Sökning: WFRF:(Husebye Eystein Sverre) >
Premature menopause...
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Vogt, Elinor ChelsomDepartment of Clinical Science, University of Bergen, Bergen, Norway; K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway; Department of Medicine, Haukeland University Hospital, Bergen, Norway
(författare)
Premature menopause and autoimmune primary ovarian insufficiency in two international multi-center cohorts
- Artikel/kapitelEngelska2022
Förlag, utgivningsår, omfång ...
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Bioscientifica,2022
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-478260
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-478260URI
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https://doi.org/10.1530/EC-22-0024DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-196823URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:150575614URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Objective: To investigate markers of premature menopause (<40 years) and specifically the prevalence of autoimmune primary ovarian insufficiency (POI) in European women.Design: Postmenopausal women were categorized according to age at menopause and self-reported reason for menopause in a cross-sectional analysis of 6870 women.Methods: Variables associated with the timing of menopause and hormone measurements of 17β-estradiol and follicle-stimulating hormone were explored using multivariable logistic regression analysis. Specific immunoprecipitating assays of steroidogenic autoantibodies against 21-hydroxylase (21-OH), side-chain cleavage enzyme (anti-SCC) and 17alpha-hydroxylase (17 OH), as well as NACHT leucine-rich-repeat protein 5 were used to identify women with likely autoimmune POI.Results: Premature menopause was identified in 2.8% of women, and these women had higher frequencies of nulliparity (37.4% vs 19.7%), obesity (28.7% vs 21.4%), osteoporosis (17.1% vs 11.6%), hormone replacement therapy (59.1% vs 36.9%) and never smokers (60.1% vs 50.9%) (P < 0.05), compared to women with menopause ≥40 years. Iatrogenic causes were found in 91 (47%) and non-ovarian causes in 27 (14%) women, while 77 (39%) women were classified as POI of unknown cause, resulting in a 1.1% prevalence of idiopathic POI. After adjustments nulliparity was the only variable significantly associated with POI (odds ratio 2.46; 95% CI 1.63-3.42). Based on the presence of autoantibodies against 21 OH and SCC, 4.5% of POI cases were of likely autoimmune origin.Conclusion: Idiopathic POI affects 1.1% of all women and almost half of the women with premature menopause. Autoimmunity explains 4.5% of these cases judged by positive steroidogenic autoantibodies.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Real, Francisco GómezDepartment of Clinical Science, University of Bergen, Bergen, Norway; Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway
(författare)
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Husebye, Eystein SverreDepartment of Clinical Science, University of Bergen, Bergen, Norway; K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway; Department of Medicine, Haukeland University Hospital, Bergen, Norway
(författare)
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Björnsdottir, SigridurKarolinska Institutet
(författare)
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Benediktsdottir, BryndisMedical Faculty, University of Iceland, Reykjavik, Iceland; Department of Sleep, Landspitali University Hospital Reykjavík, Reykjavik, Iceland
(författare)
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Bertelsen, Randi JacobsenDepartment of Clinical Science, University of Bergen, Bergen, Norway
(författare)
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Demoly, PascalUniversity Hospital of Montpellier, IDESP, Univ Montpellier-Inserm, Montpellier, France
(författare)
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Franklin, Karl AndersUmeå universitet,Kirurgi(Swepub:umu)kafr0021
(författare)
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de Aja Gallastegui, Leire SainzUnit of Epidemiology and Public Health, Department of Health, Basque Government, Vitoria-Gasteiz, Spain
(författare)
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González, Francisco Javier CallejasDepartment of Respiratory Medicine, Albacete University Hospital, Albacete, Spain
(författare)
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Heinrich, JoachimInstitute and Clinic for Occupational, Social and Environmental Medicine, University Hospital, LMU Munich, Munich, Germany; Allergy and Lung Health Unit, Melbourne School of Population and Global Health, The University of Melbourne, VIC, Melbourne, Australia
(författare)
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Holm, MathiasOccupational and Environmental Medicine, School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
(författare)
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Jogi, Nils OscarDepartment of Clinical Science, University of Bergen, Bergen, Norway
(författare)
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Leynaert, BenedicteUniversité Paris-Saclay, Inserm U1018, Center for Epidemiology and Population Health, Integrative Respiratory Epidemiology Team, Villejuif, France
(författare)
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Lindberg, EvaUppsala universitet,Lung- allergi- och sömnforskning,Department of Medical Sciences, Respiratory, Allergy and Sleep Medicine, Uppsala University, Uppsala, Sweden(Swepub:uu)evalb
(författare)
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Malinovschi, Andrei,1978-Uppsala universitet,Klinisk fysiologi,Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden(Swepub:uu)anmal535
(författare)
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Martínez-Moratalla, JesúsPneumology Service of the General University Hospital of Albacete, Albacete, Spain; Albacete Faculty of Medicine, Castilla-La Mancha University, Albacete, Spain
(författare)
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Mayoral, Raúl GodoyDepartment of Respiratory Medicine, Albacete University Hospital, Albacete, Spain
(författare)
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Oudin, AnnaUmeå universitet,Avdelningen för hållbar hälsa(Swepub:umu)anou0004
(författare)
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Pereira-Vega, AntonioJuan Ramón Jiménez University Hospital in Huelva, Huelva, Spain
(författare)
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Semjen, Chantal RaherisonINSERM, EpiCene Team U1219, University of Bordeaux, Talence, France
(författare)
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Schlünssen, ViviDepartment of Public Health, Environment, Work and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark; The National Research Center for the Working Environment, Copenhagen, Denmark
(författare)
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Triebner, KaiDepartment of Clinical Science, University of Bergen, Bergen, Norway
(författare)
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Øksnes, MarianneDepartment of Clinical Science, University of Bergen, Bergen, Norway; K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway; Department of Medicine, Haukeland University Hospital, Bergen, Norway
(författare)
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Department of Clinical Science, University of Bergen, Bergen, Norway; K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway; Department of Medicine, Haukeland University Hospital, Bergen, NorwayDepartment of Clinical Science, University of Bergen, Bergen, Norway; Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Endocrine Connections: Bioscientifica11:52049-3614
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Vogt, Elinor Che ...
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Real, Francisco ...
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Husebye, Eystein ...
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Björnsdottir, Si ...
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Benediktsdottir, ...
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Bertelsen, Randi ...
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visa fler...
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Demoly, Pascal
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Franklin, Karl A ...
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de Aja Gallasteg ...
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González, Franci ...
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Heinrich, Joachi ...
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Holm, Mathias
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Jogi, Nils Oscar
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Leynaert, Benedi ...
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Lindberg, Eva
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Malinovschi, And ...
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Martínez-Moratal ...
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Mayoral, Raúl Go ...
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Oudin, Anna
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Pereira-Vega, An ...
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Semjen, Chantal ...
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Schlünssen, Vivi
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Triebner, Kai
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Øksnes, Marianne
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MEDICIN OCH HÄLS ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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