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Comprehensive cance...
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Filipowicz, NataliaMed Univ Gdansk, 3P Med Lab, Gdansk, Poland
(author)
Comprehensive cancer-oriented biobanking resource of human samples for studies of post-zygotic genetic variation involved in cancer predisposition
- Article/chapterEnglish2022
Publisher, publication year, extent ...
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2022-04-07
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Public Library of Science (PLoS),2022
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-476808
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-476808URI
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https://doi.org/10.1371/journal.pone.0266111DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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The progress in translational cancer research relies on access to well-characterized samples from a representative number of patients and controls. The rationale behind our biobanking are explorations of post-zygotic pathogenic gene variants, especially in non-tumoral tissue, which might predispose to cancers. The targeted diagnoses are carcinomas of the breast (via mastectomy or breast conserving surgery), colon and rectum, prostate, and urinary bladder (via cystectomy or transurethral resection), exocrine pancreatic carcinoma as well as metastases of colorectal cancer to the liver. The choice was based on the high incidence of these cancers and/or frequent fatal outcome. We also collect age-matched normal controls. Our still ongoing collection originates from five clinical centers and after nearly 2-year cooperation reached 1711 patients and controls, yielding a total of 23226 independent samples, with an average of 74 donors and 1010 samples collected per month. The predominant diagnosis is breast carcinoma, with 933 donors, followed by colorectal carcinoma (383 donors), prostate carcinoma (221 donors), bladder carcinoma (81 donors), exocrine pancreatic carcinoma (15 donors) and metachronous colorectal cancer metastases to liver (14 donors). Forty percent of the total sample count originates from macroscopically healthy cancer-neighboring tissue, while contribution from tumors is 12%, which adds to the uniqueness of our collection for cancer predisposition studies. Moreover, we developed two program packages, enabling registration of patients, clinical data and samples at the participating hospitals as well as the central system of sample/data management at coordinating center. The approach used by us may serve as a model for dispersed biobanking from multiple satellite hospitals. Our biobanking resource ought to stimulate research into genetic mechanisms underlying the development of common cancers. It will allow all available "-omics" approaches on DNA-, RNA-, protein- and tissue levels to be applied. The collected samples can be made available to other research groups.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Drezek, KingaMed Univ Gdansk, 3P Med Lab, Gdansk, Poland
(author)
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Horbacz, MonikaMed Univ Gdansk, 3P Med Lab, Gdansk, Poland
(author)
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Wojdak, AgataMed Univ Gdansk, 3P Med Lab, Gdansk, Poland
(author)
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Szymanowski, JakubMed Univ Gdansk, 3P Med Lab, Gdansk, Poland.;Bioenit Jakub Szymanowski, Gdansk, Poland
(author)
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Rychlicka-Buniowska, EdytaMed Univ Gdansk, 3P Med Lab, Gdansk, Poland
(author)
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Juhas, UlanaMed Univ Gdansk, 3P Med Lab, Gdansk, Poland
(author)
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Duzowska, KatarzynaMed Univ Gdansk, 3P Med Lab, Gdansk, Poland
(author)
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Nowikiewicz, TomaszProf Franciszek Lukaszczyk Mem Hosp, Dept Breast Canc & Reconstruct Surg, Oncol Ctr, Bydgoszcz, Poland.;Nicolaus Copernicus Univ, Ludwik Rydygiers Coll Med, Surg Oncol, Torun, Poland
(author)
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Stankowska, WiktoriaMed Univ Gdansk, 3P Med Lab, Gdansk, Poland
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Chojnowska, KatarzynaMed Univ Gdansk, 3P Med Lab, Gdansk, Poland
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Andreou, MariaMed Univ Gdansk, 3P Med Lab, Gdansk, Poland
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Lawrynowicz, UrszulaMed Univ Gdansk, 3P Med Lab, Gdansk, Poland
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Wojcik, MagdalenaMed Univ Gdansk, 3P Med Lab, Gdansk, Poland
(author)
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Davies, HannaUppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik(Swepub:uu)handa349
(author)
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Srutek, EwaNicolaus Copernicus Univ, Ludwik Rydygiers Coll Med, Surg Oncol, Torun, Poland.;Prof Franciszek Lukaszczyk Mem Hosp, Oncol Ctr, Dept Tumor Pathol & Pathomorphol, Bydgoszcz, Poland
(author)
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Bienkowski, MichalMed Univ Gdansk, Dept Pathomorphol, Gdansk, Poland
(author)
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Milian-Ciesielska, KatarzynaJagiellonian Univ Med Coll, Dept Pathomorphol, Krakow, Poland
(author)
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Zdrenka, MarekProf Franciszek Lukaszczyk Mem Hosp, Oncol Ctr, Dept Tumor Pathol & Pathomorphol, Bydgoszcz, Poland
(author)
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Ambicka, AleksandraMaria Sklodowska Curie Natl Res Inst Oncol, Dept Tumor Pathol, Krakow, Poland
(author)
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Przewoznik, MarcinMaria Sklodowska Curie Natl Res Inst Oncol, Dept Tumor Pathol, Krakow, Poland
(author)
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Harazin-Lechowska, AgnieszkaMaria Sklodowska Curie Natl Res Inst Oncol, Dept Tumor Pathol, Krakow, Poland
(author)
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Adamczyk, AgnieszkaMaria Sklodowska Curie Natl Res Inst Oncol, Dept Tumor Pathol, Krakow, Poland
(author)
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Kowalski, JacekMed Univ Gdansk, Dept Pathomorphol, Gdansk, Poland
(author)
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Bala, DariuszNicolaus Copernicus Univ, Ludwik Rydygiers Coll Med, Surg Oncol, Torun, Poland.;Prof Franciszek Lukaszczyk Mem Hosp, Dept Surg Oncol, Oncol Ctr, Bydgoszcz, Poland
(author)
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Wisniewski, DorianProf Franciszek Lukaszczyk Mem Hosp, Dept Surg Oncol, Oncol Ctr, Bydgoszcz, Poland
(author)
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Tkaczynski, KarolProf Franciszek Lukaszczyk Mem Hosp, Dept Surg Oncol, Oncol Ctr, Bydgoszcz, Poland
(author)
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Kamecki, KrzysztofProf Franciszek Lukaszczyk Mem Hosp, Dept Urol, Oncol Ctr, Bydgoszcz, Poland
(author)
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Drzewiecka, MartaProf Franciszek Lukaszczyk Mem Hosp, Dept Breast Canc & Reconstruct Surg, Oncol Ctr, Bydgoszcz, Poland
(author)
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Wronski, PawelProf Franciszek Lukaszczyk Mem Hosp, Dept Urol, Oncol Ctr, Bydgoszcz, Poland
(author)
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Siekiera, JerzyProf Franciszek Lukaszczyk Mem Hosp, Dept Urol, Oncol Ctr, Bydgoszcz, Poland
(author)
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Ratnicka, IzabelaMed Univ Gdansk, Dept Plast Surg, Gdansk, Poland
(author)
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Jankau, JerzyMed Univ Gdansk, Dept Plast Surg, Gdansk, Poland
(author)
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Wierzba, KarolMed Univ Gdansk, Dept Internal Med Connect Tissue Dis & Geriatr, Gdansk, Poland
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Skokowski, JaroslawMed Univ Gdansk, Dept Surg Oncol, Gdansk, Poland.;Med Univ Gdansk, Dept Med Lab Diagnost Biobank, Gdansk, Poland
(author)
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Polom, KarolMed Univ Gdansk, Dept Surg Oncol, Gdansk, Poland
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Przydacz, MikolajJagiellonian Univ Med Coll, Dept Urol, Krakow, Poland
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Belch, LukaszJagiellonian Univ Med Coll, Dept Urol, Krakow, Poland
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Chlosta, PiotrJagiellonian Univ Med Coll, Dept Urol, Krakow, Poland
(author)
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Matuszewski, MarcinMed Univ Gdansk, Dept & Clin Urol, Gdansk, Poland
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Okon, KrzysztofJagiellonian Univ Med Coll, Dept Pathomorphol, Krakow, Poland
(author)
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Rostkowska, OlgaMed Univ Gdansk, Dept Gen Endocrine & Transplant Surg, Gdansk, Poland
(author)
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Hellmann, AndrzejMed Univ Gdansk, Dept Gen Endocrine & Transplant Surg, Gdansk, Poland
(author)
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Sasim, KarolSpecialist Hosp Koscierzyna, Clin Urol & Oncol Urol, Koscierzyna, Poland
(author)
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Remiszewski, PiotrMed Univ Gdansk, Dept Gen Endocrine & Transplant Surg, Gdansk, Poland
(author)
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Sierzega, MarekJagiellonian Univ Med Coll, Dept Gen Oncol & Gastrointestinal Surg, Krakow, Poland
(author)
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Hac, StanislawMed Univ Gdansk, Dept Gen Endocrine & Transplant Surg, Gdansk, Poland
(author)
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Kobiela, JaroslawMed Univ Gdansk, Dept Gen Endocrine & Transplant Surg, Gdansk, Poland
(author)
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Kaska, LukaszMed Univ Gdansk, Dept Gen Endocrine & Transplant Surg, Gdansk, Poland
(author)
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Jankowski, MichalNicolaus Copernicus Univ, Ludwik Rydygiers Coll Med, Surg Oncol, Torun, Poland.;Prof Franciszek Lukaszczyk Mem Hosp, Dept Surg Oncol, Oncol Ctr, Bydgoszcz, Poland
(author)
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Hodorowicz-Zaniewska, DianaJagiellonian Univ Med Coll, Dept Gen Oncol & Gastrointestinal Surg, Krakow, Poland
(author)
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Jaszczynski, JanuszMaria Sklodowska Curie Natl Res Inst Oncol, Dept Urol, Krakow, Poland
(author)
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Zegarski, WojciechNicolaus Copernicus Univ, Ludwik Rydygiers Coll Med, Surg Oncol, Torun, Poland.;Prof Franciszek Lukaszczyk Mem Hosp, Dept Surg Oncol, Oncol Ctr, Bydgoszcz, Poland
(author)
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Makarewicz, WojciechMed Univ Gdansk, Dept Surg Oncol, Gdansk, Poland.;Specialist Hosp Koscierzyna, Clin Gen & Oncol Surg, Koscierzyna, Poland
(author)
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Peksa, RafalMed Univ Gdansk, Dept Pathomorphol, Gdansk, Poland
(author)
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Szpor, JoannaJagiellonian Univ Med Coll, Dept Pathomorphol, Krakow, Poland
(author)
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Rys, JanuszMaria Sklodowska Curie Natl Res Inst Oncol, Dept Tumor Pathol, Krakow, Poland
(author)
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Szylberg, LukaszProf Franciszek Lukaszczyk Mem Hosp, Oncol Ctr, Dept Tumor Pathol & Pathomorphol, Bydgoszcz, Poland.;Nicolaus Copernicus Univ, Dept Clin Pathomorphol, Coll Med Bydgoszcz, Torun, Poland
(author)
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Piotrowski, ArkadiuszMed Univ Gdansk, 3P Med Lab, Gdansk, Poland.;Med Univ Gdansk, Dept Biol & Pharmaceut Bot, Gdansk, Poland
(author)
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Dumanski, Jan P.Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik,Med Univ Gdansk, 3P Med Lab, Gdansk, Poland.;Med Univ Gdansk, Dept Biol & Pharmaceut Bot, Gdansk, Poland(Swepub:uu)janduman
(author)
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Med Univ Gdansk, 3P Med Lab, Gdansk, PolandMed Univ Gdansk, 3P Med Lab, Gdansk, Poland.;Bioenit Jakub Szymanowski, Gdansk, Poland
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In:PLOS ONE: Public Library of Science (PLoS)17:41932-6203
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Filipowicz, Nata ...
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Drezek, Kinga
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Horbacz, Monika
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Wojdak, Agata
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Szymanowski, Jak ...
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Rychlicka-Buniow ...
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Juhas, Ulana
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Duzowska, Katarz ...
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Nowikiewicz, Tom ...
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Stankowska, Wikt ...
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Chojnowska, Kata ...
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Andreou, Maria
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Lawrynowicz, Urs ...
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Wojcik, Magdalen ...
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Davies, Hanna
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Srutek, Ewa
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Bienkowski, Mich ...
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Milian-Ciesielsk ...
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Zdrenka, Marek
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Ambicka, Aleksan ...
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Harazin-Lechowsk ...
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Adamczyk, Agnies ...
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Kowalski, Jacek
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Bala, Dariusz
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Wisniewski, Dori ...
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Tkaczynski, Karo ...
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Kamecki, Krzyszt ...
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Drzewiecka, Mart ...
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Wronski, Pawel
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Siekiera, Jerzy
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Ratnicka, Izabel ...
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Jankau, Jerzy
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Wierzba, Karol
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Skokowski, Jaros ...
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Polom, Karol
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Przydacz, Mikola ...
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Belch, Lukasz
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Chlosta, Piotr
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Matuszewski, Mar ...
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Okon, Krzysztof
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Rostkowska, Olga
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Hellmann, Andrze ...
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Sasim, Karol
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Remiszewski, Pio ...
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Sierzega, Marek
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Hac, Stanislaw
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Kobiela, Jarosla ...
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Kaska, Lukasz
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Jankowski, Micha ...
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Hodorowicz-Zanie ...
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Jaszczynski, Jan ...
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Zegarski, Wojcie ...
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Makarewicz, Wojc ...
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Peksa, Rafal
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Szpor, Joanna
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Rys, Janusz
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Szylberg, Lukasz
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Piotrowski, Arka ...
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