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Biomarkers and hear...
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Aulin, JuliaUppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi
(author)
Biomarkers and heart failure events in patients with atrial fibrillation in the ARISTOTLE trial evaluated by a multi-state model
- Article/chapterEnglish2022
Publisher, publication year, extent ...
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Elsevier,2022
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electronicrdacarrier
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LIBRIS-ID:oai:DiVA.org:uu-481424
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-481424URI
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https://doi.org/10.1016/j.ahj.2022.03.009DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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BackgroundAtrial fibrillation (AF) and heart failure (HF) often coexist. We investigated the prognostic impact of biomarkers on the development of HF and death in patients with AF and different left ventricular systolic function considering the influence of competing events.MethodsThe study included 11,818 patients with AF from the ARISTOTLE trial who at entry had information on history of HF, an estimate of left ventricular function and plasma samples for determination of biomarkers representing cardiorenal dysfunction (NT-proBNP, troponin T, cystatin C) and inflammation (GDF-15, IL-6, CRP). Patients were categorized into: (I) HF with reduced ejection fraction (HFrEF, n = 2,048), (II) HF with preserved ejection fraction (HFpEF, n = 2,520), and (III) No HF (n = 7,250). Biomarker associations with HF hospitalization and death were analyzed using a multi-state model accounting also for repeated events.ResultsBaseline levels of NT-proBNP, troponin T, cystatin C, GDF-15, IL-6, and CRP were highest in HFrEF and lowest in No HF. During median 1.9 years follow-up, 546 patients were hospitalized at least once for HF and 819 died. Higher levels of all investigated biomarkers were associated with both outcomes (all P < .0001), with highest event rates in HFrEF and lowest in No HF. The associations remained after adjustments and were more pronounced for first than for recurrent events.ConclusionsIn anticoagulated patients with AF, biomarkers indicating cardiorenal dysfunction and inflammation improve the identification of patients at risk of developing HF or worsening of already existing HF. These biomarkers might be useful for targeting novel HF therapies in patients with AF.
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Hijazi, ZiadUppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi(Swepub:uu)ziahi940
(author)
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Lindbäck, JohanUppsala universitet,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)jolin255
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Alexander, John H.Duke Clin Res Inst, Duke Hlth, Durham, NC USA.
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Gersh, Bernard J.Mayo Clin, Coll Med & Sci, Rochester, MN USA.
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Granger, Christopher B.Duke Clin Res Inst, Duke Hlth, Durham, NC USA.
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Hanna, MichaelBristol Myers Squibb, Princeton, NJ USA.
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Horowitz, JohnUniv Adelaide, Basil Hetzel Inst, Adelaide, SA, Australia.
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Lopes, Renato D.Duke Clin Res Inst, Duke Hlth, Durham, NC USA.
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McMurray, John J. V.Univ Glasgow, BHF Cardiovasc Res Ctr, Glasgow, Scotland.
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Oldgren, Jonas,1964-Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)jonaoldg
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Siegbahn, Agneta,1947-Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Klinisk kemi(Swepub:uu)agsie424
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Wallentin, Lars,1943-Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)larswall
(author)
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Uppsala universitetUppsala kliniska forskningscentrum (UCR)
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In:American Heart Journal: Elsevier251, s. 13-240002-87031097-6744
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Aulin, Julia
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Hijazi, Ziad
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Hanna, Michael
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- MEDICAL AND HEALTH SCIENCES
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