-ho (författare): Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada

Griffiths, Christopher E.M. (författare): The Dermatology Centre, Salford Royal NHS Foundation Trust, The Manchester NIHR Biomedical Research Centre, United Kingdom,Service de Dermatologie, Hôpital Victor Dupouy, Argenteuil, France

Vestergaard, Christian (författare): Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark

Echeverría, Christina Mariela (författare): Instituto de Rehabilitación Psicofísica, IREP, Buenos Aires, Argentina

de la Cruz, Claudia (författare): Clinica Dermacross, Santiago, Chile

Conrad, Curdin (författare): Department of Dermatology, Lausanne University Hospital CHUV, Lausanne, Switzerland

Törőcsik, Dániel (författare): Department of Dermatology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary

Drvar, Daniela Ledić (författare): Department of Dermatology and Venereology, University Hospital Centre Zagreb, School of Medicine University of Zagreb, Croatia

Balak, Deepak (författare): Department of Dermatology, Ghent University Hospital, Ghent, Belgium

Jullien, Denis (författare): Hospices Civils de Lyon, Hôpital E. Herriot, Service de Dermatologie, Lyon, France

Appelen, Diebrecht (författare): Radboud University Medical Center, Nijmegen, the Netherlands

Kim, Dong Hyun (författare): Department of Dermatology, CHA Bundang Medical Center, CHA University College of Medicine, Seongnam, Republic of Korea

de Jong, Elke M.G.J. (författare): Radboud University Medical Center, Nijmegen, the Netherlands

El Gamal, Emad (författare): Damietta Faculty of Medicine, Al-Azhar University, Cairo, Egypt

Laffitte, Emmanuel (författare): Department of Dermatology, University Hospital of Geneva, Geneva, Switzerland

Mahé, Emmanuel (författare): Service de Dermatologie, Hôpital Victor Dupouy, Argenteuil, France

Sonkoly, Enikö (författare): Uppsala universitet,Dermatologi och venereologi

Colombo, Erika Páez (författare): Hospital Vargas de Caracas, Venezuela

Vilarrasa, Eva (författare): Dermatology Department, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain

Willaert, Fabienne (författare): Hôpital ERASME, Université Libre de Bruxelles, Anderlecht, Belgium

Novoa, Farah D. (författare): Private practice, Santiago de Surco, Peru

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American Medical Association (AMA), 2022
2022
Engelska.
Ingår i: JAMA dermatology. - : American Medical Association (AMA). - 2168-6068 .- 2168-6084. ; 158:5, s. 561-561

Relaterad länk:: https://jamanetwork....; visa fler...; https://urn.kb.se/re...; https://doi.org/10.1...; http://kipublication...; visa färre...

Tidskriftsartikel (refereegranskat)

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Importance A clear dosing regimen for methotrexate in psoriasis is lacking, and this might lead to a suboptimal treatment. Because methotrexate is affordable and globally available, a uniform dosing regimen could potentially optimize the treatment of patients with psoriasis worldwide.Objective To reach international consensus among psoriasis experts on a uniform dosing regimen for treatment with methotrexate in adult and pediatric patients with psoriasis and identify potential future research topics.Design, Setting, and Participants Between September 2020 and March 2021, a survey study with a modified eDelphi procedure that was developed and distributed by the Amsterdam University Medical Center and completed by 180 participants worldwide (55 [30.6%] resided in non-Western countries) was conducted in 3 rounds. The proposals on which no consensus was reached were discussed in a conference meeting (June 2021). Participants voted on 21 proposals with a 9-point scale (1-3 disagree, 4-6 neither agree nor disagree, 7-9 agree) and were recruited through the Skin Inflammation and Psoriasis International Network and European Academy of Dermatology and Venereology in June 2020. Apart from being a dermatologist/dermatology resident, there were no specific criteria for participation in the survey. The participants worked mainly at a university hospital (97 [53.9%]) and were experienced in treating patients with psoriasis with methotrexate (163 [91.6%] had more than 10 years of experience).Main Outcomes and Measures In a survey with eDelphi procedure, we tried to reach consensus on 21 proposals. Consensus was defined as less than 15% voting disagree (1-3). For the consensus meeting, consensus was defined as less than 30% voting disagree.Results Of 251 participants, 180 (71.7%) completed all 3 survey rounds, and 58 participants (23.1%) joined the conference meeting. Consensus was achieved on 11 proposals in round 1, 3 proposals in round 2, and 2 proposals in round 3. In the consensus meeting, consensus was achieved on 4 proposals. More research is needed, especially for the proposals on folic acid and the dosing of methotrexate for treating subpopulations such as children and vulnerable patients.Conclusions and Relevance In this eDelphi consensus study, consensus was reached on 20 of 21 proposals involving methotrexate dosing in patients with psoriasis. This consensus may potentially be used to harmonize the treatment with methotrexate in patients with psoriasis.

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Av författaren/redakt...: van Huizen, Astr ...; Menting, Stef P.; Gyulai, Rolland; Iversen, Lars; van der Kraaij, ...; Middelkamp-Hup, ...; visa fler...; Warren, Richard ...; Spuls, Phyllis I ...; Schejtman, Adriá ...; Egeberg, Alexand ...; Firooz, Alireza; Kumar, Alur S.; Oakley, Amanda; Foulkes, Amy; Ramos, Andrea Ma ...; Fougerousse, Ann ...; Čarija, Antoanel ...; Akman-Karakaş, A ...; Horváth, Barbara; Fábos, Béata; Matlock, Benjami ...; Claréus, Birgitt ...; Castro, Carla; Ferrándiz, Carlo ...; Correa, Carolina ...; Marchesi, Caroli ...; Goujon, Catherin ...; Gonzalez, Cesar; Maldonado-García ...; Hong, Chih-ho; Griffiths, Chris ...; Vestergaard, Chr ...; Echeverría, Chri ...; de la Cruz, Clau ...; Conrad, Curdin; Törőcsik, Dániel; Drvar, Daniela L ...; Balak, Deepak; Jullien, Denis; Appelen, Diebrec ...; Kim, Dong Hyun; de Jong, Elke M. ...; El Gamal, Emad; Laffitte, Emmanu ...; Mahé, Emmanuel; Sonkoly, Enikö; Colombo, Erika P ...; Vilarrasa, Eva; Willaert, Fabien ...; Novoa, Farah D.; visa färre...

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Artiklar i publikationen: JAMA dermatology

Av lärosätet: Uppsala universitet; Karolinska Institutet

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International eDelphi Study to Reach Consensus on the Methotrexate Dosing Regimen in Patients With Psoriasis

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