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Statistical analysi...
Statistical analysis plan for the randomized controlled trial Tenecteplase in Wake-up Ischaemic Stroke Trial (TWIST)
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- Eltoft, Agnethe (author)
- Univ Hosp North Norway, Dept Neurol, Tromso, Norway.;UiT Arctic Univ Norway, Dept Clin Med, Tromso, Norway.
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- Wilsgaard, Tom (author)
- UiT Arctic Univ Norway, Dept Community Med, Tromso, Norway.
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- Roaldsen, Melinda B. (author)
- UiT Arctic Univ Norway, Dept Clin Med, Tromso, Norway.;Univ Hosp North Norway, Dept Clin Res, Tromso, Norway.
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- Soyland, Mary-Helen (author)
- UiT Arctic Univ Norway, Dept Clin Med, Tromso, Norway.;Sorlandet Hosp Kristiansand, Dept Neurol, Kristiansand, Norway.
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- Lundström, Erik, 1964- (author)
- Uppsala universitet,Neurologi
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- Petersson, Jesper (author)
- Skane Univ Hosp, Dept Neurol, Malmö, Sweden.
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- Indredavik, Bent (author)
- Trondheim Reg & Univ Hosp, St Olavs Hosp, Dept Med, Trondheim, Norway.;Norwegian Univ Sci & Technol, Dept Neuromed & Movement Sci, Trondheim, Norway.
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- Putaala, Jukka (author)
- Helsinki Univ Hosp, Dept Neurol, Helsinki, Finland.;Univ Helsinki, Helsinki, Finland.
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- Christensen, Hanne (author)
- Bispebjerg Hosp, Dept Neurol, Copenhagen, Denmark.;Univ Copenhagen, Copenhagen, Denmark.
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- Korv, Janika (author)
- Univ Tartu, Dept Neurol & Neurosurg, Tartu, Estonia.;Tartu Univ Hosp, Tartu, Estonia.
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- Jatuzis, Dalius (author)
- Vilnius Univ, Dept Neurol & Neurosurg, Ctr Neurol, Vilnius, Lithuania.
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- Engelter, Stefan T. (author)
- Univ Hosp Basel, Dept Neurol, Basel, Switzerland.;Univ Basel, Basel, Switzerland.;Univ Basel, Univ Dept Geriatr Med Felix Platter, Neurol & Neurorehabil, Basel, Switzerland.
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- De Marchis, Gian Marco (author)
- Univ Hosp Basel, Dept Neurol, Basel, Switzerland.;Univ Basel, Basel, Switzerland.
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- Werring, David J. (author)
- UCL Queen Sq Inst Neurol, Stroke Res Ctr, London, England.
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- Robinson, Thompson (author)
- Univ Leicester, Coll Life Sci, Leicester, Leics, England.;Univ Leicester, NIHR Biomed Res Ctr, Leicester, Leics, England.
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- Tveiten, Arnstein (author)
- Sorlandet Hosp Kristiansand, Dept Neurol, Kristiansand, Norway.
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- Mathiesen, Ellisiv B. (author)
- Univ Hosp North Norway, Dept Neurol, Tromso, Norway.;UiT Arctic Univ Norway, Dept Clin Med, Tromso, Norway.
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Univ Hosp North Norway, Dept Neurol, Tromso, Norway;UiT Arctic Univ Norway, Dept Clin Med, Tromso, Norway. UiT Arctic Univ Norway, Dept Community Med, Tromso, Norway. (creator_code:org_t)
- 2022-05-19
- 2022
- English.
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In: Trials. - : Springer Nature. - 1745-6215. ; 23:1
- Related links:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Background: Patients with wake-up ischemic stroke are frequently excluded from thrombolytic treatment due to unknown symptom onset time and limited availability of advanced imaging modalities. The Tenecteplase in Wake-up lschaemic Stroke Trial (TWIST) is a randomized controlled trial of intravenous tenecteplase 0.25 mg/kg and standard care versus standard care alone (no thrombolysis) in patients who wake up with acute ischemic stroke and can be treated within 4.5 h of wakening based on non-contrast CT findings. Objective: To publish the detailed statistical analysis plan for TWIST prior to unblinding. Methods: The TWIST statistical analysis plan is consistent with the Consolidating Standard of Reporting Trials (CON-SORT) statement and provides clear and open reporting. Discussion: Publication of the statistical analysis plan serves to reduce potential trial reporting bias and clearly outlines the pre-specified analyses.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Ischemic stroke
- Thrombolysis
- Wake-up stroke
- Tenecteplase
- TWIST
- Acute stroke therapy
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Eltoft, Agnethe
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Wilsgaard, Tom
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Roaldsen, Melind ...
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Soyland, Mary-He ...
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Lundström, Erik, ...
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Petersson, Jespe ...
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show more...
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Indredavik, Bent
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Putaala, Jukka
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Christensen, Han ...
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Korv, Janika
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Jatuzis, Dalius
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Engelter, Stefan ...
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De Marchis, Gian ...
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Werring, David J ...
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Robinson, Thomps ...
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Tveiten, Arnstei ...
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Mathiesen, Ellis ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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Trials
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Uppsala University