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Sökning: id:"swepub:oai:DiVA.org:uu-480239" > Toxoplasma TgATG9 i...

  • Smith, DavidDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, United States (författare)

Toxoplasma TgATG9 is critical for autophagy and long-term persistence in tissue cysts

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • 2021-04-27
  • eLife Sciences Publications, Ltd,2021
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-480239
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-480239URI
  • https://doi.org/10.7554/elife.59384DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Many of the world’s warm-blooded species are chronically infected with Toxoplasma gondii tissue cysts, including an estimated one-third of the global human population. The cellular processes that permit long-term persistence within the cyst are largely unknown for T. gondii and related coccidian parasites that impact human and animal health. Herein, we show that genetic ablation of TgATG9 substantially reduces canonical autophagy and compromises bradyzoite viability. Transmission electron microscopy revealed numerous structural abnormalities occurring in ∆atg9 bradyzoites. Intriguingly, abnormal mitochondrial networks were observed in TgATG9-deficient bradyzoites, some of which contained numerous different cytoplasmic components and organelles. ∆atg9 bradyzoite fitness was drastically compromised in vitro and in mice, with very few brain cysts identified in mice 5 weeks post-infection. Taken together, our data suggests that TgATG9, and by extension autophagy, is critical for cellular homeostasis in bradyzoites and is necessary for long-term persistence within the cyst of this coccidian parasite.

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Kannan, GeethaDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, United States (författare)
  • Coppens, IsabelleDepartment of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, United States (författare)
  • Wang, FengrongDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, United States (författare)
  • Nguyen, Hoa MaiLaboratory of PathogenHost Interactions, UMR 5235, CNRS, Université de Montpellier, Montpellier, France (författare)
  • Cerutti, AudeLaboratory of PathogenHost Interactions, UMR 5235, CNRS, Université de Montpellier, Montpellier, France (författare)
  • Olafsson, Einar BDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, United States (författare)
  • Rimple, Patrick ADepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, United States (författare)
  • Schultz, Tracey LDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, United States (författare)
  • Mercado Soto, Nayanna MDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, United States (författare)
  • Di Cristina, ManlioDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, United States;Department of Chemistry, Biology and Biotechnology, Università degli Studi di Perugia, Perugia, Italy (författare)
  • Besteiro, SébastienLaboratory of PathogenHost Interactions, UMR 5235, CNRS, Université de Montpellier, Montpellier, France (författare)
  • Carruthers, Vern BDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, United States (författare)
  • Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, United StatesDepartment of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, United States (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:eLIFE: eLife Sciences Publications, Ltd102050-084X

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