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Identification, dis...
Identification, discrimination and heterogeneity of fibroblasts
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- Lendahl, Urban (författare)
- Karolinska Inst, Dept Cell & Mol Biol, SE-17177 Stockholm, Sweden.;Karolinska Inst, Dept Neurobiol Care Sci & Soc, SE-14183 Huddinge, Sweden.
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- Muhl, Lars (författare)
- Karolinska Institutet,Karolinska Inst, Dept Med, Blickagangen 16, SE-14157 Huddinge, Sweden.
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- Betsholtz, Christer (författare)
- Uppsala universitet,Vaskulärbiologi,Science for Life Laboratory, SciLifeLab,Karolinska Inst, Dept Med, Blickagangen 16, SE-14157 Huddinge, Sweden.
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Karolinska Institutet Karolinska Inst, Dept Cell & Mol Biol, SE-17177 Stockholm, Sweden;Karolinska Inst, Dept Neurobiol Care Sci & Soc, SE-14183 Huddinge, Sweden. (creator_code:org_t)
- 2022-06-14
- 2022
- Engelska.
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Ingår i: Nature Communications. - : Springer Nature. - 2041-1723. ; 13:1
- Relaterad länk:
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Abstract
Ämnesord
Stäng
- Fibroblasts, the principal cell type of connective tissue, secrete extracellular matrix components during tissue development, homeostasis, repair and disease. Despite this crucial role, the identification and distinction of fibroblasts from other cell types are challenging and laden with caveats. Rapid progress in single-cell transcriptomics now yields detailed molecular portraits of fibroblasts and other cell types in our bodies, which complement and enrich classical histological and immunological descriptions, improve cell class definitions and guide further studies on the functional heterogeneity of cell subtypes and states, origins and fates in physiological and pathological processes. In this review, we summarize and discuss recent advances in the understanding of fibroblast identification and heterogeneity and how they discriminate from other cell types. In this review, the authors look at how recent progress in single-cell transcriptomics complement and enrich the classical, largely morphological, portraits of fibroblasts. The detailed molecular information now available provides new insights into fibroblast identity, heterogeneity and function.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
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