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  • Holliday, Katelyn M.Duke Univ, Sch Med, Dept Family Med & Community Hlth, Durham, NC USA.;Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27515 USA. (författare)

Gaseous air pollutants and DNA methylation in a methylome-wide association study of an ethnically and environmentally diverse population of US adults

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • Elsevier,2022
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-482090
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-482090URI
  • https://doi.org/10.1016/j.envres.2022.113360DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Epigenetic mechanisms may underlie air pollution-health outcome associations. We estimated gaseous air pollutant-DNA methylation (DNAm) associations using twelve subpopulations within Women's Health Initiative (WHI) and Atherosclerosis Risk in Communities (ARIC) cohorts (n = 8397; mean age 61.3 years; 83% female; 46% African-American, 46% European-American, 8% Hispanic/Latino). We used geocoded participant address-specific mean ambient carbon monoxide (CO), nitrogen oxides (NO2; NOx), ozone (O-3), and sulfur dioxide (SO2) concentrations estimated over the 2-, 7-, 28-, and 365-day periods before collection of blood samples used to generate Illumina 450 k array leukocyte DNAm measurements. We estimated methylome-wide, subpopulation-and race/ethnicity-stratified pollutant-DNAm associations in multi-level, linear mixed-effects models adjusted for sociodemographic, behavioral, meteorological, and technical covariates. We combined stratum-specific estimates in inverse variance-weighted meta-analyses and characterized significant associations (false discovery rate; FDR<0.05) at Cytosine-phosphate-Guanine (CpG) sites without among-strata heterogeneity (P-Cochran's Q > 0.05). We attempted replication in the Cooperative Health Research in Region of Augsburg (KORA) study and Normative Aging Study (NAS). We observed a -0.3 (95% CI: -0.4, -0.2) unit decrease in percent DNAm per interquartile range (IQR, 7.3 ppb) increase in 28-day mean NO2 concentration at cg01885635 (chromosome 3; regulatory region 290 bp upstream from ZNF621; FDR = 0.03). At intragenic sites cg21849932 (chromosome 20; LIME1; intron 3) and cg05353869 (chromosome 11; KLHL35; exon 2), we observed a -0.3 (95% CI: -0.4, -0.2) unit decrease (FDR = 0.04) and a 1.2 (95% CI: 0.7, 1.7) unit increase (FDR = 0.04), respectively, in percent DNAm per IQR (17.6 ppb) increase in 7-day mean ozone concentration. Results were not fully replicated in KORA and NAS. We identified three CpG sites potentially susceptible to gaseous air pollution-induced DNAm changes near genes relevant for cardiovascular and lung disease. Further harmonized investigations with a range of gaseous pollutants and averaging durations are needed to determine the effect of gaseous air pollutants on DNA methylation and ultimately gene expression.

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Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Gondalia, RahulUniv N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27515 USA. (författare)
  • Baldassari, AntoineUniv N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27515 USA. (författare)
  • Justice, Anne E.Geisinger Hlth Syst, Danville, PA USA. (författare)
  • Stewart, James D.Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27515 USA. (författare)
  • Liao, DuanpingPenn State Univ, Dept Publ Hlth Sci, Coll Med, Div Epidemiol, Hershey, PA USA. (författare)
  • Yanosky, Jeff D.Penn State Univ, Dept Publ Hlth Sci, Coll Med, Div Epidemiol, Hershey, PA USA. (författare)
  • Jordahl, Kristina M.Univ Washington, Dept Epidemiol, Sch Publ Hlth, Seattle, WA 98195 USA. (författare)
  • Bhatti, ParveenBC Canc, Canc Control Res, Vancouver, BC, Canada. (författare)
  • Assimes, Themistocles L.Stanford Univ, Dept Med, Sch Med, Stanford, CA 94305 USA. (författare)
  • Pankow, James S.Univ Minnesota, Div Epidemiol & Community Hlth, Minneapolis, MN USA. (författare)
  • Guan, WeihuaUniv Minnesota, Div Biostat, Minneapolis, MN USA. (författare)
  • Fornage, MyriamUniv Texas Hlth Sci Ctr Houston, Brown Fdn, Inst Mol Med, McGovern Med Sch, Houston, TX 77030 USA.;Univ Texas Hlth Sci Ctr Houston, Human Genet Ctr, Sch Publ Hlth, Houston, TX 77030 USA. (författare)
  • Bressler, JanUniv Texas Hlth Sci Ctr Houston, Human Genet Ctr, Sch Publ Hlth, Houston, TX 77030 USA. (författare)
  • North, Kari E.Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27515 USA. (författare)
  • Conneely, Karen N.Emory Univ, Sch Med, Dept Human Genet, Atlanta, GA USA. (författare)
  • Li, YunUniv N Carolina, Dept Genet, Chapel Hill, NC 27515 USA.;Univ N Carolina, Dept Biostat, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27515 USA.;Univ N Carolina, Dept Comp Sci, Chapel Hill, NC 27515 USA. (författare)
  • Hou, LifangNorthwestern Univ Chicago, Feinberg Sch Med, Dept Prevent Med, Evanston, IL USA.;Northwestern Univ Chicago, Ctr Populat Epigenet, Robert H Lurie Comprehens Canc Ctr, Feinberg Sch Med, Evanston, IL USA. (författare)
  • Vokonas, Pantel S.Boston Univ, Sch Med, VA Normat Aging Study, VA Boston Healthcare Syst, Boston, MA 02118 USA.;Boston Univ, Sch Publ Hlth, VA Normat Aging Study, VA Boston Healthcare Syst, Boston, MA 02118 USA. (författare)
  • Ward-Caviness, Cavin K.Natl Hlth & Environm Effects Res Lab, Environm Publ Hlth Div, 104 Mason Farm Rd, Chapel Hill, NC 27514 USA. (författare)
  • Wilson, RoryGerman Res Ctr Environm Hlth, Res Unit Mol Epidemiol, Helmholtz Zentrum Munchen, D-85764 Neuherberg, Germany.;German Res Ctr Environm Hlth, Inst Epidemiol, Helmholtz Zentrum Munchen, D-85764 Neuherberg, Germany. (författare)
  • Wolf, KathrinGerman Res Ctr Environm Hlth, Inst Epidemiol, Helmholtz Zentrum Munchen, D-85764 Neuherberg, Germany. (författare)
  • Waldenberger, MelanieGerman Res Ctr Environm Hlth, Res Unit Mol Epidemiol, Helmholtz Zentrum Munchen, D-85764 Neuherberg, Germany.;German Res Ctr Environm Hlth, Inst Epidemiol, Helmholtz Zentrum Munchen, D-85764 Neuherberg, Germany. (författare)
  • Cyrys, JosefGerman Res Ctr Environm Hlth, Inst Epidemiol, Helmholtz Zentrum Munchen, D-85764 Neuherberg, Germany. (författare)
  • Peters, AnnetteGerman Res Ctr Environm Hlth, Inst Epidemiol, Helmholtz Zentrum Munchen, D-85764 Neuherberg, Germany.;Ludwig Maximilians Univ Munchen, Med Fac, Inst Med Informat Proc Biometry & Epidemiol, Munich, Germany. (författare)
  • Boezen, H. MarikeUniv Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands.;Univ Groningen, Univ Med Ctr Groningen, GRIAC Res Inst, Groningen, Netherlands. (författare)
  • Vonk, Judith M.Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands.;Univ Groningen, Univ Med Ctr Groningen, GRIAC Res Inst, Groningen, Netherlands. (författare)
  • Sayols-Baixeras, SergiUppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Univ Pompeu Fabra, Hosp Mar, Cardiovasc Epidemiol & Genet Res Grp, Med Res Inst IMIM, Campus Mar, Barcelona, Spain.;Inst Salud Carlos III, MP Enfermedades Cardiovasc CIBERCV, Consorcio CIBER, Madrid, Spain.(Swepub:uu)sersa467 (författare)
  • Lee, MikyeongNIEHS, Epidemiol Branch, NIH, US Dept HHS, POB 12233, Res Triangle Pk, NC 27709 USA. (författare)
  • Baccarelli, Andrea A.Columbia Univ, Dept Environm Hlth Sci, Lab Environm Epigenet, Mailman Sch Publ Hlth, New York, NY USA.;Columbia Univ, Dept Epidemiol, Lab Environm Epigenet, Mailman Sch Publ Hlth, New York, NY USA. (författare)
  • Whitsel, Eric A.Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27515 USA.;Univ N Carolina, Sch Med, Dept Med, Chapel Hill, NC 27515 USA. (författare)
  • Duke Univ, Sch Med, Dept Family Med & Community Hlth, Durham, NC USA.;Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27515 USA.Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27515 USA. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Environmental Research: Elsevier2120013-93511096-0953

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