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HLA-DQ heterodimers...
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Petersdorf, Effie W.Fred Hutchinson Canc Res Ctr, Div Clin Res, 1124 Columbia St, Seattle, WA 98104 USA.;Univ Washington, Dept Med, Seattle, WA USA.
(författare)
HLA-DQ heterodimers in hematopoietic cell transplantation
- Artikel/kapitelEngelska2022
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American Society of Hematology,2022
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Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-477766
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-477766URI
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https://doi.org/10.1182/blood.2022015860DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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HLA-DQ heterodimers increase the susceptibility to autoimmune diseases, but their role in hematopoietic cell transplantation is unknown. We tested the hypothesis that outcome after HLA-matched and HLA-DQ-mismatched hematopoietic cell transplantation is influenced by HLA-DQ heterodimers. Heterodimers were defined in 5164 HLA-matched and 520 HLA-DQ-mismatched patients and their transplant donors according to well-established crystallographic criteria. Group 1 (G1) heterodimers are any DQA1*02/03/04/05/06a paired with any DQB1*02/03/040. Group 2 (G2) heterodimers are DQA1*01a paired with any DQB1*05/060. Multivariable models identified significantly higher relapse risk in G1G2 and G2G2 compared with G1G1 HLA-matched patients with malignant disease; risk increased with an increasing number of G2 molecules. In HLA-DQ-mismatched transplantation for malignant diseases, matching or mismatching for G2 increased relapse risk. G2 lowered disease-free survival after both HLA-matched and HLA-DQ-mismatched transplantation. A paradigm based on HLA-DQ heterodimers provides a functional definition of the hematopoietic cell transplantation barrier and a means to lower risks for future patients.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Bengtsson, MatsUppsala universitet,Klinisk immunologi(Swepub:uu)matsbs
(författare)
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Horowitz, MaryCtr Int Blood & Marrow Transplant Res, Milwaukee, WI USA.;Med Coll Wisconsin, Div Hematol & Oncol, Milwaukee, WI 53226 USA.
(författare)
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McKallor, CarolineFred Hutchinson Canc Res Ctr, Div Clin Res, 1124 Columbia St, Seattle, WA 98104 USA.
(författare)
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Spellman, Stephen R.Ctr Int Blood & Marrow Transplant Res, Minneapolis, MN USA.
(författare)
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Spierings, EricMatchis Fdn, Leiden, Netherlands.;Univ Med Ctr Utrecht, Utrecht, Netherlands.
(författare)
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Gooley, Ted A.Fred Hutchinson Canc Res Ctr, Div Clin Res, 1124 Columbia St, Seattle, WA 98104 USA.
(författare)
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Stevenson, PhilFred Hutchinson Canc Res Ctr, Div Clin Res, 1124 Columbia St, Seattle, WA 98104 USA.
(författare)
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Fred Hutchinson Canc Res Ctr, Div Clin Res, 1124 Columbia St, Seattle, WA 98104 USA.;Univ Washington, Dept Med, Seattle, WA USA.Klinisk immunologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Blood: American Society of Hematology139:20, s. 3009-30170006-49711528-0020
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