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Comparative LC-LTQ-...
Comparative LC-LTQ-MS-MS Analysis of the Leaf Extracts of Lantana camara and Lantana montevidensis Growing in Egypt with Insights into Their Antioxidant, Anti-Inflammatory, and Cytotoxic Activities
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- El-Din, Mariam I. Gamal (författare)
- Ain Shams Univ, Fac Pharm, Dept Pharmacognosy, Cairo 11566, Egypt.
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- Fahmy, Nouran M. (författare)
- Ain Shams Univ, Fac Pharm, Dept Pharmacognosy, Cairo 11566, Egypt.
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- Wu, Fulin (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Jilin Univ, Sch Pharmaceut Sci, Changchun 130021, Peoples R China.
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- Salem, Maha M. (författare)
- Tanta Univ, Fac Sci, Chem Dept, Biochem Div, Tanta 31527, Egypt.
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- Khattab, Omar M. (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Menoufia Univ, Fac Sci, Dept Chem, Shibin Al Kawm 32512, Egypt.
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- El-Seedi, Hesham (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Menoufia Univ, Fac Sci, Dept Chem, Shibin Al Kawm 32512, Egypt.;Jiangsu Univ, Int Res Ctr Food Nutr & Safety, Zhenjiang 212013, Jiangsu, Peoples R China.;Jiangsu Univ, Jiangsu Educ Dept, Int Joint Res Lab Intelligent Agr & Agriprod Proc, Zhenjiang 212013, Jiangsu, Peoples R China.
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- Korinek, Michal (författare)
- Kaohsiung Med Univ, Coll Pharm, Grad Inst Nat Prod, Kaohsiung 80708, Taiwan.;Chang Gung Univ, Coll Med, Grad Inst Nat Prod, Taoyuan 33302, Taiwan.
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- Hwang, Tsong-Long (författare)
- Chang Gung Univ, Coll Med, Grad Inst Nat Prod, Taoyuan 33302, Taiwan.;Chang Gung Univ Sci & Technol, Coll Human Ecol, Grad Inst Hlth Ind Technol, Res Ctr Chinese Herbal Med, Taoyuan 33302, Taiwan.;Chang Gung Mem Hosp, Dept Anesthesiol, Taoyuan 33305, Taiwan.;Ming Chi Univ Technol, Dept Chem Engn, New Taipei 243303, Taiwan.
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- Osman, Ahmed K. (författare)
- South Valley Univ, Fac Sci, Dept Bot & Microbiol, Qena 83523, Egypt.
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- El-Shazly, Mohamed (författare)
- Ain Shams Univ, Fac Pharm, Dept Pharmacognosy, Cairo 11566, Egypt.;German Univ Cairo, Fac Pharm & Biotechnol, Dept Pharmaceut Biol, Cairo 11835, Egypt.
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- Fayez, Shaimaa (författare)
- Ain Shams Univ, Fac Pharm, Dept Pharmacognosy, Cairo 11566, Egypt.
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Ain Shams Univ, Fac Pharm, Dept Pharmacognosy, Cairo 11566, Egypt Institutionen för farmaceutisk biovetenskap (creator_code:org_t)
- 2022-06-27
- 2022
- Engelska.
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Ingår i: PLANTS. - : MDPI. - 2223-7747. ; 11:13
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Lantana camara L. and Lantana montevidensis Briq. (F. Verbenaceae) are invasive ornamental weeds native to the tropical regions of Africa and America. The leaves of both species have been traditionally used as infusions for treating fever, rheumatism, and cancer. LC-MS-MS-guided profiling of the methanolic extracts of the leaves of L. camara and L. montevidensis growing in Egypt led to the putative identification of 59 compounds belonging to terpenoids, flavonoids, iridoid glycosides, phenolic acids, and their derivatives. The in vitro antioxidants and anti-inflammatory and anticancer activities of the two extracts were investigated. L. camara and L. montevidensis inhibited DPPH center dot (IC50 = 34.01 +/- 1.32 and 47.43 +/- 1.74 mu g/ mL), ABTS (IC50 = 30.73 +/- 1.42 and 40.37 +/- 1.51 mu g/mL), and superoxide anion (IC50 = 1.57 +/- 0.19 and 1.31 +/- 0.14 mu g/mL) free radicals. A potent antiinflammatory effect was observed for both species through the inhibition of elastase release in fMLF/CB-induced human neutrophils (IC50 = 2.40 +/- 0.16 and 1.90 +/- 0.07 mu g/mL). The extracts showed significant cytotoxic activity against a panel of cancer cell lines with the most potent activity against Caco cells (IC50 = 45.65 +/- 1.64 and 40.67 +/- 1.52 mu g /mL for L. camara and L. montevidensis, respectively). Western blotting supported by FACS analysis revealed that the extracts inhibited cancer cell proliferation, reduced metastasis, and induced apoptosis resulting in cell cycle arrest. This was achieved via increasing mRNA and protein expressions of p53 and GSK-313 as well as decreasing the expression of PI3K, Akt, and cyclin D1.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Nyckelord
- Lantana camara
- Lantana montevidensis
- antioxidant
- anti-inflammatory
- cytotoxicity
- LC-MS-MS
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El-Din, Mariam I ...
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Fahmy, Nouran M.
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Wu, Fulin
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Salem, Maha M.
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Khattab, Omar M.
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El-Seedi, Hesham
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Korinek, Michal
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Hwang, Tsong-Lon ...
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Osman, Ahmed K.
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El-Shazly, Moham ...
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Fayez, Shaimaa
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