Sökning: WFRF:(Kour Anupreet) >
Hematopoietic loss ...
-
Sano, SoichiHematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.;Department of Cardiovascular Medicine, Osaka Metropolitan University Graduate School of Medicine, Osaka 545-8585, Japan.
(författare)
Hematopoietic loss of Y chromosome leads to cardiac fibrosis and heart failure mortality
- Artikel/kapitelEngelska2022
Förlag, utgivningsår, omfång ...
-
American Association for the Advancement of Science (AAAS),2022
-
printrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:uu-481413
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-481413URI
-
https://doi.org/10.1126/science.abn3100DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
Hematopoietic mosaic loss of Y chromosome (mLOY) is associated with increased risk of mortality and age-related diseases in men, but the causal and mechanistic relationships have yet to be established. Here, we show that male mice reconstituted with bone marrow cells lacking the Y chromosome display increased mortality and age-related profibrotic pathologies including reduced cardiac function. Cardiac macrophages lacking the Y chromosome exhibited polarization toward a more fibrotic phenotype, and treatment with a transforming growth factor β1–neutralizing antibody ameliorated cardiac dysfunction in mLOY mice. A prospective study revealed that mLOY in blood is associated with an increased risk for cardiovascular disease and heart failure–associated mortality. Together, these results indicate that hematopoietic mLOY causally contributes to fibrosis, cardiac dysfunction, and mortality in men.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Horitani, KeitaHematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
(författare)
-
Ogawa, HayatoHematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
(författare)
-
Halvardson, Jonatan,1982-Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik,Lars Forsberg(Swepub:uu)jonha894
(författare)
-
Chavkin, Nicholas W.Hematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.;Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
(författare)
-
Wang, YingHematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
(författare)
-
Sano, MihoHematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
(författare)
-
Mattisson, JonasUppsala universitet,Medicinsk genetik och genomik,Science for Life Laboratory, SciLifeLab,Lars Forsberg(Swepub:uu)jonma819
(författare)
-
Hata, AtsushiChiba University Graduate School of Medicine, Department of General Thoracic Surgery, Chiba 260-8670, Japan.
(författare)
-
Danielsson, MarcusUppsala universitet,Medicinsk genetik och genomik,Science for Life Laboratory, SciLifeLab,Lars Forsberg(Swepub:uu)marda231
(författare)
-
Miura-Yura, EmiriHematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
(författare)
-
Zaghlool, Ammar,1980-Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik,Lars Forsberg(Swepub:uu)ammza789
(författare)
-
Evans, Megan A.Hematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
(författare)
-
Fall, Tove,1979-Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi(Swepub:uu)tovfa878
(författare)
-
De Hoyos, Henry N.Hematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
(författare)
-
Sundström, Johan,Professor,1971-Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Klinisk epidemiologi(Swepub:uu)johasund
(författare)
-
Yura, YoshimitsuHematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
(författare)
-
Kour, AnupreetHematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
(författare)
-
Arai, YoheiHematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
(författare)
-
Thel, Mark C.Hematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
(författare)
-
Arai, YukaHematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
(författare)
-
Mychaleckyj, Josyf C.Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA.
(författare)
-
Hirschi, Karen K.Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
(författare)
-
Forsberg, Lars A.,1974-Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik,The Beijer Laboratory, Uppsala University, 75185 Uppsala, Sweden.,Lars Forsberg(Swepub:uu)larfo354
(författare)
-
Walsh, KennethHematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
(författare)
-
Hematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.;Department of Cardiovascular Medicine, Osaka Metropolitan University Graduate School of Medicine, Osaka 545-8585, Japan.Hematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Science: American Association for the Advancement of Science (AAAS)377:6603, s. 292-2970036-80751095-9203
Internetlänk
Hitta via bibliotek
-
Science
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- Av författaren/redakt...
-
Sano, Soichi
-
Horitani, Keita
-
Ogawa, Hayato
-
Halvardson, Jona ...
-
Chavkin, Nichola ...
-
Wang, Ying
-
visa fler...
-
Sano, Miho
-
Mattisson, Jonas
-
Hata, Atsushi
-
Danielsson, Marc ...
-
Miura-Yura, Emir ...
-
Zaghlool, Ammar, ...
-
Evans, Megan A.
-
Fall, Tove, 1979 ...
-
De Hoyos, Henry ...
-
Sundström, Johan ...
-
Yura, Yoshimitsu
-
Kour, Anupreet
-
Arai, Yohei
-
Thel, Mark C.
-
Arai, Yuka
-
Mychaleckyj, Jos ...
-
Hirschi, Karen K ...
-
Forsberg, Lars A ...
-
Walsh, Kenneth
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinska och f ...
-
och Medicinsk geneti ...
- Artiklar i publikationen
-
Science
- Av lärosätet
-
Uppsala universitet