Pharmacogenetics and Pain Treatment with a Focus on Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and Antidepressants: A Systematic Review

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Zobdeh, FarzinUppsala Univ, Div Funct Pharmacol & Neurosci, Dept Surg Sci, Biomed Ctr BMC, Husargatan 3 POB 593, S-75124 Uppsala, Sweden. (author)

Pharmacogenetics and Pain Treatment with a Focus on Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and Antidepressants : A Systematic Review

Article/chapterEnglish2022

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2022-06-01
MDPI,2022
electronicrdacarrier

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LIBRIS-ID:oai:DiVA.org:uu-480390
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-480390URI
https://doi.org/10.3390/pharmaceutics14061190DOI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:for swepub-publicationtype

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Background: This systematic review summarizes the impact of pharmacogenetics on the effect and safety of non-steroidal anti-inflammatory drugs (NSAIDs) and antidepressants when used for pain treatment. Methods: A systematic literature search was performed according to the preferred reporting items for systematic reviews and meta-analysis (PRISMA) guidelines regarding the human in vivo efficacy and safety of NSAIDs and antidepressants in pain treatment that take pharmacogenetic parameters into consideration. Studies were collected from PubMed, Scopus, and Web of Science up to the cutoff date 18 October 2021. Results: Twenty-five articles out of the 6547 initially detected publications were identified. Relevant medication-gene interactions were noted for drug safety. Interactions important for pain management were detected for (1) ibuprofen/CYP2C9; (2) celecoxib/CYP2C9; (3) piroxicam/CYP2C8, CYP2C9; (4) diclofenac/CYP2C9, UGT2B7, CYP2C8, ABCC2; (5) meloxicam/CYP2C9; (6) aspirin/CYP2C9, SLCO1B1, and CHST2; (7) amitriptyline/CYP2D6 and CYP2C19; (8) imipramine/CYP2C19; (9) nortriptyline/CYP2C19, CYP2D6, ABCB1; and (10) escitalopram/HTR2C, CYP2C19, and CYP1A2. Conclusions: Overall, a lack of well powered human in vivo studies assessing the pharmacogenetics in pain patients treated with NSAIDs or antidepressants is noted. Studies indicate a higher risk for partly severe side effects for the CYP2C9 poor metabolizers and NSAIDs. Further in vivo studies are needed to consolidate the relevant polymorphisms in NSAID safety as well as in the efficacy of NSAIDs and antidepressants in pain management.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Farmakologi och toxikologi hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Pharmacology and Toxicology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Farmaceutiska vetenskaper hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Pharmaceutical Sciences hsv//eng
pharmacogenetics
pharmacogenomics
pain management
non-steroidal anti-inflammatory drugs
NSAID
antidepressants
safety
efficacy
genetic polymorphisms

Added entries (persons, corporate bodies, meetings, titles ...)

Eremenko, Ivan I.Uppsala Univ, Div Funct Pharmacol & Neurosci, Dept Surg Sci, Biomed Ctr BMC, Husargatan 3 POB 593, S-75124 Uppsala, Sweden.;Ltd Liable Co LLC, Adv Mol Technol, Moscow 354340, Russia. (author)
Akan, Mikail A.Uppsala Univ, Div Funct Pharmacol & Neurosci, Dept Surg Sci, Biomed Ctr BMC, Husargatan 3 POB 593, S-75124 Uppsala, Sweden.;Ltd Liable Co LLC, Adv Mol Technol, Moscow 354340, Russia. (author)
Tarasov, Vadim V.Ltd Liable Co LLC, Adv Mol Technol, Moscow 354340, Russia. (author)
Chubarev, Vladimir N.Ltd Liable Co LLC, Adv Mol Technol, Moscow 354340, Russia. (author)
Schiöth, Helgi B.Uppsala universitet,Funktionell farmakologi och neurovetenskap,Uppsala Univ, Div Funct Pharmacol & Neurosci, Dept Surg Sci, Biomed Ctr BMC, Husargatan 3 POB 593, S-75124 Uppsala, Sweden.(Swepub:uu)helgschi (author)
Mwinyi, JessicaUppsala universitet,WoMHeR (Centre for Women’s Mental Health during the Reproductive Lifespan)(Swepub:uu)jesmw847 (author)
Uppsala Univ, Div Funct Pharmacol & Neurosci, Dept Surg Sci, Biomed Ctr BMC, Husargatan 3 POB 593, S-75124 Uppsala, Sweden.Uppsala Univ, Div Funct Pharmacol & Neurosci, Dept Surg Sci, Biomed Ctr BMC, Husargatan 3 POB 593, S-75124 Uppsala, Sweden.;Ltd Liable Co LLC, Adv Mol Technol, Moscow 354340, Russia. (creator_code:org_t)

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In:Pharmaceutics: MDPI14:61999-4923

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Pharmacology and ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Pharmaceutical S ...

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