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MAIT cell counts ar...
MAIT cell counts are associated with the risk of hospitalization in COPD
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- Pincikova, Terezia (author)
- Uppsala universitet,Lung- allergi- och sömnforskning,Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Pediat, Stockholm, Sweden; Karolinska Inst, Dept Med, Ctr Infect Med, Stockholm, Sweden; Karolinska Univ Hosp Huddinge, Dept Resp Med & Allergy, K85, S-14186 Stockholm, Sweden
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- Parrot, Tiphaine (author)
- Karolinska Inst, Dept Med, Ctr Infect Med, Stockholm, Sweden.
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- Hjelte, Lena (author)
- Karolinska Institutet,Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Pediat, Stockholm, Sweden.;Karolinska Univ Hosp Huddinge, Stockholm CF Ctr, Stockholm, Sweden.
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- Högman, Marieann (author)
- Uppsala universitet,Lung- allergi- och sömnforskning
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- Lisspers, Karin, Docent, 1954- (author)
- Uppsala universitet,Allmänmedicin och preventivmedicin
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- Ställberg, Björn, Docent (author)
- Uppsala universitet,Allmänmedicin och preventivmedicin
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- Janson, Christer (author)
- Uppsala universitet,Lung- allergi- och sömnforskning
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- Malinovschi, Andrei, 1978- (author)
- Uppsala universitet,Klinisk fysiologi
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- Sandberg, Johan K. (author)
- Karolinska Institutet,Karolinska Inst, Dept Med, Ctr Infect Med, Stockholm, Sweden.
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(creator_code:org_t)
- 2022-05-18
- 2022
- English.
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In: Respiratory Research. - : BioMed Central (BMC). - 1465-9921 .- 1465-993X. ; 23:1
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Abstract
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- BackgroundChronic obstructive pulmonary disease (COPD) is characterized by persistent airflow limitation associated with chronic inflammation in the airways. Mucosal-associated invariant T (MAIT) cells are unconventional, innate-like T cells highly abundant in mucosal tissues including the lung. We hypothesized that the characteristics of MAIT cells in circulation may be prospectively associated with COPD morbidity.MethodsCOPD subjects (n = 61) from the Tools for Identifying Exacerbations (TIE) study were recruited when in stable condition. At study entry, forced expiratory volume in 1 s (FEV1) was measured and peripheral blood mononuclear cells were cryopreserved for later analysis by flow cytometry. Patients were followed for 3 years to record clinically meaningful outcomes.ResultsPatients who required hospitalization at one or more occasions during the 3-year follow-up (n = 21) had lower MAIT cell counts in peripheral blood at study inclusion, compared with patients who did not get hospitalized (p = 0.036). In contrast, hospitalized and never hospitalized patients did not differ in CD8 or CD4 T cell counts (p = 0.482 and p = 0.221, respectively). Moreover, MAIT cells in hospitalized subjects showed a more activated phenotype with higher CD38 expression (p = 0.014), and there was a trend towards higher LAG-3 expression (p = 0.052). Conventional CD4 and CD8 T cells were similar between the groups. Next we performed multi-variable logistic regression analysis with hospitalizations as dependent variable, and FEV1, GOLD 2017 group, and quantity or activation of MAIT and conventional T cells as independent variables. MAIT cell count, CD38 expression on MAIT cells, and LAG-3 expression on both MAIT and CD8 T cells were all independently associated with the risk of hospitalization.ConclusionsThese findings suggest that MAIT cells might reflect a novel, FEV1-independent immunological dimension in the complexity of COPD. The potential implication of MAIT cells in COPD pathogenesis and MAIT cells’ prognostic potential deserve further investigation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Keyword
- Human
- COPD
- MAIT cells
- T cells
- Immune activation
Publication and Content Type
- ref (subject category)
- art (subject category)
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Pincikova, Terez ...
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Parrot, Tiphaine
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Hjelte, Lena
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Högman, Marieann
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Lisspers, Karin, ...
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Ställberg, Björn ...
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show more...
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Janson, Christer
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Malinovschi, And ...
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Sandberg, Johan ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Respiratory Medi ...
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Respiratory Rese ...
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Uppsala University
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Karolinska Institutet