WFRF:(Mansson Ann Sofie)
Search: WFRF:(Mansson Ann Sofie) > FOXO Dictates Initi...
- 2 of 2
- Previous record
- Next record
- To hitlist
FOXO Dictates Initiation of B Cell Development and Myeloid Restriction in Common Lymphoid Progenitors
-
- Pena-Perez, Lucia (author)
- Karolinska Institutet,Karolinska Inst, Ctr Hematol & Regenerat Med, Stockholm, Sweden.;Karolinska Inst, Dept Lab Med, Stockholm, Sweden.
-
- Kharazi, Shabnam (author)
- Karolinska Inst, Ctr Hematol & Regenerat Med, Stockholm, Sweden.;Karolinska Inst, Dept Lab Med, Stockholm, Sweden.
-
- Frengen, Nicolai (author)
- Karolinska Institutet,Karolinska Inst, Ctr Hematol & Regenerat Med, Stockholm, Sweden.;Karolinska Inst, Dept Lab Med, Stockholm, Sweden.
- show more...
- show less...
- Karolinska Institutet Karolinska Inst, Ctr Hematol & Regenerat Med, Stockholm, Sweden;Karolinska Inst, Dept Lab Med, Stockholm, Sweden. (creator_code:org_t)
- 2022-05-04
- 2022
- English.
- In: Frontiers in Immunology. - : Frontiers Media S.A.. - 1664-3224. ; 13
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- The development of B cells relies on an intricate network of transcription factors critical for developmental progression and lineage commitment. In the B cell developmental trajectory, a temporal switch from predominant Foxo3 to Foxo1 expression occurs at the CLP stage. Utilizing VAV-iCre mediated conditional deletion, we found that the loss of FOXO3 impaired B cell development from LMPP down to B cell precursors, while the loss of FOXO1 impaired B cell commitment and resulted in a complete developmental block at the CD25 negative proB cell stage. Strikingly, the combined loss of FOXO1 and FOXO3 resulted in the failure to restrict the myeloid potential of CLPs and the complete loss of the B cell lineage. This is underpinned by the failure to enforce the early B-lineage gene regulatory circuitry upon a predominantly pre-established open chromatin landscape. Altogether, this demonstrates that FOXO3 and FOXO1 cooperatively govern early lineage restriction and initiation of B-lineage commitment in CLPs.
Subject headings
- NATURVETENSKAP -- Biologi -- Utvecklingsbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Developmental Biology (hsv//eng)
Keyword
- B cell
- FOXO (forkhead box protein O)
- lineage commitment
- specification
- myeloid restriction
- gene regulation
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- Frontiers in Immunology (Search for host publication in LIBRIS)
To the university's database
- 2 of 2
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Pena-Perez, Luci ...
- Kharazi, Shabnam
- Frengen, Nicolai
- Krstic, Aleksand ...
- Bouderlique, Thi ...
- Hauenstein, Juli ...
- show more...
- He, Minghui
- Somuncular, Ece
- Li Wang, Xiaoze
- Dahlberg, Carin
- Gustafsson, Char ...
- Johansson, Ann-S ...
- Walfridsson, Jul ...
- Kadri, Nadir
- Woll, Petter
- Kierczak, Marcin ...
- Qian, Hong
- Westerberg, Lisa
- Luc, Sidinh
- Mansson, Robert
- show less...
- About the subject
-
- NATURAL SCIENCES
- NATURAL SCIENCES
- and Biological Scien ...
- and Developmental Bi ...
- Articles in the publication
- Frontiers in Imm ...
- By the university
- Uppsala University
- Karolinska Institutet
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
