Search: WFRF:(Wibroe Morten) >
Left-handedness sho...
Left-handedness should not be overrated as a risk factor for postoperative speech impairment in children after posterior fossa tumour surgery : a prospective European multicentre study
-
- Gronbaek, Jonathan Kjaer (author)
- Copenhagen Univ Hosp, Dept Neurosurg, Rigshosp, Blegdamsvej 9, DK-2100 Copenhagen E, Denmark.;Copenhagen Univ Hosp, Dept Paediat & Adolescent Med, Rigshosp, Blegdamsvej 9, DK-2100 Copenhagen E, Denmark.
-
- Laustsen, Aske Foldbjerg (author)
- Copenhagen Univ Hosp, Dept Neurosurg, Rigshosp, Blegdamsvej 9, DK-2100 Copenhagen E, Denmark.;Copenhagen Univ Hosp, Dept Paediat & Adolescent Med, Rigshosp, Blegdamsvej 9, DK-2100 Copenhagen E, Denmark.
-
- Toescu, Sebastian (author)
- Great Ormond St Hosp Sick Children, Dept Neurosurg, Great Ormond St, London WC1N 3JH, England.;UCL, Dev Imaging & Biophys Sect, Great Ormond St Inst Child Hlth, 30 Guilford St, London WC1N 1EH, England.
-
show more...
-
- Pizer, Barry (author)
- Univ Liverpool, Liverpool L69 3BX, Merseyside, England.
-
- Mallucci, Conor (author)
- Alder Hey Childrens NHS Fdn Trust, Dept Paediat Neurosurg, E Prescot Rd, Liverpool L14 5AB, Merseyside, England.
-
- Aquilina, Kristian (author)
- Great Ormond St Hosp Sick Children, Dept Neurosurg, Great Ormond St, London WC1N 3JH, England.
-
- Molinari, Emanuela (author)
- Univ Glasgow, Queen Elizabeth Univ Hosp, Dept Neurol, Univ Ave, Glasgow G12 8QQ, Lanark, Scotland.
-
- Hjort, Magnus Aasved (author)
- St Olavs Hosp, Dept Pediat Hematol & Oncol, N-7006 Trondheim, Norway.
-
- Gumbeleviciene, Lingvita (author)
- Hosp Lithuanian Univ Hlth Sci Kauno Klin, Dept Neurol, Eiveniu 2, LT-50161 Kaunas, Lithuania.
-
- Hauser, Peter (author)
- Semmelweis Univ, Dept Pediat 2, Tuzolto U 7-9, H-1094 Budapest, Hungary.;BAZ Cty Cent Hosp, Velkey Laszlo Childs Hlth Ctr, Szentpeteri Kapu 72-76, H-3526 Miskolc, Hungary.;Univ Teaching Hosp, Szentpeteri Kapu 72-76, H-3526 Miskolc, Hungary.
-
- Palmafy, Beatrix (author)
- Natl Inst Neurosci, Amerikai Ut 57, H-1145 Budapest, Hungary.
-
- van Baarsen, Kirsten (author)
- Princess Maxima Ctr Pediat Oncol, Heidelberglaan 25, NL-3584 CS Utrecht, Netherlands.
-
- Hoving, Eelco (author)
- Princess Maxima Ctr Pediat Oncol, Heidelberglaan 25, NL-3584 CS Utrecht, Netherlands.
-
- Zipfel, Julian (author)
- Univ Hosp Tuebingen, Dept Neurosurg, Pediat Neurosurg, Hoppe Seyler Str 3, D-72076 Tubingen, Germany.
-
- Ehrstedt, Christoffer (author)
- Uppsala universitet,Barnonkologisk och neurologisk forskning
-
- Grillner, Pernilla (author)
- Karolinska Institutet
-
- Callesen, Michael Thude (author)
- HC Andersen Childrens Hosp, Dept Pediat Oncol & Haematol, Klovervaenget 23C, DK-5000 Odense, Denmark.
-
- Fric, Radek (author)
- Oslo Univ Hosp, Dept Neurosurg, Postboks 4950 Nydalen, N-0424 Oslo, Norway.
-
- Wibroe, Morten (author)
- Copenhagen Univ Hosp, Dept Paediat & Adolescent Med, Rigshosp, Blegdamsvej 9, DK-2100 Copenhagen E, Denmark.
-
- Nysom, Karsten (author)
- Copenhagen Univ Hosp, Dept Paediat & Adolescent Med, Rigshosp, Blegdamsvej 9, DK-2100 Copenhagen E, Denmark.
-
- Schmiegelow, Kjeld (author)
- Copenhagen Univ Hosp, Dept Paediat & Adolescent Med, Rigshosp, Blegdamsvej 9, DK-2100 Copenhagen E, Denmark.;Univ Copenhagen, Fac Med, Inst Clin Med, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.
-
- Sehested, Astrid (author)
- Copenhagen Univ Hosp, Dept Paediat & Adolescent Med, Rigshosp, Blegdamsvej 9, DK-2100 Copenhagen E, Denmark.
-
- Mathiasen, Rene (author)
- Copenhagen Univ Hosp, Dept Paediat & Adolescent Med, Rigshosp, Blegdamsvej 9, DK-2100 Copenhagen E, Denmark.
-
- Juhler, Marianne (author)
- Copenhagen Univ Hosp, Dept Neurosurg, Rigshosp, Blegdamsvej 9, DK-2100 Copenhagen E, Denmark.;Univ Copenhagen, Fac Med, Inst Clin Med, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.;Aarhus Univ Hosp, Dept Neurosurg, Blvd 99, DK-8200 Aarhus, Denmark.
-
show less...
-
Copenhagen Univ Hosp, Dept Neurosurg, Rigshosp, Blegdamsvej 9, DK-2100 Copenhagen E, Denmark;Copenhagen Univ Hosp, Dept Paediat & Adolescent Med, Rigshosp, Blegdamsvej 9, DK-2100 Copenhagen E, Denmark. Great Ormond St Hosp Sick Children, Dept Neurosurg, Great Ormond St, London WC1N 3JH, England.;UCL, Dev Imaging & Biophys Sect, Great Ormond St Inst Child Hlth, 30 Guilford St, London WC1N 1EH, England. (creator_code:org_t)
- 2022-06-27
- 2022
- English.
-
In: Child's Nervous System. - : Springer Nature. - 0256-7040 .- 1433-0350. ; 38:8, s. 1479-1485
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- Purpose Cerebellar mutism syndrome (CMS) is a severe neurological complication of posterior fossa tumour surgery in children, and postoperative speech impairment (POSI) is the main component. Left-handedness was previously suggested as a strong risk factor for POSI. The aim of this study was to investigate the relationship between handedness and the risk of POSI. Methods We prospectively included children (aged < 18 years) undergoing surgery for posterior fossa tumours in 26 European centres. Handedness was assessed pre-operatively and postoperative speech status was categorised as either POSI (mutism or reduced speech) or habitual speech, based on the postoperative clinical assessment. Logistic regression was used in the risk factor analysis of POSI as a dichotomous outcome. Results Of the 500 children included, 37 (7%) were excluded from the present analysis due to enrolment at a reoperation; another 213 (43%) due to missing data about surgery (n = 37) and/or handedness (n = 146) and/or postoperative speech status (n = 53). Out of the remaining 250 (50%) patients, 20 (8%) were left-handed and 230 (92%) were right-handed. POSI was observed equally frequently regardless of handedness (5/20 [25%] in left-handed, 61/230 [27%] in right-handed, OR: 1.08 [95% CI: 0.40-3.44], p = 0.882), also when adjusted for tumour histology, location and age. Conclusion We found no difference in the risk of POSI associated with handedness. Our data do not support the hypothesis that handedness should be of clinical relevance in the risk assessment of CMS.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Cerebellar mutism syndrome
- Posterior fossa syndrome
- Handedness
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Gronbaek, Jonath ...
-
Laustsen, Aske F ...
-
Toescu, Sebastia ...
-
Pizer, Barry
-
Mallucci, Conor
-
Aquilina, Kristi ...
-
show more...
-
Molinari, Emanue ...
-
Hjort, Magnus Aa ...
-
Gumbeleviciene, ...
-
Hauser, Peter
-
Palmafy, Beatrix
-
van Baarsen, Kir ...
-
Hoving, Eelco
-
Zipfel, Julian
-
Ehrstedt, Christ ...
-
Grillner, Pernil ...
-
Callesen, Michae ...
-
Fric, Radek
-
Wibroe, Morten
-
Nysom, Karsten
-
Schmiegelow, Kje ...
-
Sehested, Astrid
-
Mathiasen, Rene
-
Juhler, Marianne
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Neurology
- Articles in the publication
-
Child's Nervous ...
- By the university
-
Uppsala University
-
Karolinska Institutet