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  • Shang, PeiMayo Clin, Dept Mol Pharmacol & Expt Therapeut, Coll Med & Sci, Rochester, MN 55905 USA.;First Hosp Jilin Univ, Dept Neurol, Changchun, Peoples R China. (author)

Identification of cerebrospinal fluid and serum metabolomic biomarkers in first episode psychosis patients

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2022-06-03
  • Springer Nature,2022
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-477778
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-477778URI
  • https://doi.org/10.1038/s41398-022-02000-1DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:149760032URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Psychotic disorders are currently diagnosed by examining the patient's mental state and medical history. Identifying reliable diagnostic, monitoring, predictive, or prognostic biomarkers would be useful in clinical settings and help to understand the pathophysiology of schizophrenia. Here, we performed an untargeted metabolomics analysis using ultra-high pressure liquid chromatography coupled with time-of-flight mass spectroscopy on cerebrospinal fluid (CSF) and serum samples of 25 patients at their first-episode psychosis (FEP) manifestation (baseline) and after 18 months (follow-up). CSF and serum samples of 21 healthy control (HC) subjects were also analyzed. By comparing FEP and HC groups at baseline, we found eight CSF and 32 serum psychosis-associated metabolites with non-redundant identifications. Most remarkable was the finding of increased CSF serotonin (5-HT) levels. Most metabolites identified at baseline did not differ between groups at 18-month follow-up with significant improvement of positive symptoms and cognitive functions. Comparing FEP patients at baseline and 18-month follow-up, we identified 20 CSF metabolites and 90 serum metabolites that changed at follow-up. We further utilized Ingenuity Pathway Analysis (IPA) and identified candidate signaling pathways involved in psychosis pathogenesis and progression. In an extended cohort, we validated that CSF 5-HT levels were higher in FEP patients than in HC at baseline by reversed-phase high-pressure liquid chromatography. To conclude, these findings provide insights into the pathophysiology of psychosis and identify potential psychosis-associated biomarkers.

Subject headings and genre

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  • Ho, Ada Man-ChoiMayo Clin, Dept Psychiat & Psychol, Coll Med & Sci, Rochester, MN 55905 USA. (author)
  • Tufvesson-Alm, MaximilianKarolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden. (author)
  • Lindberg, Daniel R.Mayo Clin, Sch Med & Sci, Mayo Clin MD PhD Program, Rochester, MN USA.;Mayo Clin, Neurosci Program, Coll Med & Sci, Rochester, MN 55905 USA. (author)
  • Grant, Caroline W.Mayo Clin, Dept Mol Pharmacol & Expt Therapeut, Coll Med & Sci, Rochester, MN 55905 USA. (author)
  • Orhan, FundaKarolinska Institutet (author)
  • Eren, FerideKarolinska Institutet (author)
  • Bhat, MariaAstraZeneca, Sci Life Lab, Res & Dev Innovat Med Personalised Healthcare & B, SE-17177 Solna, Sweden. (author)
  • Engberg, GoranKarolinska Institutet (author)
  • Schwieler, LillyKarolinska Institutet (author)
  • Fatouros-Bergman, HelenaKarolinska Institutet (author)
  • Imbeault, SophieKarolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden. (author)
  • Iverson, Ryan M.Mayo Clin, Div Biomed Stat & Informat, Coll Med, Rochester, MN USA. (author)
  • Dasari, SurendraMayo Clin, Div Biomed Stat & Informat, Coll Med, Rochester, MN USA. (author)
  • Piehl, FredrikKarolinska Univ Hosp, Ctr Mol Med, Karolinska Inst, Dept Clin Neurosci,Unit Neuroimmunol, Stockholm, Sweden. (author)
  • Cervenka, SimonKarolinska Institutet,Uppsala universitet,Psykiatri,Karolinska Inst, Ctr Psychiat Res, Dept Clin Neurosci, Stockholm, Sweden.;Reg Stockholm, Stockholm Hlth Care Serv, Stockholm, Sweden.(Swepub:uu)simce160 (author)
  • Sellgren, Carl M.Karolinska Institutet (author)
  • Erhardt, SophieKarolinska Institutet (author)
  • Choi, Doo-SupMayo Clin, Dept Mol Pharmacol & Expt Therapeut, Coll Med & Sci, Rochester, MN 55905 USA.;Mayo Clin, Dept Psychiat & Psychol, Coll Med & Sci, Rochester, MN 55905 USA.;Mayo Clin, Neurosci Program, Coll Med & Sci, Rochester, MN 55905 USA. (author)
  • Mayo Clin, Dept Mol Pharmacol & Expt Therapeut, Coll Med & Sci, Rochester, MN 55905 USA.;First Hosp Jilin Univ, Dept Neurol, Changchun, Peoples R China.Mayo Clin, Dept Psychiat & Psychol, Coll Med & Sci, Rochester, MN 55905 USA. (creator_code:org_t)

Related titles

  • In:Translational Psychiatry: Springer Nature12:12158-3188

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