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  • Zhang, YuanyuanWuhan Univ Sci & Technol, Sch Publ Hlth, 2 Huangjiahu West Rd,Qingling St, Wuhan 430065, Peoples R China (författare)

Early-life exposure to PM2.5 constituents and childhood asthma and wheezing : Findings from China, Children, Homes, Health study

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • Elsevier,2022
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-482407
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-482407URI
  • https://doi.org/10.1016/j.envint.2022.107297DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background: Emerging evidence suggests that early-life (in-utero and first-year since birth) exposure to ambient PM2.5 is a risk factor for asthma onset and exacerbation among children, while the hazards caused by PM2.5 compositions remain largely unknown.Objective: To examine potential associations of early-life exposures to PM2.5 mass and its major chemical constituents with childhood asthma and wheezing.Methods: By conducting the Phase II of the China, Children, Homes, Health study, we investigated 30,325 preschool children aged 3-6 years during 2019-2020 in mainland China. Early-life exposure to PM2.5 mass and its constituents (i.e., black carbon [BC], organic matter [OM], nitrate, ammonium, sulfate) were calculated based on monthly estimates at a 1 km x 1 km resolution from satellite-based models. We adopted a novel quantile-based g-computation approach to assess the effect of a mixture of PM2.5 constituents on childhood asthma/wheezing.Results: The average PM2.5 concentrations during in-utero and the first year since birth were 64.7 +/- 10.6 and 61.8 +/- 10.5 mu g/m(3), respectively. Early-life exposures to a mixture of major PM2 center dot 5 constituents were significantly associated with increased risks of asthma and wheezing, while no evident compositions-wheezing associations were found in the first year. Each quintile increases in all five PM2.5 components exposures in utero was accordingly associated with an odds ratio of 1.18 [95% confidence interval: 1.07-1.29] for asthma and 1.08 [1.01-1.16] for wheezing. BC, OM and SO42- contributed more to risks of asthma and wheezing than the other PM2.5 constituents during early life, wherein the effects of BC were only observed during pregnancy. Sex subgroup analyses suggested stronger associations among girls of first-year exposures to PM2.5 components with childhood asthma.Conclusion: Early-life exposures to ambient PM2.5, particularly compositions of BC, OM and SO42-, are associated with an increased risk of childhood asthma.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Yin, ZhouxinWuhan Univ Sci & Technol, Sch Publ Hlth, 2 Huangjiahu West Rd,Qingling St, Wuhan 430065, Peoples R China (författare)
  • Zhou, PeixuanWuhan Univ Sci & Technol, Sch Publ Hlth, 2 Huangjiahu West Rd,Qingling St, Wuhan 430065, Peoples R China (författare)
  • Zhang, LianshengWuhan Univ Sci & Technol, Sch Publ Hlth, 2 Huangjiahu West Rd,Qingling St, Wuhan 430065, Peoples R China (författare)
  • Zhao, ZhuohuiFudan Univ, Sch Publ Hlth, Shanghai, Peoples R China (författare)
  • Norbäck, DanUppsala universitet,Arbets- och miljömedicin(Swepub:uu)dagnorba (författare)
  • Zhang, XinShanxi Univ, Res Ctr Environm Sci & Engn, Taiyuan, Peoples R China (författare)
  • Lu, ChanCent South Univ, Xiangya Sch Publ Hlth, Changsha, Peoples R China (författare)
  • Yu, WeiChongqing Univ, Sch Civil Engn, Chongqing, Peoples R China (författare)
  • Wang, TingtingShanghai Univ Med & Hlth Sci, Shanghai, Peoples R China (författare)
  • Zheng, XiaohongSoutheast Univ, Sch Energy & Environm, Nanjing, Peoples R China (författare)
  • Zhang, LingWuhan Univ Sci & Technol, Sch Publ Hlth, 2 Huangjiahu West Rd,Qingling St, Wuhan 430065, Peoples R China.;Wuhan Univ Sci & Technol, Hubei Prov Key Lab Occupat Hazard Identificat & C, Wuhan 430065, Peoples R China (författare)
  • Zhang, YunquanWuhan Univ Sci & Technol, Sch Publ Hlth, 2 Huangjiahu West Rd,Qingling St, Wuhan 430065, Peoples R China.;Wuhan Univ Sci & Technol, Hubei Prov Key Lab Occupat Hazard Identificat & C, Wuhan 430065, Peoples R China (författare)
  • Wuhan Univ Sci & Technol, Sch Publ Hlth, 2 Huangjiahu West Rd,Qingling St, Wuhan 430065, Peoples R ChinaFudan Univ, Sch Publ Hlth, Shanghai, Peoples R China (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Environment International: Elsevier1650160-41201873-6750

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