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Responsible innovat...
Responsible innovation in human germline gene editing. Background document to the recommendations of ESHG and ESHRE
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- de Wert, Guido (författare)
- Maastricht Univ, Dept Hlth Eth & Soc, Res Inst GROW & CAPHRI, Fac Hlth Med & Life Sci, POB 616, NL-6200 MD Maastricht, Netherlands.
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- Heindryckx, Bjoern (författare)
- Ghent Univ Hosp, Dept Reprod Med, Ghent Fertil & Stem Cell Team G FaST, C Heymanslaan 10, B-9000 Ghent, Belgium.
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- Pennings, Guido (författare)
- Univ Ghent, Bioeth Inst Ghent, Dept Philosophy & Moral Sci, Blandijnberg 2, B-9000 Ghent, Belgium.
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- Clarke, Angus (författare)
- Univ Hosp Wales, Inst Med Genet, Heath Pk, Cardiff CF14 4XN, Wales.
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- Eichenlaub-Ritter, Ursula (författare)
- Univ Bielefeld, Inst Gene Technol Microbiol, Fac Biol, Postfach 10 01 31, D-33501 Bielefeld, Germany.
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- van El, Carla G. (författare)
- Vrije Univ Amsterdam Med Ctr, Sect Community Genet, Dept Clin Genet, Van der Boechorststr 7, NL-1081 BT Amsterdam, Netherlands.;Vrije Univ Amsterdam Med Ctr, Amsterdam Publ Hlth Res Inst, Van der Boechorststr 7, NL-1081 BT Amsterdam, Netherlands.
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- Forzano, Francesca (författare)
- Guys & St Thomas NHS Fdn Trust, Clin Genet Dept, Guys Hosp, 7th Floor Borough Wing, London SE1 9RT, England.
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- Goddijn, Mariette (författare)
- Acad Med Ctr, Dept Obstet & Gynecol, Ctr Reprod Med, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands.
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- Howard, Heidi Carmen (författare)
- Uppsala universitet,Centrum för forsknings- och bioetik
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- Radojkovic, Dragica (författare)
- Univ Belgrade, Inst Mol Genet & Genet Engn, Lab Mol Biol, POB 23, Belgrade 11010, Serbia.
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- Rial-Sebbag, Emmanuelle (författare)
- Univ Toulouse Univ Paul Sabatier Toulouse III, INSERM, UMR 1027, Allees Jules Guesdes 37, F-31073 Toulouse, France.
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- Dondorp, Wybo (författare)
- Maastricht Univ, Dept Hlth Eth & Soc, Res Inst GROW & CAPHRI, Fac Hlth Med & Life Sci, POB 616, NL-6200 MD Maastricht, Netherlands.
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- Tarlatzis, Basil C. (författare)
- Aristotle Univ Thessaloniki, Dept Obstet & Gynecol 1, Sch Med, 9 Agias Sofias Str, Thessaloniki 54623, Greece.
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- Cornel, Martina C. (författare)
- Vrije Univ Amsterdam Med Ctr, Sect Community Genet, Dept Clin Genet, Van der Boechorststr 7, NL-1081 BT Amsterdam, Netherlands.;Vrije Univ Amsterdam Med Ctr, Amsterdam Publ Hlth Res Inst, Van der Boechorststr 7, NL-1081 BT Amsterdam, Netherlands.
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Maastricht Univ, Dept Hlth Eth & Soc, Res Inst GROW & CAPHRI, Fac Hlth Med & Life Sci, POB 616, NL-6200 MD Maastricht, Netherlands Ghent Univ Hosp, Dept Reprod Med, Ghent Fertil & Stem Cell Team G FaST, C Heymanslaan 10, B-9000 Ghent, Belgium. (creator_code:org_t)
- 2018-01-12
- 2018
- Engelska.
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Ingår i: HUMAN REPRODUCTION OPEN. - : Oxford University Press (OUP). - 2399-3529. ; 2018:1
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Technological developments in gene editing raise high expectations for clinical applications, including editing of the germline. The European Society of Human Reproduction and Embryology (ESHRE) and the European Society of Human Genetics (ESHG) together developed a Background document and Recommendations to inform and stimulate ongoing societal debates. This document provides the background to the Recommendations. Germline gene editing is currently not allowed in many countries. This makes clinical applications in these countries impossible now, even if germline gene editing would become safe and effective. What were the arguments behind this legislation, and are they still convincing? If a technique could help to avoid serious genetic disorders, in a safe and effective way, would this be a reason to reconsider earlier standpoints? This Background document summarizes the scientific developments and expectations regarding germline gene editing, legal regulations at the European level, and ethics for three different settings (basic research, pre-clinical research and clinical applications). In ethical terms, we argue that the deontological objections (e.g. gene editing goes against nature) do not seem convincing while consequentialist objections (e.g. safety for the children thus conceived and following generations) require research, not all of which is allowed in the current legal situation in European countries. Development of this Background document and Recommendations reflects the responsibility to help society understand and debate the full range of possible implications of the new technologies, and to contribute to regulations that are adapted to the dynamics of the field while taking account of ethical considerations and societal concerns.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Medicinsk etik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Medical Ethics (hsv//eng)
Nyckelord
- germline gene editing
- human germline gene editing
- ESHRE
- ESHG
- ethics
- legislation
- responsible innovation
- professional policy
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de Wert, Guido
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Heindryckx, Bjoe ...
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Pennings, Guido
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Clarke, Angus
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Eichenlaub-Ritte ...
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van El, Carla G.
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Forzano, Frances ...
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Goddijn, Mariett ...
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Howard, Heidi Ca ...
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Radojkovic, Drag ...
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Rial-Sebbag, Emm ...
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Dondorp, Wybo
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Tarlatzis, Basil ...
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Cornel, Martina ...
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