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Search: WFRF:(Heindel Jerrold J.) > Obesity II :

  • Heindel, Jerrold J.Hlth Environm & Endocrine Disruptor Strategies, Commonweal, Bolinas, CA 92924 USA. (author)

Obesity II : Establishing causal links between chemical exposures and obesity

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • Elsevier,2022
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-478863
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-478863URI
  • https://doi.org/10.1016/j.bcp.2022.115015DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:149780096URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:for swepub-publicationtype

Notes

  • Obesity is a multifactorial disease with both genetic and environmental components. The prevailing view is that obesity results from an imbalance between energy intake and expenditure caused by overeating and insufficient exercise. We describe another environmental element that can alter the balance between energy intake and energy expenditure: obesogens. Obesogens are a subset of environmental chemicals that act as endocrine disruptors affecting metabolic endpoints. The obesogen hypothesis posits that exposure to endocrine disruptors and other chemicals can alter the development and function of the adipose tissue, liver, pancreas, gastrointestinal tract, and brain, thus changing the set point for control of metabolism. Obesogens can determine how much food is needed to maintain homeostasis and thereby increase the susceptibility to obesity. The most sensitive time for obesogen action is in utero and early childhood, in part via epigenetic programming that can be transmitted to future generations. This review explores the evidence supporting the obesogen hypothesis and highlights knowledge gaps that have prevented widespread acceptance as a contributor to the obesity pandemic. Critically, the obesogen hypothesis changes the narrative from curing obesity to preventing obesity.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Howard, SarahHlth Environm & Endocrine Disruptor Strategies, Commonweal, Bolinas, CA 92924 USA. (author)
  • Agay-Shay, KerenUniv Paris, Dept Syst Biol & Bioinformat, INSERM, T3S, Paris, France. (author)
  • Arrebola, Juan P.Univ Bordeaux, Dept Life & Hlth Sci, INSERM, Pessac, France. (author)
  • Audouze, KarineUniv Paris, Dept Biochem, INSERM, T3S, F-75006 Paris, France. (author)
  • Babin, Patrick J.Univ Louisville, Div Gastroenterol Hepatol & Nutr, Louisville, KY 40402 USA. (author)
  • Barouki, RobertUniv South Carolina, Environm Hlth & Dis Lab, Columbia, SC 29208 USA. (author)
  • Bansal, AmitaUniv Cote Azur, Obstet & Gynecol, Cote Azur, France. (author)
  • Blanc, EtienneUniv South Carolina, Environm Hlth & Dis Lab, Columbia, SC 29208 USA. (author)
  • Cave, Matthew C.Texas A&M Univ, Coll Pharm, College Stn, TX 77843 USA. (author)
  • Chatterjee, SaurabhUniv Bari Aldo Moro, Dept Endocrinol, Bari, Italy. (author)
  • Chevalier, NicolasEast Carolina Univ, Brody Sch Med, Greenville, NC 27834 USA. (author)
  • Choudhury, MahuaQueens Univ, Inst Global Food Secur, Sch Biol Sci, Belfast, North Ireland. (author)
  • Collier, DavidUniv Stirling, Occupat & Environm Hlth Res Grp, Stirling, Scotland. (author)
  • Connolly, LisaBar Ilan Univ, Azrieli Fac Med, Hlth & Environm Res HER Lab, Ramat Gan, Israel. (author)
  • Coumoul, Xavier (author)
  • Garruti, GabriellaPubl Hlth Univ Granada, Dept Prevent Med, Granada, Spain. (author)
  • Gilbertson, MichaelAustralian Natl Univ, Coll Hlth & Med, Canberra, Australia. (author)
  • Hoepner, Lori A.SUNY Downstate Hlth Sci Univ, Sch Publ Hlth, Dept Environm & Occupat Hlth Sci, Brooklyn, NY 11203 USA. (author)
  • Holloway, Alison C.McMaster Univ, Dept Obstet & Gynecol, Ontario, CA USA. (author)
  • Howell Iii, GeorgeUniv Louisville, Div Gastroenterol Hepatol & Nutr, Louisville, KY 40402 USA.;Univ Cote Azur, Obstet & Gynecol, Cote Azur, France.;Mississippi State Univ, Ctr Environm Hlth Sci, Starkville, MS 39762 USA. (author)
  • Kassotis, Christopher D.Univ Louisville, Div Gastroenterol Hepatol & Nutr, Louisville, KY 40402 USA.;Univ Cote Azur, Obstet & Gynecol, Cote Azur, France.;Wayne State Univ, Inst Environm Hlth Sci, Dept Pharmacol, Detroit, MI 48202 USA. (author)
  • Kay, Mathew K.Univ Louisville, Div Gastroenterol Hepatol & Nutr, Louisville, KY 40402 USA.;Univ Cote Azur, Obstet & Gynecol, Cote Azur, France. (author)
  • Kim, Min JiUniv Louisville, Div Gastroenterol Hepatol & Nutr, Louisville, KY 40402 USA.;Univ Cote Azur, Obstet & Gynecol, Cote Azur, France.;Sorbonne Paris Nord Univ, INSERM U1124 (T3S), Bobigny, Paris, France. (author)
  • Lagadic-Gossmann, DominiqueUniv Paris, Dept Biochem, INSERM, T3S, F-75006 Paris, France.;Univ Louisville, Div Gastroenterol Hepatol & Nutr, Louisville, KY 40402 USA.;Univ Cote Azur, Obstet & Gynecol, Cote Azur, France.;Univ Rennes, INSERM EHESP, IRSET UMR 5S 1085, F-35000 Rennes, France. (author)
  • Langouet, SophieUniv Paris, Dept Biochem, INSERM, T3S, F-75006 Paris, France.;Univ Louisville, Div Gastroenterol Hepatol & Nutr, Louisville, KY 40402 USA.;Univ Cote Azur, Obstet & Gynecol, Cote Azur, France.;Univ Rennes, INSERM EHESP, IRSET UMR 5S 1085, F-35000 Rennes, France. (author)
  • Legrand, AntoineUniv Louisville, Div Gastroenterol Hepatol & Nutr, Louisville, KY 40402 USA.;Univ Cote Azur, Obstet & Gynecol, Cote Azur, France. (author)
  • Li, ZhuoruiUniv Louisville, Div Gastroenterol Hepatol & Nutr, Louisville, KY 40402 USA.;Univ Cote Azur, Obstet & Gynecol, Cote Azur, France.;Univ Calif Irvine, Dept Dev & Cell Biol, Irvine, CA 92697 USA. (author)
  • Le Mentec, HeleneUniv Louisville, Div Gastroenterol Hepatol & Nutr, Louisville, KY 40402 USA.;Univ Cote Azur, Obstet & Gynecol, Cote Azur, France. (author)
  • Lind, LarsUppsala universitet,Klinisk epidemiologi,Univ Louisville, Div Gastroenterol Hepatol & Nutr, Louisville, KY 40402 USA.;Univ Cote Azur, Obstet & Gynecol, Cote Azur, France.(Swepub:uu)larslind (author)
  • Lind, P. Monica,1957-Uppsala universitet,Arbets- och miljömedicin,Univ Louisville, Div Gastroenterol Hepatol & Nutr, Louisville, KY 40402 USA.;Univ Cote Azur, Obstet & Gynecol, Cote Azur, France.(Swepub:uu)monilind (author)
  • Lustig, Robert H.Univ Louisville, Div Gastroenterol Hepatol & Nutr, Louisville, KY 40402 USA.;Univ Cote Azur, Obstet & Gynecol, Cote Azur, France.;Univ Calif San Francisco, Dept Pediat, Div Endocrinol, San Francisco, CA 94143 USA. (author)
  • Martin-Chouly, CorinneUniv Louisville, Div Gastroenterol Hepatol & Nutr, Louisville, KY 40402 USA.;Univ Cote Azur, Obstet & Gynecol, Cote Azur, France. (author)
  • Kos, Vesna MunicKarolinska Institutet,Univ Louisville, Div Gastroenterol Hepatol & Nutr, Louisville, KY 40402 USA.;Univ Cote Azur, Obstet & Gynecol, Cote Azur, France.;Karolinska Inst, Dept Physiol & Pharmacol, Solna, Sweden. (author)
  • Podechard, NormandUniv Louisville, Div Gastroenterol Hepatol & Nutr, Louisville, KY 40402 USA.;Univ Cote Azur, Obstet & Gynecol, Cote Azur, France. (author)
  • Roepke, Troy A.Univ Louisville, Div Gastroenterol Hepatol & Nutr, Louisville, KY 40402 USA.;Univ Cote Azur, Obstet & Gynecol, Cote Azur, France.;Rutgers State Univ, Sch Environm & Biol Sci, Dept Anim Sci, New Brunswick, NJ 08901 USA. (author)
  • Sargis, RobertM.Univ Louisville, Div Gastroenterol Hepatol & Nutr, Louisville, KY 40402 USA.;Univ Cote Azur, Obstet & Gynecol, Cote Azur, France.;Univ Illinois, Div Endocrinol Diabet & Metab, Chicago, IL 60612 USA. (author)
  • Starling, AnneUniv Louisville, Div Gastroenterol Hepatol & Nutr, Louisville, KY 40402 USA.;Univ Cote Azur, Obstet & Gynecol, Cote Azur, France.;Univ North Carolina Chapel Hill, Dept Epidemiol, Chapel Hill, NC 27599 USA. (author)
  • Tomlinson, Craig R.Univ Louisville, Div Gastroenterol Hepatol & Nutr, Louisville, KY 40402 USA.;Univ Cote Azur, Obstet & Gynecol, Cote Azur, France.;Norris Cotton Canc Ctr, Geisel Sch Med Dartmouth, Dept Mol & Syst Biol, Lebanon, NH 03756 USA. (author)
  • Touma, CharbelUniv Louisville, Div Gastroenterol Hepatol & Nutr, Louisville, KY 40402 USA.;Univ Cote Azur, Obstet & Gynecol, Cote Azur, France. (author)
  • Vondracek, JanUniv Paris, Dept Syst Biol & Bioinformat, INSERM, T3S, Paris, France.;Univ Louisville, Div Gastroenterol Hepatol & Nutr, Louisville, KY 40402 USA.;Univ Cote Azur, Obstet & Gynecol, Cote Azur, France.;Inst Biophys Czech Acad Sci, Dept Cytokinet, Brno, Czech Republic. (author)
  • Saal, Frederick vomUniv Bordeaux, Dept Life & Hlth Sci, INSERM, Pessac, France.;Univ Cote Azur, Obstet & Gynecol, Cote Azur, France.;Univ Missouri, Div Biol Sci, Columbia, MO 65211 USA. (author)
  • Blumberg, BruceUniv Louisville, Div Gastroenterol Hepatol & Nutr, Louisville, KY 40402 USA.;Univ Cote Azur, Obstet & Gynecol, Cote Azur, France. (author)
  • Hlth Environm & Endocrine Disruptor Strategies, Commonweal, Bolinas, CA 92924 USA.Univ Paris, Dept Syst Biol & Bioinformat, INSERM, T3S, Paris, France. (creator_code:org_t)

Related titles

  • In:Biochemical Pharmacology: Elsevier1990006-29521356-18391873-2968

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