id:"swepub:oai:DiVA.org:uu-479892"
Search: id:"swepub:oai:DiVA.org:uu-479892" > Bacterial type I si...
- 1 of 1
- Previous record
- Next record
- To hitlist
- Szalaj, NataliaJagiellonian Univ Med Coll, Fac Pharm, 9 Med St, PL-30688 Krakow, Poland. (author)
Bacterial type I signal peptidase inhibitors-Optimized hits from nature
- Article/chapterEnglish2022
Publisher, publication year, extent ...
- Elsevier,2022
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:uu-479892
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-479892URI
- https://doi.org/10.1016/j.ejmech.2022.114490DOI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- The ever-increasing number of bacteria resistant to the currently available antibacterial agents is a great medical problem today, and new antibiotics with novel mechanisms of action are urgently needed. Among the validated antibacterial drug targets against which new classes of antibiotics might be directed is bacterial type I signal peptidase (SPase I), an essential part of the Tat and Sec secretory systems. SPase I is responsible for the hydrolysis of the N-terminal signal peptides from proteins secreted across the cytoplasmic membrane and plays a key role in bacterial viability and virulence. This review focuses on the antibacterial activity of natural and synthetic SPase I inhibitors reported to date, namely beta-lactams, lipopeptides, and arylomycins, but also an example of SPase I activator was presented.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Läkemedelskemi hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Medicinal Chemistry hsv//eng
- Antibiotics
- Bacterial resistance
- Lipopeptides
- Arylomycin
- ?-lactam
- Bacterial type I signal Peptidase
- SPase I
Added entries (persons, corporate bodies, meetings, titles ...)
- Benediktsdottir, AndreaUppsala universitet,Läkemedelsdesign och läkemedelsutveckling(Swepub:uu)andbe724 (author)
- Rusin, DominikaJagiellonian Univ Med Coll, Fac Pharm, 9 Med St, PL-30688 Krakow, Poland. (author)
- Karlén, AndersUppsala universitet,Institutionen för läkemedelskemi(Swepub:uu)anderskl (author)
- Mowbray, Sherry L,1954-Uppsala universitet,Institutionen för cell- och molekylärbiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)shmow020 (author)
- Wieckowska, AnnaJagiellonian Univ Med Coll, Fac Pharm, 9 Med St, PL-30688 Krakow, Poland. (author)
- Jagiellonian Univ Med Coll, Fac Pharm, 9 Med St, PL-30688 Krakow, Poland.Läkemedelsdesign och läkemedelsutveckling (creator_code:org_t)
Related titles
- In:European Journal of Medicinal Chemistry: Elsevier2380223-52341768-3254
Internet link
Find in a library
- European Journal of Medicinal Chemistry (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Szalaj, Natalia
- Benediktsdottir, ...
- Rusin, Dominika
- Karlén, Anders
- Mowbray, Sherry ...
- Wieckowska, Anna
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Medicinal Chemis ...
- Articles in the publication
- European Journal ...
- By the university
- Uppsala University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
