Efficacy of Ficus sycomorus (Sycamore Fig) Extract on Intestinal Coccidiosis in Experimentally Infected Rabbits

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Dawod, AhmedUniv Sadat City, Fac Vet Med, Dept Husb & Anim Wealth Dev, Menoufia 32897, Egypt. (author)

Efficacy of Ficus sycomorus (Sycamore Fig) Extract on Intestinal Coccidiosis in Experimentally Infected Rabbits

Article/chapterEnglish2022

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2022-06-18
MDPI,2022
electronicrdacarrier

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LIBRIS-ID:oai:DiVA.org:uu-480374
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-480374URI
https://doi.org/10.3390/life12060917DOI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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This study was conducted to investigate the effect of the Ficus sycomorus extract on Eimeria intestinalis in experimentally infected rabbits. For this purpose, forty male 30-day-old rabbits (Blanc de Bouscat) were divided into four groups (n = 10 in each group). Rabbits kept in the first group served as negative control (non-treated-non-infected). Rabbits kept in the second, third, and fourth groups were challenged at 10 weeks old with 3 x 10(4) E. intestinalis sporulated oocysts. The third and fourth groups were treated orally with diclazuril 10% (0.05 mg/kg body weight) and F. sycomorus (100 mg/Kg) for three consecutive days, respectively. The efficacy was assessed based on the growth performance parameters, clinical symptoms, oocyst shedding, histopathological findings, and hematological parameters for 16 days post challenge. The study revealed that rabbits treated with F. sycomorus methanolic extract and diclazuril showed mild clinical symptoms with a significant decrease in oocyst shedding compared with the positive control. Moreover, the diclazuril-treated group showed the highest leukocytic count and the lowest monocytes percentage compared with other groups. Furthermore, the lowest lymphocytes percentage was recorded in the control positive group. Histopathologically, moderate coccidia infestation in the intestinal mucosa and moderate hydropic degeneration of hepatocytes were observed in the diclazuril treated group compared with the negative control. However, mild coccidia infestation in the intestinal mucosa and slight coagulative necrosis of hepatocytes was found in the F. sycomorus treated group. In conclusion, F. sycomorus methanolic extract had promising effects on the live performance, oocyst count, and blood variables, while it possesses adverse consequences on the hepatic tissues. Further studies are required to optimize the dose and extraction method to mitigate its side effects.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Fysiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Physiology hsv//eng
Eimeria intestinalis
rabbits
Ficus sycomorus
coccidia

Added entries (persons, corporate bodies, meetings, titles ...)

Fathalla, SaidUniv Sadat City, Fac Vet Med, Dept Physiol, Sadat City 32897, Egypt. (author)
El-Seedi, HeshamUppsala universitet,Farmakognosi,Institutionen för farmaceutisk biovetenskap,Jiangsu Univ, Int Res Ctr Food Nutr & Safety, Zhenjiang 212013, Jiangsu, Peoples R China.;Menoufia Univ, Fac Sci, Dept Chem, Shibin Al Kawm 32512, Egypt.(Swepub:uu)heels173 (author)
Hammad, Mohamed A.Univ Sadat City, Fac Pharm, Dept Analyt Chem, Sadat City 32897, Egypt. (author)
Osman, NohaUniv Sadat City, Fac Vet Med, Dept Husb & Anim Wealth Dev, Menoufia 32897, Egypt. (author)
Abosheriba, NagwaUniv Sadat City, Fac Vet Med, Dept Husb & Anim Wealth Dev, Menoufia 32897, Egypt. (author)
Anis, AnisUniv Sadat City, Fac Vet Med, Dept Pathol, Sadat City 32897, Egypt. (author)
Shehata, Awad A.Univ Sadat City, Fac Vet Med, Avian & Rabbit Dis Dept, Sadat City 32897, Egypt.;PerNaturam GmbH, Res & Dev Sect, D-56290 Godenroth, Germany.;Prophy Inst Appl Prophylaxis, D-59159 Bonen, Germany. (author)
Elkhatam, AhmedUniv Sadat City, Fac Vet Med, Dept Parasitol, Sadat City 32897, Egypt. (author)
Univ Sadat City, Fac Vet Med, Dept Husb & Anim Wealth Dev, Menoufia 32897, Egypt.Univ Sadat City, Fac Vet Med, Dept Physiol, Sadat City 32897, Egypt. (creator_code:org_t)

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In:Life: MDPI12:62075-1729

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By the author/editor: Dawod, Ahmed; Fathalla, Said; El-Seedi, Hesham; Hammad, Mohamed ...; Osman, Noha; Abosheriba, Nagw ...; show more...; Anis, Anis; Shehata, Awad A.; Elkhatam, Ahmed; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Physiology

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