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  • Saleh, MunaLinköpings universitet,Linköping University,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland (author)

Variation of Complement Protein Levels in Maternal Plasma and Umbilical Cord Blood during Normal Pregnancy : An Observational Study

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2022-06-22
  • MDPI AG,2022
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-481808
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-481808URI
  • https://doi.org/10.3390/jcm11133611DOI
  • https://lup.lub.lu.se/record/07458001-d258-4f23-9e94-3f8ad8b1735dURI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-187481URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|Region Ostergotland (ALF Grants) [RO-932055]; Swedish Rheumatism Association [R-939149]; Ulla and Roland Gustafsson Foundation; King Gustaf Vs 80-year Anniversary foundation [FAI-2020-0663]; King Gustaf V and Queen Victorias Freemasons foundation
  • The complement system constitutes a crucial part of the innate immunity, mediating opsonization, lysis, inflammation, and elimination of potential pathogens. In general, there is an increased activity of the complement system during pregnancy, which is essential for maintaining the host's defense and fetal survival. Unbalanced or excessive activation of the complement system in the placenta is associated with pregnancy complications, such as miscarriage, preeclampsia, and premature birth. Nonetheless, the actual clinical value of monitoring the activation of the complement system during pregnancy remains to be investigated. Unfortunately, normal reference values specifically for pregnant women are missing, and for umbilical cord blood (UCB), data on complement protein levels are scarce. Herein, complement protein analyses (C1q, C3, C4, C3d levels, and C3d/C3 ratio) were performed in plasma samples from 100 healthy, non-medicated and non-smoking pregnant women, collected during different trimesters and at the time of delivery. In addition, UCB was collected at all deliveries. Maternal plasma C1q and C3d/C3 ratio showed the highest mean values during the first trimester, whereas C3, C4, and C3d had rising values until delivery. We observed low levels of C1q and C4 as well as increased C3d and C3d/C3 ratio, particularly during the first trimester, as a sign of complement activation in some women. However, the reference limits of complement analyses applied for the general population appeared appropriate for the majority of the samples. As expected, the mean complement concentrations in UCB were much lower than in maternal plasma, due to the immature complement system in neonates.

Subject headings and genre

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  • Compagno, MicheleLund University,Lunds universitet,Reumatologi,Forskargrupper vid Lunds universitet,Rheumatology,Lund University Research Groups,Lund Univ, Sweden(Swepub:lu)reum-mco (author)
  • Pihl, SofiaLinköpings universitet,Linköping University,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Region Östergötland, Kvinnokliniken US(Swepub:liu)sofkl98 (author)
  • Strevens, HelenaLund University,Lunds universitet,Obstetrik och gynekologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Obstetrics and Gynaecology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Sweden(Swepub:lu)gyn-hst (author)
  • Persson, BarbroUppsala University,Uppsala universitet,Klinisk immunologi,Uppsala Univ, Sweden(Swepub:uu)barpe890 (author)
  • Wetterö, JonasLinköpings universitet,Linköping University,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland(Swepub:liu)jonwe26 (author)
  • Nilsson, BoUppsala University,Uppsala universitet,Institutionen för immunologi, genetik och patologi,Uppsala Univ, Sweden(Swepub:uu)bonils (author)
  • Sjöwall, ChristopherLinköpings universitet,Linköping University,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland(Swepub:liu)chrsj93 (author)
  • Linköping UniversityAvdelningen för inflammation och infektion (creator_code:org_t)

Related titles

  • In:Journal of Clinical Medicine: MDPI AG11:132077-0383

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